What are some phase I reactions?
Give this one a try later!
oxidation, reduction, hydrolysis
What is the dose response curve (DRC)?
Give this one a try later!
A depiction of the observed drug effect as a function of its own
concentration
What are the disadvantages of IV route?
,Give this one a try later!
- high risk of adverse effects
- have to inject slowly due to cardiac toxicity risk
- requires more skill to administer
What are the advantages of IM route?
Give this one a try later!
- Good for moderate volumes
- Safer and easier than IV
What is the simplest drug route?
Give this one a try later!
Oral
What effects can anti-nicotinic drugs have?
Give this one a try later!
- relaxation of skeletal muscle
- relaxation of smooth muscle in GI + bladder
- vasodilation
,What are the symptoms of muscarinic excess? DUMBELS
Give this one a try later!
Diarrhea
Urination
Miosis (excessive pupil constriction)
Bronchoconstriction
Excitation
Lacrimation (secretion of tears)
Sweating & Salivation
Which drugs are muscarinic agonists?
Give this one a try later!
Acetylcholine, muscarine, pilocarpine, bethanechol
Where do SNS preganglionic neurons arise?
Give this one a try later!
thoracic and lumbar segments of the spinal cord
What is the most rapid type of drug receptor?
Give this one a try later!
, Ion channel
Which fluids do acidic drugs accumulate in?
Give this one a try later!
Basic fluids
What are the 4 types of Phase II reactions?
Give this one a try later!
1. Glucuronic acid conjugation
2. Sulfate conjugation
3. Acetylation
4. Glutathione conjugation
Which drugs go through biliary excretion?
Give this one a try later!
drugs that are NOT BOUND to plasma proteins and are metabolized by
hepatocytes of the liver
What is a toxin?
Give this one a try later!
oxidation, reduction, hydrolysis
What is the dose response curve (DRC)?
Give this one a try later!
A depiction of the observed drug effect as a function of its own
concentration
What are the disadvantages of IV route?
,Give this one a try later!
- high risk of adverse effects
- have to inject slowly due to cardiac toxicity risk
- requires more skill to administer
What are the advantages of IM route?
Give this one a try later!
- Good for moderate volumes
- Safer and easier than IV
What is the simplest drug route?
Give this one a try later!
Oral
What effects can anti-nicotinic drugs have?
Give this one a try later!
- relaxation of skeletal muscle
- relaxation of smooth muscle in GI + bladder
- vasodilation
,What are the symptoms of muscarinic excess? DUMBELS
Give this one a try later!
Diarrhea
Urination
Miosis (excessive pupil constriction)
Bronchoconstriction
Excitation
Lacrimation (secretion of tears)
Sweating & Salivation
Which drugs are muscarinic agonists?
Give this one a try later!
Acetylcholine, muscarine, pilocarpine, bethanechol
Where do SNS preganglionic neurons arise?
Give this one a try later!
thoracic and lumbar segments of the spinal cord
What is the most rapid type of drug receptor?
Give this one a try later!
, Ion channel
Which fluids do acidic drugs accumulate in?
Give this one a try later!
Basic fluids
What are the 4 types of Phase II reactions?
Give this one a try later!
1. Glucuronic acid conjugation
2. Sulfate conjugation
3. Acetylation
4. Glutathione conjugation
Which drugs go through biliary excretion?
Give this one a try later!
drugs that are NOT BOUND to plasma proteins and are metabolized by
hepatocytes of the liver
What is a toxin?
