What is cachexia?
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Weight loss and wasting
BCL-2 FAMILY sensors -> BAX-BAK -> Caspase Cascade =
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Apoptosis
Hallmarks of cancer
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1. self-sufficiency in growth signals
2. insensitivity to antigrowth signals
3. evasion of apoptosis
4. limitless replicative potential
5. sustained angiogenesis
6. tissue invasion and metastasis
Lymphatic spread
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Tumor cells travel through lymphatic vessels to nearby lymph nodes and
beyond
What are the three major DNA repair systems
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- Mismatch pair
- Nucleotide excision repair
- Recombination repair
How does cancer cause anemia?
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, Chronic blood loss or bone marrow involvement.
What causes cachexia?
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Anorexia, malabsorption, and tumor-derived factors.
Dysplasia
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cell changes indicative of malignancy but no invasion present yet; warning
sign; common in epithelial tissues
Benign tumor names
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tissue source + -oma
What organs are common sites of metastasis
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, - Liver
- Bone
- Brain
Hypertrophy
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increase in cell size
Neoplastic changes
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...dont respond to normal stimuli
Main routes of metastasis
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- Lymphatic
- Bloodstream
Anaplasia
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Weight loss and wasting
BCL-2 FAMILY sensors -> BAX-BAK -> Caspase Cascade =
Give this one a try later!
Apoptosis
Hallmarks of cancer
,Give this one a try later!
1. self-sufficiency in growth signals
2. insensitivity to antigrowth signals
3. evasion of apoptosis
4. limitless replicative potential
5. sustained angiogenesis
6. tissue invasion and metastasis
Lymphatic spread
Give this one a try later!
Tumor cells travel through lymphatic vessels to nearby lymph nodes and
beyond
What are the three major DNA repair systems
Give this one a try later!
- Mismatch pair
- Nucleotide excision repair
- Recombination repair
How does cancer cause anemia?
Give this one a try later!
, Chronic blood loss or bone marrow involvement.
What causes cachexia?
Give this one a try later!
Anorexia, malabsorption, and tumor-derived factors.
Dysplasia
Give this one a try later!
cell changes indicative of malignancy but no invasion present yet; warning
sign; common in epithelial tissues
Benign tumor names
Give this one a try later!
tissue source + -oma
What organs are common sites of metastasis
Give this one a try later!
, - Liver
- Bone
- Brain
Hypertrophy
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increase in cell size
Neoplastic changes
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...dont respond to normal stimuli
Main routes of metastasis
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- Lymphatic
- Bloodstream
Anaplasia
Give this one a try later!
