Answers
Question: estrogen functions
Correct Answer: sexual maturity: development and maintenance of female secondary sex characteristics
Question: estrogen functions
Correct Answer: reproductive cycle: - follicular (ending with ovulation at day 14) and luteal phases
(ending with menstruation) - proliferation of uterine endothelium and endocervical mucus production
Question: estrogen functions
Correct Answer: bones: maintenance of bone health by blocking the actions of osteoclasts
Question: estrogen functions
Correct Answer: cholesterol: favors beneficial ratio of HDL:LDL (considered cardioprotective)
Question: estrogen functions
Correct Answer: coagulation: complex, but clinically considered thrombogenic
Question: progesterone functions
Correct Answer: reproductive cycle - luteal phase - secretory phase and hypertrophy of the endometrium
in preparation for implantation of the zygote
Question: progesterone - no implantation
Correct Answer: corpus luteum breaks down, progesterone declines, and endometrium sheds
(menstruation)
Question: progesterone - implantation
Correct Answer: corpus luteum and placenta synthesize and release progesterone to support the
endometrial lining and the pregnancy
Question: uses of estrogen and progesterone
Correct Answer: contraception - menopausal hormone therapy - gender affirmation and transgender health
- acne - female hypogonadism
Question: estrogen treating acne
Correct Answer: antibiotics used to treat organism and estrogen and/or anti-androgens are used to block
the influence of testosterone
Question: estrogen treating hypogonadism
Correct Answer: in absence of estrogen therapy, secondary sex characteristics will not develop - estrogen
administered exogenously
Question: composition of combination pills for contraception
Correct Answer: estradiol AND 1 of 4 generations of progestins to prevent ovulation
Question: combination pills MOA
, Correct Answer: 28 day cycle (21 active medication and 7 placebo) - placebo pills initiate menstruation -
prevent ovulation
Question: 2 ways to eliminate menstruation
Correct Answer: 1) take an extended cycle oral contraception 2) take a monophastic oral contraceptive and
skip placebo pills
Question: example of extended cycle oral contraceptive
Correct Answer: LoSeasonique - 20 mcg ethinyl estradiol - 0.1 mg levonorgestrel $$$
Question: example of monophasic oral contraceptive
Correct Answer: Lutera - 20 mcg ethinyl estradiol - 0.1 mg levonorgestrel cheaper
Question: initiation criteria for combination pills
Correct Answer: if within 5 days of starting menstruation, no backup method needed - if greater than 5
days of starting menstruation, 7 days of abstinence/backup method
Question: estrogen side effects
Correct Answer: nausea, breast tenderness, swelling
Question: progestin side effects
Correct Answer: appetite and weight gain, fatigue, depression
Question: absolute contraindications to combination pill use
Correct Answer: thrombolytic disorders - abnormal liver function - known or suspected breast cancer -
undiagnosed abnormal vaginal bleeding - known or suspected pregnancy - smokes over age 35
Question: progestin only pills MOA
Correct Answer: alter cervical mucosa making it hostile to sperm and making the endometrium less
susceptible to implantation *women still ovulate
Question: progestin only pills common side effects
Correct Answer: appetite and weight gain, fatigue, depression, spotting (one of the primary reasons
women stop using)
Question: other ways of taking estrogen and/or progestins
Correct Answer: combined hormones: transdermal patch (Ortho Evra, weekly) and vaginal ring (monthly)
- subdermal system: progestin releasing rod (Nexplannon, 3 years) - depot injections: medroxyprogesterone
(DepoProvera, 3 months) - IUDs
Question: 2 forms of emergency contraception
Correct Answer: medicines (usually progestins) - copper IUD
Question: ways to use medicines for emergency contraception
Correct Answer: PlanB (levonorgestrel 1.5 mg) - Lutera (20 mcg ethinyl estradiol and 0.1 mg
levonorgestrel) - take 5 pills at a time over 12 hours
Question: medical abortion drugs