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ATI Immune System Disorders Practice Exam
Preparation With Complete Questions And Correct
Answers With Rationales Already Graded A+ Brand
New Version!!
1. A nurse is caring for a client who has systemic lupus erythematosus
(SLE). Which laboratory finding should the nurse recognize as most
indicative of active disease progression?
A. Increased serum calcium level
B. Decreased erythrocyte sedimentation rate (ESR)
C. Elevated anti-double-stranded DNA antibodies
D. Increased platelet production
Answer: C. Elevated anti-double-stranded DNA antibodies
Explanation: Anti-double-stranded DNA antibodies are strongly
associated with SLE activity and can indicate increased autoimmune
activity, particularly when renal involvement is suspected. Elevated
levels often correlate with disease flare-ups. ESR may also increase
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during inflammation, but anti-dsDNA antibodies are more specific for
SLE.
2. A nurse is teaching a client who has human immunodeficiency virus
(HIV). Which statement by the client indicates an understanding of
antiretroviral therapy (ART)?
A. "I can stop taking medications when my viral load decreases."
B. "The medications will eliminate HIV from my body."
C. "I need to take my medications consistently to prevent resistance."
D. "The medications will increase my CD4 count immediately."
Answer: C. "I need to take my medications consistently to prevent
resistance."
Explanation: Strict adherence to ART prevents viral replication and
decreases the risk of developing drug-resistant HIV strains. ART does not
eradicate HIV but suppresses viral load and allows immune recovery.
3. A nurse is teaching about innate immunity. Which component is part
of this system?
A. T lymphocytes
B. Antibodies
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C. Skin and mucous membranes
D. Memory B cells
Answer: C. Skin and mucous membranes
Explanation: Innate immunity includes physical barriers like skin,
mucous membranes, and phagocytic cells. Adaptive immunity involves T
cells, B cells, and antibodies.
4. Which cell is primarily responsible for antibody production?
A. Cytotoxic T cell
B. Plasma B cell
C. Natural killer cell
D. Macrophage
Answer: B. Plasma B cell
Explanation: Plasma B cells differentiate from B lymphocytes and
secrete antibodies. Cytotoxic T cells kill infected cells. Natural killer cells
are part of innate immunity. Macrophages are phagocytic antigen-
presenting cells.
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5. A patient has a disorder affecting the thymus. Which immune cell
maturation would be most impaired?
A. B lymphocytes
B. T lymphocytes
C. Neutrophils
D. Eosinophils
Answer: B. T lymphocytes
Explanation: The thymus is the primary site for T-cell maturation. B cells
mature in bone marrow. Neutrophils and eosinophils are granulocytes
that mature in bone marrow.
6. Which immunoglobulin is the first to appear after initial antigen
exposure?
A. IgG
B. IgA
C. IgM
D. IgE
Answer: C. IgM
ATI Immune System Disorders Practice Exam
Preparation With Complete Questions And Correct
Answers With Rationales Already Graded A+ Brand
New Version!!
1. A nurse is caring for a client who has systemic lupus erythematosus
(SLE). Which laboratory finding should the nurse recognize as most
indicative of active disease progression?
A. Increased serum calcium level
B. Decreased erythrocyte sedimentation rate (ESR)
C. Elevated anti-double-stranded DNA antibodies
D. Increased platelet production
Answer: C. Elevated anti-double-stranded DNA antibodies
Explanation: Anti-double-stranded DNA antibodies are strongly
associated with SLE activity and can indicate increased autoimmune
activity, particularly when renal involvement is suspected. Elevated
levels often correlate with disease flare-ups. ESR may also increase
,2|Page
during inflammation, but anti-dsDNA antibodies are more specific for
SLE.
2. A nurse is teaching a client who has human immunodeficiency virus
(HIV). Which statement by the client indicates an understanding of
antiretroviral therapy (ART)?
A. "I can stop taking medications when my viral load decreases."
B. "The medications will eliminate HIV from my body."
C. "I need to take my medications consistently to prevent resistance."
D. "The medications will increase my CD4 count immediately."
Answer: C. "I need to take my medications consistently to prevent
resistance."
Explanation: Strict adherence to ART prevents viral replication and
decreases the risk of developing drug-resistant HIV strains. ART does not
eradicate HIV but suppresses viral load and allows immune recovery.
3. A nurse is teaching about innate immunity. Which component is part
of this system?
A. T lymphocytes
B. Antibodies
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C. Skin and mucous membranes
D. Memory B cells
Answer: C. Skin and mucous membranes
Explanation: Innate immunity includes physical barriers like skin,
mucous membranes, and phagocytic cells. Adaptive immunity involves T
cells, B cells, and antibodies.
4. Which cell is primarily responsible for antibody production?
A. Cytotoxic T cell
B. Plasma B cell
C. Natural killer cell
D. Macrophage
Answer: B. Plasma B cell
Explanation: Plasma B cells differentiate from B lymphocytes and
secrete antibodies. Cytotoxic T cells kill infected cells. Natural killer cells
are part of innate immunity. Macrophages are phagocytic antigen-
presenting cells.
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5. A patient has a disorder affecting the thymus. Which immune cell
maturation would be most impaired?
A. B lymphocytes
B. T lymphocytes
C. Neutrophils
D. Eosinophils
Answer: B. T lymphocytes
Explanation: The thymus is the primary site for T-cell maturation. B cells
mature in bone marrow. Neutrophils and eosinophils are granulocytes
that mature in bone marrow.
6. Which immunoglobulin is the first to appear after initial antigen
exposure?
A. IgG
B. IgA
C. IgM
D. IgE
Answer: C. IgM
