clearance of drug
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=rate of drug elimination/a drug concentration
=volume distribution x elimination constant
- gives indication of efficacy of elimination of drug from plasma
(volume/time are the units)
Indirect Acting Sympathomimetic Drugs: amphetamine
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stimulates release of NE from SNS neurons & in CNS (@ higher doses,
dopamine and serotonin also affected)
,IACAgonist: echothiophate
- type
- duration of action
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- organophosphate
- long action, irreversible
half-life
-what is it independent of?
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amount of time required for drug concentration to decrease by 50%
- independent of drug concentration and dose
Distribution of drugs
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Absorption of drug needed to establish adequate plasma drug levels in
tissues, usually begins before abs is done
B1 adrenergic receptor (excitatory)
- location and action
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, - inc rate/force of contraction of heart
- increased renin secretion in juxtaglomerular cells
B3 adrenergic receptor (excitatory)
- location and action
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lipolysis in adipose tissue
Adrenergic Antagonists beta Blockers
- drug name and receptor activity
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- metaprolol, B1 >>> B2
- propranolol, B1 = B2
- butoxamine, B2 >>> B1
agonist
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a drug that when bound to receptor, favours the active conformation
- mimics ligand action
, first pass effect (only for oral route)
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drug orally administered carried by portal system to liver before entering
systemic circulation, liver enzymes may inactivate fraction of drug
what properties allow drug to bind to receptor?
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enantiomers, charge, drugs bound through weak bonds
Loading dose
- equation to find it
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use of a higher dose than what is usually used for treatment to allow the
drug to reach the desired concentration sooner
- dose(loading) = Vd x Css
enterohepatic recycling
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the process whereby drug is eliminated from the liver/biliary tract into the
GI tract and then reabsorbed from the GI tract back to the liver via portal
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=rate of drug elimination/a drug concentration
=volume distribution x elimination constant
- gives indication of efficacy of elimination of drug from plasma
(volume/time are the units)
Indirect Acting Sympathomimetic Drugs: amphetamine
Give this one a try later!
stimulates release of NE from SNS neurons & in CNS (@ higher doses,
dopamine and serotonin also affected)
,IACAgonist: echothiophate
- type
- duration of action
Give this one a try later!
- organophosphate
- long action, irreversible
half-life
-what is it independent of?
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amount of time required for drug concentration to decrease by 50%
- independent of drug concentration and dose
Distribution of drugs
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Absorption of drug needed to establish adequate plasma drug levels in
tissues, usually begins before abs is done
B1 adrenergic receptor (excitatory)
- location and action
Give this one a try later!
, - inc rate/force of contraction of heart
- increased renin secretion in juxtaglomerular cells
B3 adrenergic receptor (excitatory)
- location and action
Give this one a try later!
lipolysis in adipose tissue
Adrenergic Antagonists beta Blockers
- drug name and receptor activity
Give this one a try later!
- metaprolol, B1 >>> B2
- propranolol, B1 = B2
- butoxamine, B2 >>> B1
agonist
Give this one a try later!
a drug that when bound to receptor, favours the active conformation
- mimics ligand action
, first pass effect (only for oral route)
Give this one a try later!
drug orally administered carried by portal system to liver before entering
systemic circulation, liver enzymes may inactivate fraction of drug
what properties allow drug to bind to receptor?
Give this one a try later!
enantiomers, charge, drugs bound through weak bonds
Loading dose
- equation to find it
Give this one a try later!
use of a higher dose than what is usually used for treatment to allow the
drug to reach the desired concentration sooner
- dose(loading) = Vd x Css
enterohepatic recycling
Give this one a try later!
the process whereby drug is eliminated from the liver/biliary tract into the
GI tract and then reabsorbed from the GI tract back to the liver via portal
