MIMG 185 Final Task Questions and Correct
Answers
B7
In the absence of co-stimulation no T cell maturation and CD40L expression (only IgM)
IL-4
Necessary to turn on transcription from it Ie region, the first step in isotype switching to IgE
AID
Necessary for isotype switching ; it participates in cutting the DNA
RAG
Required for VJ and VDJ assembly, a step required to make functional variable regions.
C3
Central player in the complement cascade. Necessary for a robust immune response, it is not
required for Ab production.
^5
Part of the pre-B cell receptor and its expression is required for B cell development.
CD28
Absence of co-stimulation (signal 2) do not get T Cell maturation and will not have the
expression of CD40L required for isotype switching
IgB
Part of the BCR and in its absence B cell development is impaired
Answers
B7
In the absence of co-stimulation no T cell maturation and CD40L expression (only IgM)
IL-4
Necessary to turn on transcription from it Ie region, the first step in isotype switching to IgE
AID
Necessary for isotype switching ; it participates in cutting the DNA
RAG
Required for VJ and VDJ assembly, a step required to make functional variable regions.
C3
Central player in the complement cascade. Necessary for a robust immune response, it is not
required for Ab production.
^5
Part of the pre-B cell receptor and its expression is required for B cell development.
CD28
Absence of co-stimulation (signal 2) do not get T Cell maturation and will not have the
expression of CD40L required for isotype switching
IgB
Part of the BCR and in its absence B cell development is impaired
