MCB 317 Exam 1 Practice Questions with
CORRECT Answers
As discussed in lecture, Punnett squares can be considered a visual representation of
Mendel's Law of Segregation.
True
As discussed in lecture, it is not possible for two people who have the O blood type to
produce an offspring with the A blood type (assuming that no new mutations arise in the
parents or offspring).
False - two O parents can have an A type child due to complementary gene action and epistasis -
one parent has IA allele masked by mutation in H gene.
In mitosis homologous chromosomes pair on the metaphase plate.
False - occurs in meiosis
As discussed in lecture, Molecular Genetics / Recombinant DNA Bridges Biochemistry &
Classical Genetics.
True
As described in lecture, one useful definition of a wild-type allele is any allele whose
frequency in the population is greater than 1%
TRUE
Mitosis process
,A single eukaryotic cell divides to produce two genetically identical daughter cells, ensuring
growth, repair, and asexual reproduction.
Separates sister chromatids
Interphase, prophase, prometaphase, metaphase, anaphase, telophase, and cytokinesis.
Meiosis process
Cell division that produces four genetically distinct haploid gametes from a single diploid cell,
reducing the chromosome number by half.
Meiosis I (homologous chromosomes separate) and Meiosis II (like mitosis - separates sister
chromatids)
Codominance
A condition in which neither of two alleles of a gene is dominant or recessive.
Displays phenotypes seen in both parents
Pleiotropy
When one gene governs more than one phenotype
Incomplete dominance
Situation in which one allele is not completely dominant over another allele
Often due to a dosage effect
As discussed in lecture, Mendel's observation that in a monohybrid cross in peas two
alternate alleles produced a 3:1 phenotypic ratio of F2's supported which of the following
conclusions?
,There are two copies of genetic information for the trait in somatic cells
Inheritance is particulate
Fraglie X syndrome
Often due to a polymorphism associated with a MICROsatellite
Microsatellites
Also called short tandem repeats (STRs); refers to sequences of repeated base pairs of DNA,
usually no more than two to six. If repeated excessively, they are often associated with
neurological disorders, such as Huntington's chorea.
In class we discussed work estimating the likelihood that women with BRCA1 or BRCA2
mutations would get breast or ovarian cancer. Which of the following genetic terms best
relates to "likelihood"?
Variable penetrance
Haplotype
A collection of SNPs within a region
Microsatellite
SSR - Simple Sequence Repeat or short tandem repeat.
Minisatellite
Detected in DNA fingerprinting
Consist of longer repeating sequences, usually 10-100 base pairs.
, In lecture we discussed the use of mass spectrometry in one method of genotyping.
What type of polymorphism did that method detect?
Polymorphisms associated with a SNP
SNP (single nucleotide polymorphism)
A polymorphism that substitutes one base pair for another
In a species of tropical fish, a colorful orange and black variety called motezuma occurs.
When two motezuma are crossed 2/3 of the resulting progeny are motezuma and 1/3 are
the wild-type, dark grayish green color. Montezuma is a single-gene trait, and Montezuma
fish are never true-breeding. What is the most likely pattern of inheritance/genetic
property associated with the Montezuma gene?
Recessive lethality
Recessive Lethality
An allele that causes death when homozygous recessive
In lecture we discussed the fact that many genomic techniques can be considered to be
"scaled-up" variations on standard genetic techniques. In lecture, we discussed the use of
microarrays to detects SNPs at many loci simultaneously. Those micro-arrays are
essentially a scaled-up variation on which standard genetic technique discussed in lecture?
ASO genotyping
ASO genotyping
CORRECT Answers
As discussed in lecture, Punnett squares can be considered a visual representation of
Mendel's Law of Segregation.
True
As discussed in lecture, it is not possible for two people who have the O blood type to
produce an offspring with the A blood type (assuming that no new mutations arise in the
parents or offspring).
False - two O parents can have an A type child due to complementary gene action and epistasis -
one parent has IA allele masked by mutation in H gene.
In mitosis homologous chromosomes pair on the metaphase plate.
False - occurs in meiosis
As discussed in lecture, Molecular Genetics / Recombinant DNA Bridges Biochemistry &
Classical Genetics.
True
As described in lecture, one useful definition of a wild-type allele is any allele whose
frequency in the population is greater than 1%
TRUE
Mitosis process
,A single eukaryotic cell divides to produce two genetically identical daughter cells, ensuring
growth, repair, and asexual reproduction.
Separates sister chromatids
Interphase, prophase, prometaphase, metaphase, anaphase, telophase, and cytokinesis.
Meiosis process
Cell division that produces four genetically distinct haploid gametes from a single diploid cell,
reducing the chromosome number by half.
Meiosis I (homologous chromosomes separate) and Meiosis II (like mitosis - separates sister
chromatids)
Codominance
A condition in which neither of two alleles of a gene is dominant or recessive.
Displays phenotypes seen in both parents
Pleiotropy
When one gene governs more than one phenotype
Incomplete dominance
Situation in which one allele is not completely dominant over another allele
Often due to a dosage effect
As discussed in lecture, Mendel's observation that in a monohybrid cross in peas two
alternate alleles produced a 3:1 phenotypic ratio of F2's supported which of the following
conclusions?
,There are two copies of genetic information for the trait in somatic cells
Inheritance is particulate
Fraglie X syndrome
Often due to a polymorphism associated with a MICROsatellite
Microsatellites
Also called short tandem repeats (STRs); refers to sequences of repeated base pairs of DNA,
usually no more than two to six. If repeated excessively, they are often associated with
neurological disorders, such as Huntington's chorea.
In class we discussed work estimating the likelihood that women with BRCA1 or BRCA2
mutations would get breast or ovarian cancer. Which of the following genetic terms best
relates to "likelihood"?
Variable penetrance
Haplotype
A collection of SNPs within a region
Microsatellite
SSR - Simple Sequence Repeat or short tandem repeat.
Minisatellite
Detected in DNA fingerprinting
Consist of longer repeating sequences, usually 10-100 base pairs.
, In lecture we discussed the use of mass spectrometry in one method of genotyping.
What type of polymorphism did that method detect?
Polymorphisms associated with a SNP
SNP (single nucleotide polymorphism)
A polymorphism that substitutes one base pair for another
In a species of tropical fish, a colorful orange and black variety called motezuma occurs.
When two motezuma are crossed 2/3 of the resulting progeny are motezuma and 1/3 are
the wild-type, dark grayish green color. Montezuma is a single-gene trait, and Montezuma
fish are never true-breeding. What is the most likely pattern of inheritance/genetic
property associated with the Montezuma gene?
Recessive lethality
Recessive Lethality
An allele that causes death when homozygous recessive
In lecture we discussed the fact that many genomic techniques can be considered to be
"scaled-up" variations on standard genetic techniques. In lecture, we discussed the use of
microarrays to detects SNPs at many loci simultaneously. Those micro-arrays are
essentially a scaled-up variation on which standard genetic technique discussed in lecture?
ASO genotyping
ASO genotyping
