NURS 5463 TEST 4 NEWEST 2026 ACTUAL EXAM|
COMPLETE QUESTIONS AND CORRECT DETAILED
ANSWERS (VERIFIED ANSWERS) ALREADY GRADED
A+|| NEW!!
1. A patient with a history of liver cirrhosis is prescribed a
medication that is highly metabolized by the liver. What
change in pharmacokinetics should the nurse anticipate?
A. Increased renal excretion
B. Decreased first-pass effect
C. Increased protein binding
D. Decreased half-life
Correct Answer: B
Rationale: Liver cirrhosis impairs hepatic function and blood
flow, leading to a significant reduction in first-pass metabolism.
This results in increased bioavailability of the drug. Protein
1
,binding is often decreased due to low albumin, and half-life is
typically prolonged.
2. The nurse is administering a drug that is a weak acid.
Which condition would promote the excretion of this drug in
the urine?
A. Alkalinization of the urine
B. Acidification of the urine
C. Decreased glomerular filtration rate
D. Increased active tubular reabsorption
Correct Answer: A
Rationale: "Ion trapping" dictates that weak acids are excreted
faster in alkaline urine. In an alkaline environment, the weak acid
dissociates into its ionized form, which is polar and less likely to
be reabsorbed in the renal tubules, thus promoting excretion.
3. A drug is administered intravenously and has a volume of
distribution (Vd) of 40 L. This indicates the drug:
2
,A. Is largely confined to the plasma
B. Is widely distributed into tissues
C. Is highly protein bound
D. Has a short duration of action
Correct Answer: B
Rationale: A standard Vd is about 4-5 L for plasma. A Vd of 40
L suggests the drug has left the plasma and is extensively
distributed into body tissues and fluids.
4. The ED50 of a drug refers to:
A. The dose required to produce a therapeutic effect in 50% of
the population
B. The dose required to produce a toxic effect in 50% of the
population
C. The dose at which 50% of the drug is metabolized
D. The dose required to achieve 50% of the maximal effect
3
, Correct Answer: A
Rationale: ED50 (Effective Dose) is the dose of a drug that
produces a specific therapeutic response in 50% of the test
population. It is a measure of drug potency.
5. A drug with a narrow therapeutic index (NTI) requires:
A. Less frequent monitoring
B. A high margin of safety
C. More stringent monitoring of serum levels
D. Higher initial loading doses
Correct Answer: C
Rationale: A narrow therapeutic index means there is a small
margin between the effective dose and the toxic dose. Serum
levels must be closely monitored to maintain efficacy and avoid
toxicity.
6. Which receptor type is associated with ligand-gated ion
channels?
4
COMPLETE QUESTIONS AND CORRECT DETAILED
ANSWERS (VERIFIED ANSWERS) ALREADY GRADED
A+|| NEW!!
1. A patient with a history of liver cirrhosis is prescribed a
medication that is highly metabolized by the liver. What
change in pharmacokinetics should the nurse anticipate?
A. Increased renal excretion
B. Decreased first-pass effect
C. Increased protein binding
D. Decreased half-life
Correct Answer: B
Rationale: Liver cirrhosis impairs hepatic function and blood
flow, leading to a significant reduction in first-pass metabolism.
This results in increased bioavailability of the drug. Protein
1
,binding is often decreased due to low albumin, and half-life is
typically prolonged.
2. The nurse is administering a drug that is a weak acid.
Which condition would promote the excretion of this drug in
the urine?
A. Alkalinization of the urine
B. Acidification of the urine
C. Decreased glomerular filtration rate
D. Increased active tubular reabsorption
Correct Answer: A
Rationale: "Ion trapping" dictates that weak acids are excreted
faster in alkaline urine. In an alkaline environment, the weak acid
dissociates into its ionized form, which is polar and less likely to
be reabsorbed in the renal tubules, thus promoting excretion.
3. A drug is administered intravenously and has a volume of
distribution (Vd) of 40 L. This indicates the drug:
2
,A. Is largely confined to the plasma
B. Is widely distributed into tissues
C. Is highly protein bound
D. Has a short duration of action
Correct Answer: B
Rationale: A standard Vd is about 4-5 L for plasma. A Vd of 40
L suggests the drug has left the plasma and is extensively
distributed into body tissues and fluids.
4. The ED50 of a drug refers to:
A. The dose required to produce a therapeutic effect in 50% of
the population
B. The dose required to produce a toxic effect in 50% of the
population
C. The dose at which 50% of the drug is metabolized
D. The dose required to achieve 50% of the maximal effect
3
, Correct Answer: A
Rationale: ED50 (Effective Dose) is the dose of a drug that
produces a specific therapeutic response in 50% of the test
population. It is a measure of drug potency.
5. A drug with a narrow therapeutic index (NTI) requires:
A. Less frequent monitoring
B. A high margin of safety
C. More stringent monitoring of serum levels
D. Higher initial loading doses
Correct Answer: C
Rationale: A narrow therapeutic index means there is a small
margin between the effective dose and the toxic dose. Serum
levels must be closely monitored to maintain efficacy and avoid
toxicity.
6. Which receptor type is associated with ligand-gated ion
channels?
4
