D236 PATHOPHYSIOLOGY OA
OBJECTIVE ASSESSMENT EXAM
2026 ACTUAL QUESTIONS AND
ANSWERS WGU |SOLVED
Question 1: A patient presents with muscle weakness and bone pain after years of sedentary lifestyle
and poor nutrition. Which cellular process is most likely disrupted in their bones causing increased
fragility?
Enhanced osteoblast activity
Decreased osteoclast function
Excessive osteoclastic activity
Increased calcium absorption
Show Answer
Question 2: During an inflammatory response, which cell type is primarily responsible for releasing
histamine to increase vascular permeability and allow immune cells to reach the injury site
effectively?
Dendritic cells
Mast cells
Neutrophils
Lymphocytes
Show Answer
Question 3: A nurse notices that a diabetic patient's blood pH is dropping below normal range. Which
compensatory mechanism will the body activate first to restore acid base balance quickly?
Protein buffer system
, Renal acid excretion
Respiratory rate increase
Phosphate buffer activation
Show Answer
Question 4: A genetic counselor explains that a child inherited a disease requiring defective genes
from both parents. What inheritance pattern best describes this scenario where carriers show no
symptoms?
Autosomal dominant inheritance
Autosomal recessive inheritance
X-linked dominant inheritance
Mitochondrial inheritance pattern
Show Answer
Question 5: Following a bone fracture, which phase involves the formation of new blood vessels and
soft tissue that bridges the fracture gap before actual bone formation begins?
Hematoma formation phase
Granulation tissue formation
Callus formation phase
Remodeling phase completion
Show Answer
Question 6: During transcription, which enzyme is responsible for copying the DNA sequence into
messenger RNA within the cell nucleus before protein synthesis can occur at ribosomes?
DNA polymerase enzyme
RNA polymerase enzyme
Helicase enzyme complex
Ligase enzyme system
Show Answer
OBJECTIVE ASSESSMENT EXAM
2026 ACTUAL QUESTIONS AND
ANSWERS WGU |SOLVED
Question 1: A patient presents with muscle weakness and bone pain after years of sedentary lifestyle
and poor nutrition. Which cellular process is most likely disrupted in their bones causing increased
fragility?
Enhanced osteoblast activity
Decreased osteoclast function
Excessive osteoclastic activity
Increased calcium absorption
Show Answer
Question 2: During an inflammatory response, which cell type is primarily responsible for releasing
histamine to increase vascular permeability and allow immune cells to reach the injury site
effectively?
Dendritic cells
Mast cells
Neutrophils
Lymphocytes
Show Answer
Question 3: A nurse notices that a diabetic patient's blood pH is dropping below normal range. Which
compensatory mechanism will the body activate first to restore acid base balance quickly?
Protein buffer system
, Renal acid excretion
Respiratory rate increase
Phosphate buffer activation
Show Answer
Question 4: A genetic counselor explains that a child inherited a disease requiring defective genes
from both parents. What inheritance pattern best describes this scenario where carriers show no
symptoms?
Autosomal dominant inheritance
Autosomal recessive inheritance
X-linked dominant inheritance
Mitochondrial inheritance pattern
Show Answer
Question 5: Following a bone fracture, which phase involves the formation of new blood vessels and
soft tissue that bridges the fracture gap before actual bone formation begins?
Hematoma formation phase
Granulation tissue formation
Callus formation phase
Remodeling phase completion
Show Answer
Question 6: During transcription, which enzyme is responsible for copying the DNA sequence into
messenger RNA within the cell nucleus before protein synthesis can occur at ribosomes?
DNA polymerase enzyme
RNA polymerase enzyme
Helicase enzyme complex
Ligase enzyme system
Show Answer
