UAMS HEMATOLOGY LAB
PRACTICAL FINAL EXAM
QUESTIONS AND ANSWERS 2026
- 2027
What are LE cells?
Smooth homogenous inclusion in a neutrophil.
Typically found in SLE patients.
What are the reagents needed for LAP test? What does this test
differentiate?
Leukocyte alkaline phosphotase stain. Differentiates CML from a
leukemoid reaction.
What will you see peripherally and in bone marrow for the
following:
Polycythemia Vera
Peripherally you will see a left shift, and large, bizarre platelets. Bone
marrow is hypercellular; packed all cell lines
What will you see peripherally and in bone marrow for the
following:
Myelofibrosis
Peripherally there is a left shift and NRBCs. The bone marrow is
variable, increased fibrosis results in a dry tap.
What will you see peripherally and in bone marrow for the
following: Essential Thrombocythemia
,Peripherally there is a left shift; giant, bizarre platelets and
micromegakaryocytes. The bone marrow is hypercellular; packed
platelets.
What will you see peripherally for the following: Bacterial
Infection
Dohle bodies, toxic granulation, vacuolization
What inclusion is always indicative of AML?
Auer Rods
What are the classifications of ALL and what morphologies do we
see with each?
L1-L3.
L1- small, uniform lymphoblasts
L2- large pleomorphic lymphoblasts
L3: vacuolated cells with abundant, deeply basophilic cytoplasm
Which type of ALL is most common? Who does this normally
affect?
L1, children
Best prognosis
Which type of ALL has the worst prognosis?
L3, Burkitt's
What cytochemial stain do we use to differentiate ALL?
PAS
What is the most common leukemia in adults and what do the
cells look like? What artifact do we see and how do we treat the
sample to correct for the artifact?
, Chronic Lymphocytic Leukemia. Small, mature lymphocytes in blood
and bone marrow.
What do we expect to see in the bone marrow in lymphocytic
leukemias?
Bone marrow is hypercellular with lymphoblasts. M:E ratio is normal.
What leukemia is TRAP positive?
Hairy cell leukemia
When do we see Sezary Cells?
Hodgkin's lymphoma
What is the difference between leukemia and lymphoma?
Leukemia starts in the bone marrow and spreads through the blood
into the RES. Lymphomas begin in the lymph nodes.
What type of lymphocyte is most commonly seen? T or B?
T lymphocyte. 51-88%
What is the most common plasma cell disorder?
Multiple myeloma
What other conditions are associated with multiple myeloma?
hyperviscosity syndrome, proteinuria (Bence Jones) or amyloidosis
What chemistry test do we use to diagnose multiple myeloma?
What about sed rate and rouleaux?
Calcium, protein electrophoresis (m spike). Rouleaux is a common
finding, increased ESR.
What is the difference between flame cell or a mott cell?
Flame cells have a pink cytoplasmic rim. Mott cells have russell
bodies in the cytoplasm.
PRACTICAL FINAL EXAM
QUESTIONS AND ANSWERS 2026
- 2027
What are LE cells?
Smooth homogenous inclusion in a neutrophil.
Typically found in SLE patients.
What are the reagents needed for LAP test? What does this test
differentiate?
Leukocyte alkaline phosphotase stain. Differentiates CML from a
leukemoid reaction.
What will you see peripherally and in bone marrow for the
following:
Polycythemia Vera
Peripherally you will see a left shift, and large, bizarre platelets. Bone
marrow is hypercellular; packed all cell lines
What will you see peripherally and in bone marrow for the
following:
Myelofibrosis
Peripherally there is a left shift and NRBCs. The bone marrow is
variable, increased fibrosis results in a dry tap.
What will you see peripherally and in bone marrow for the
following: Essential Thrombocythemia
,Peripherally there is a left shift; giant, bizarre platelets and
micromegakaryocytes. The bone marrow is hypercellular; packed
platelets.
What will you see peripherally for the following: Bacterial
Infection
Dohle bodies, toxic granulation, vacuolization
What inclusion is always indicative of AML?
Auer Rods
What are the classifications of ALL and what morphologies do we
see with each?
L1-L3.
L1- small, uniform lymphoblasts
L2- large pleomorphic lymphoblasts
L3: vacuolated cells with abundant, deeply basophilic cytoplasm
Which type of ALL is most common? Who does this normally
affect?
L1, children
Best prognosis
Which type of ALL has the worst prognosis?
L3, Burkitt's
What cytochemial stain do we use to differentiate ALL?
PAS
What is the most common leukemia in adults and what do the
cells look like? What artifact do we see and how do we treat the
sample to correct for the artifact?
, Chronic Lymphocytic Leukemia. Small, mature lymphocytes in blood
and bone marrow.
What do we expect to see in the bone marrow in lymphocytic
leukemias?
Bone marrow is hypercellular with lymphoblasts. M:E ratio is normal.
What leukemia is TRAP positive?
Hairy cell leukemia
When do we see Sezary Cells?
Hodgkin's lymphoma
What is the difference between leukemia and lymphoma?
Leukemia starts in the bone marrow and spreads through the blood
into the RES. Lymphomas begin in the lymph nodes.
What type of lymphocyte is most commonly seen? T or B?
T lymphocyte. 51-88%
What is the most common plasma cell disorder?
Multiple myeloma
What other conditions are associated with multiple myeloma?
hyperviscosity syndrome, proteinuria (Bence Jones) or amyloidosis
What chemistry test do we use to diagnose multiple myeloma?
What about sed rate and rouleaux?
Calcium, protein electrophoresis (m spike). Rouleaux is a common
finding, increased ESR.
What is the difference between flame cell or a mott cell?
Flame cells have a pink cytoplasmic rim. Mott cells have russell
bodies in the cytoplasm.
