Adrenergic Receptors - B3
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Adipose
Lipolysis
Agents that increase BP increase
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cardiac work, which can lead to heart failure, cardiac arrest and stroke.
,Direct Acting Sympathomimetic Drugs (Alpha) - Phenylephrine
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α1 > α2
Cholinergic Effects in Blood Vessels
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There is no parasympathetic input to blood vessels, but cholinergic
receptors are present on endothelial cells that line the blood vessels. The
result is that direct agonists relax vascular smooth muscle.
Adrenergic Receptors - B2
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Smooth muscle (most organs and blood vessels supplying skeletal muscle)
Liver
Skeletal muscle
Relaxation
Glycogenesis and glucogenesis
Glycogenesis and K+ uptake
Organ System Effects of Adrenergic Inhibition -Uterus
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block β2
contract smooth muscle
Synaptic transmission step 3
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Membrane depolarization activates voltage-dependent Ca2+ channels,
allowing Ca2+ entry into the presynaptic nerve terminal.
NM
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Skeletal muscle
Opens Na+ and K+ channels
Overall, the drug effect is still greater than the compensation and the net effect of
phenylephrine is an
Give this one a try later!
increase in BP
Give this one a try later!
Adipose
Lipolysis
Agents that increase BP increase
Give this one a try later!
cardiac work, which can lead to heart failure, cardiac arrest and stroke.
,Direct Acting Sympathomimetic Drugs (Alpha) - Phenylephrine
Give this one a try later!
α1 > α2
Cholinergic Effects in Blood Vessels
Give this one a try later!
There is no parasympathetic input to blood vessels, but cholinergic
receptors are present on endothelial cells that line the blood vessels. The
result is that direct agonists relax vascular smooth muscle.
Adrenergic Receptors - B2
Give this one a try later!
Smooth muscle (most organs and blood vessels supplying skeletal muscle)
Liver
Skeletal muscle
Relaxation
Glycogenesis and glucogenesis
Glycogenesis and K+ uptake
Organ System Effects of Adrenergic Inhibition -Uterus
, Give this one a try later!
block β2
contract smooth muscle
Synaptic transmission step 3
Give this one a try later!
Membrane depolarization activates voltage-dependent Ca2+ channels,
allowing Ca2+ entry into the presynaptic nerve terminal.
NM
Give this one a try later!
Skeletal muscle
Opens Na+ and K+ channels
Overall, the drug effect is still greater than the compensation and the net effect of
phenylephrine is an
Give this one a try later!
increase in BP
