Neonatal Hematologic System Exam Questions
with 100% Correct Answers
direct coombs
detects antibodies stuck to the surface of a red blood cell
positive test - antibodies are attacking the RBC
direct coombs is positive in setting of
hemolytic anemia
chronic lymphocytic leukemia
infectious mononucleosis
mycoplasma infection
syphilis
systemic lupus
transfusion reaction
indirect coombs
done on maternal blood prenatally
detects the presence of unbound antibodies in the bloodstream
positive test - antibodies present that could attack against certain RBCs and cause hemolytic
anemia for the newborn
coagulation disorders
can either cause excessive or inadequate clotting
deficiency in greater than or equal 1 clotting factor
what are the coagulation disorders
, hemophilia A
hemophilia B
hemophilia C
von Willebrand disease
vitamin k deficiency
platelets
quantitative measure of circulating platelet volume in blood - essential for blood clotting
low levels of platelets indicate
excessive consumption or destruction, production, or storage problems
can lead to excessive bleeding
high levels of platelets indicate
reaction to disease states like cancer or infection
can lead to clotting abnormalities
PT/INR
assessment of extrinsic clotting pathway - integrating the activation of factor X by factor VII
and tissue factor
factor Xa w/ factor Va as cofactor active prothrombin (factor II) to form thrombin
thrombin cleaves fibrinogen to fibrin (the clot)
PTT
assessment of intrinsic clotting pathway and the activation of factor X by factors XII, XI, IX,
and VIII as well as downstream factors of common coagulation pathway (factor V,
prothrombin, fibrinogen)
with 100% Correct Answers
direct coombs
detects antibodies stuck to the surface of a red blood cell
positive test - antibodies are attacking the RBC
direct coombs is positive in setting of
hemolytic anemia
chronic lymphocytic leukemia
infectious mononucleosis
mycoplasma infection
syphilis
systemic lupus
transfusion reaction
indirect coombs
done on maternal blood prenatally
detects the presence of unbound antibodies in the bloodstream
positive test - antibodies present that could attack against certain RBCs and cause hemolytic
anemia for the newborn
coagulation disorders
can either cause excessive or inadequate clotting
deficiency in greater than or equal 1 clotting factor
what are the coagulation disorders
, hemophilia A
hemophilia B
hemophilia C
von Willebrand disease
vitamin k deficiency
platelets
quantitative measure of circulating platelet volume in blood - essential for blood clotting
low levels of platelets indicate
excessive consumption or destruction, production, or storage problems
can lead to excessive bleeding
high levels of platelets indicate
reaction to disease states like cancer or infection
can lead to clotting abnormalities
PT/INR
assessment of extrinsic clotting pathway - integrating the activation of factor X by factor VII
and tissue factor
factor Xa w/ factor Va as cofactor active prothrombin (factor II) to form thrombin
thrombin cleaves fibrinogen to fibrin (the clot)
PTT
assessment of intrinsic clotting pathway and the activation of factor X by factors XII, XI, IX,
and VIII as well as downstream factors of common coagulation pathway (factor V,
prothrombin, fibrinogen)
