Week 4 Exam: NR565 / NR 565
(Latest ) Advanced
Pharmacology Fundamentals |
Questions & Answers | 100%
Correct | Grade A - Chamberlain
Question:
Biological (Large molecule) DMARDs
Answer:
o Immunosuppressive drugs that target specific components of
inflammatory process. Manufactured using recombinant DNA technology
and are very expensive.
o Use when pt does not respond to conventional DMARDs
Can add on or substitute
,Question:
Cyclosporine (Neoral, Sandimmune)
Answer:
· Conventional DMARD, not recommended. Last resort drug.
· Used to prevent transplant rejection and can reduce symptoms of RA.
· Can cause kidney damage and other serious side effects.
· Reserved for progressive RA that has not responded to safer DMARDs.
· Can add to methotrexate and show significant improvement.
Question:
DMARD: Black Box Warning
Answer:
· Methotrexate can cause numerous and potentially fatal toxicities of the
bone marrow, liver (hepatic fibrosis), lungs (pneumonitis), and kidneys.
Other fatalities associated with skin reactions due to hemorrhagic enteritis
and gastrointestinal perforation. Congenital anomalies in pregnancy.
o Can supplement with folic acid 5mg/week to reduce risk
, Question:
T-Cell Activation Inhibitors (Abatacept)
Answer:
AKA Orencia
· T-cells inhabit synovium of patients with RA and play key role in
autoimmune attack on joints.
· Abatacept prevents activation of T-cell.
· Only drug class approved to treat RA
· Indications
o 1. Reduce RA symptoms and delay disease progression in moderate to
severe RA
o 2. Decrease symptoms of moderate to severe active polyarticular juvenile
idiopathic arthritis in children 6 years and older
o 3. Pt's who have not responded to methotrexate or TNF inhibitors.
· ADR:
o Headache, upper respiratory infections, nasopharyngitis and nausea
o Increases risk for infections: pneumonia, cellulitis, bronchitis,
diverticulitis, pyelonephritis, and UTI's
(Latest ) Advanced
Pharmacology Fundamentals |
Questions & Answers | 100%
Correct | Grade A - Chamberlain
Question:
Biological (Large molecule) DMARDs
Answer:
o Immunosuppressive drugs that target specific components of
inflammatory process. Manufactured using recombinant DNA technology
and are very expensive.
o Use when pt does not respond to conventional DMARDs
Can add on or substitute
,Question:
Cyclosporine (Neoral, Sandimmune)
Answer:
· Conventional DMARD, not recommended. Last resort drug.
· Used to prevent transplant rejection and can reduce symptoms of RA.
· Can cause kidney damage and other serious side effects.
· Reserved for progressive RA that has not responded to safer DMARDs.
· Can add to methotrexate and show significant improvement.
Question:
DMARD: Black Box Warning
Answer:
· Methotrexate can cause numerous and potentially fatal toxicities of the
bone marrow, liver (hepatic fibrosis), lungs (pneumonitis), and kidneys.
Other fatalities associated with skin reactions due to hemorrhagic enteritis
and gastrointestinal perforation. Congenital anomalies in pregnancy.
o Can supplement with folic acid 5mg/week to reduce risk
, Question:
T-Cell Activation Inhibitors (Abatacept)
Answer:
AKA Orencia
· T-cells inhabit synovium of patients with RA and play key role in
autoimmune attack on joints.
· Abatacept prevents activation of T-cell.
· Only drug class approved to treat RA
· Indications
o 1. Reduce RA symptoms and delay disease progression in moderate to
severe RA
o 2. Decrease symptoms of moderate to severe active polyarticular juvenile
idiopathic arthritis in children 6 years and older
o 3. Pt's who have not responded to methotrexate or TNF inhibitors.
· ADR:
o Headache, upper respiratory infections, nasopharyngitis and nausea
o Increases risk for infections: pneumonia, cellulitis, bronchitis,
diverticulitis, pyelonephritis, and UTI's
