ONS CHEMO/BIO Exam with all Correct & 100% Verified
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1. Aklylating Agents -Cyclophosphamide
-Cisplatin
-Carboplatin
-Oxaliplatin
2. Cyclophosphamide Alkylating agent (cytotoxic antineoplastic)
(Cytox-an)
Kills rapidly growing cells by interrupting DNA/RNA
synthesis Can cause bone marrow suppression, *N/V,
*acute hemorrhagic cystitis*, alopecia
*Aggressive hydration pre and post infusion*
3. Cisplatin Vesicant
Severe n/v
Renal failure (hydration and electrolyte replacement)
Ototoxicity, peripheral neuropathy
4. Carboplatin Irritant
Calculated dose with AUC
Anaphylactic events have been
noted Alopecia
Myelosuppression
5. Oxaliplatin Treat like vesicant
Part of FOLFOX (5FU, Leucovorin, Oxali) for colorectal
Pregnancy risk factor D
--> Pulmonary fibrosis, hepatotoxicity, sensoral
peripheral neu-ropathy (acute and long acting)
6. Antimetabolites Interfere at cell cycle in 'S'
PHASE 5-fluorouracil
Azacitidine
Capecitabine
, ONS CHEMO/BIO Exam with all Correct & 100% Verified
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Cytarabine
Fludarabine
Hydroxyurea
Leucovorin
Methotrexate
7. Methotrexate Not irritant or
vesicant IV, IM, IT,
IA
Can be used to treat RA
Acute: arachnoiditis (after IT), pneumonitis
Serious: renal failure/azotemia (increase BUN/CR,
decrease UO) Other: use with Leucovorin and
hydration to protect kidneys
8. 5FU Not a vesicant or irritant
Contraindicated: poor nutritional status, depressed bone
marrow function, infection
Acute: severe diarrhea, mucositis,
Serious: CARDIAC ie MI, arrhythmias, angina, hypotension
*Given with leucovorin... increases risk for diarrhea and
mucositis
9. Antitumor Antibiotics Bleomycin
Dactinomycin
Mitomycin
Mitoxantrone
10. Anthracyclines
Daunorubici
n
Doxorubic
, ONS CHEMO/BIO Exam with all Correct & 100% Verified
Answers |Latest Update |Already Graded A+
in
Epirubicin
Idarubicin
11. Doxorubicin VESICANT
IV push, short infuse, continuous infuse
Maximum cumulative dose: 450-
550mg/m2
, ONS CHEMO/BIO Exam with all Correct & 100% Verified
Answers |Latest Update |Already Graded A+
Maximum cumlative dose with cyclophos or XRT is
450mg/m2 Contraindicated for EF <45%
CARDIOTOXIC
Serious: local tissue (extravasation)
SE: alopecia, n/v/d, esophagitis, stomatitis, anorexia,
myelosupres-sion
*urine will be red/orange tinged
12. Nitrosoureas *able to cross blood brain
barrier* Carmustine
Lomustine
Streptozocin
13. Carmustine Irritant
Cumulative max dose of 1400mg/m2
Pulmonary toxicity (PFT's throughout entire course of
treatment) Renal toxicity with prolonged therapy
Other: hypotension, alopecia, facial flush
14. Camptothecins
Irinoteca
n
Topoteca
n
15. Irinotecan Irritant
DIARRHEA-- use of atropine, IV hydration, anti-
diarrheals Severe anaphylactic reactions noted
Other: vasodilation, alopecia, stomatitis,
16. Plant Alkaloids Epipodophyllotoxins work in the S and G2 phases to inhibit
DNA
synthesis. The taxanes stabilize microtubules in the G2
Answers |Latest Update |Already Graded A+
1. Aklylating Agents -Cyclophosphamide
-Cisplatin
-Carboplatin
-Oxaliplatin
2. Cyclophosphamide Alkylating agent (cytotoxic antineoplastic)
(Cytox-an)
Kills rapidly growing cells by interrupting DNA/RNA
synthesis Can cause bone marrow suppression, *N/V,
*acute hemorrhagic cystitis*, alopecia
*Aggressive hydration pre and post infusion*
3. Cisplatin Vesicant
Severe n/v
Renal failure (hydration and electrolyte replacement)
Ototoxicity, peripheral neuropathy
4. Carboplatin Irritant
Calculated dose with AUC
Anaphylactic events have been
noted Alopecia
Myelosuppression
5. Oxaliplatin Treat like vesicant
Part of FOLFOX (5FU, Leucovorin, Oxali) for colorectal
Pregnancy risk factor D
--> Pulmonary fibrosis, hepatotoxicity, sensoral
peripheral neu-ropathy (acute and long acting)
6. Antimetabolites Interfere at cell cycle in 'S'
PHASE 5-fluorouracil
Azacitidine
Capecitabine
, ONS CHEMO/BIO Exam with all Correct & 100% Verified
Answers |Latest Update |Already Graded A+
Cytarabine
Fludarabine
Hydroxyurea
Leucovorin
Methotrexate
7. Methotrexate Not irritant or
vesicant IV, IM, IT,
IA
Can be used to treat RA
Acute: arachnoiditis (after IT), pneumonitis
Serious: renal failure/azotemia (increase BUN/CR,
decrease UO) Other: use with Leucovorin and
hydration to protect kidneys
8. 5FU Not a vesicant or irritant
Contraindicated: poor nutritional status, depressed bone
marrow function, infection
Acute: severe diarrhea, mucositis,
Serious: CARDIAC ie MI, arrhythmias, angina, hypotension
*Given with leucovorin... increases risk for diarrhea and
mucositis
9. Antitumor Antibiotics Bleomycin
Dactinomycin
Mitomycin
Mitoxantrone
10. Anthracyclines
Daunorubici
n
Doxorubic
, ONS CHEMO/BIO Exam with all Correct & 100% Verified
Answers |Latest Update |Already Graded A+
in
Epirubicin
Idarubicin
11. Doxorubicin VESICANT
IV push, short infuse, continuous infuse
Maximum cumulative dose: 450-
550mg/m2
, ONS CHEMO/BIO Exam with all Correct & 100% Verified
Answers |Latest Update |Already Graded A+
Maximum cumlative dose with cyclophos or XRT is
450mg/m2 Contraindicated for EF <45%
CARDIOTOXIC
Serious: local tissue (extravasation)
SE: alopecia, n/v/d, esophagitis, stomatitis, anorexia,
myelosupres-sion
*urine will be red/orange tinged
12. Nitrosoureas *able to cross blood brain
barrier* Carmustine
Lomustine
Streptozocin
13. Carmustine Irritant
Cumulative max dose of 1400mg/m2
Pulmonary toxicity (PFT's throughout entire course of
treatment) Renal toxicity with prolonged therapy
Other: hypotension, alopecia, facial flush
14. Camptothecins
Irinoteca
n
Topoteca
n
15. Irinotecan Irritant
DIARRHEA-- use of atropine, IV hydration, anti-
diarrheals Severe anaphylactic reactions noted
Other: vasodilation, alopecia, stomatitis,
16. Plant Alkaloids Epipodophyllotoxins work in the S and G2 phases to inhibit
DNA
synthesis. The taxanes stabilize microtubules in the G2
