NEU 365W Exam 2 || A+ Guaranteed.
______ of people ages 15-54 have ever used alcohol correct answers 92%
____________ _______ is something that's found in all three of these categories: high income,
middle income, and low income countries correct answers alcohol use
In terms of the total number of productive or potential years of life lost, the number is around
________ _______________ years of life lost around the world correct answers 4.5 billion
A lower level of alcohol dependence in people 65+ might be because correct answers there are
those who may have died at a younger age due to alcoholism
Economic costs of alcohol abuse in the US: correct answers $185 billion
Why was alcohol safer to drink than water? correct answers Water often had a great amount of
bacteria and alcohol was more sterile
The gin craze was a result of: correct answers The Industrial Revolution
There is a higher alcohol consumption by ________ compared to ____________. correct
answers men; women
Potency increases for a type of alcohol as the _____________ ___________ ____________
increases. correct answers carbon chain backbone
Ethanol correct answers Low binding energy:
- Hydrogen bonding at -OH group
- Very weak hydrophobic interactions (-CH2CH3)
,- Low affinity interactions with proteins consistent with in vivo potency of 10-100 mM.
When you drink wine, all the alcohol that's absorbed out of your gut distributes into __________
_______ ___________ correct answers total body water
Absorption is more rapid and blood levels are much greater when alcohol is consumed on an
___________ _______________ - due to more rapid stomach emptying rate correct answers
empty stomach
_____________ _______________ ______________ markedly increased in people who have
developed pharmacokinetic tolerance to alcohol correct answers CYP2E enzyme activity
_____________ involves a single amino acid substitution (E to K) - homozygous individuals
have almost no ALDH2 activity. correct answers ALDH2*2
0.05 gm% correct answers Personality changes
Relief from anxiety
Social lubricant (more talkative, assertive, eloquent)
Disinhibition
0.08 gm% correct answers Significant Disinhibition ("life of the party")
Impaired judgment
Impaired cognition
Impaired motor function
0.15 gm% correct answers Marked ataxia (staggering; slurred speech)
Major motor impairment
Impaired reaction time
Blackouts
, 0.30 gm% correct answers Increased sedation/hypnosis (stuporous but conscious)
Approaching general anesthesia
Approaching coma
0.40 gm% correct answers Lethal dose for 50% of people
Ethanol increases _____________ responding at doses that decrease _______________
responding. correct answers punished; unpunished
______________ _____________ for reducing anxiety in humans is correlated with potency for
increasing punished responding in rats for drugs of different chemical structures. correct answers
Relative potency
Increasing severity of _____________ produces behaviors that are the opposite of increasing
_____________ ______ ________________ correct answers withdrawal; severity of
intoxication
Higher alcohol exposure or multiple withdrawals increase severity of ______________
___________ correct answers withdrawal signs
As the alcohol clears the body (withdrawal) __________ ___________________ is elevated (as
for all drugs of addiction) indicating a negative reward state. correct answers ICSS threshold
Alcohol tolerance is part of the __________ _______ criteria because: correct answers DSM V;
you're having more alcohol to drink than in the past to get the same effect
How long is the alcohol exposure required for development of tolerance? correct answers Hours,
days, months
______ of people ages 15-54 have ever used alcohol correct answers 92%
____________ _______ is something that's found in all three of these categories: high income,
middle income, and low income countries correct answers alcohol use
In terms of the total number of productive or potential years of life lost, the number is around
________ _______________ years of life lost around the world correct answers 4.5 billion
A lower level of alcohol dependence in people 65+ might be because correct answers there are
those who may have died at a younger age due to alcoholism
Economic costs of alcohol abuse in the US: correct answers $185 billion
Why was alcohol safer to drink than water? correct answers Water often had a great amount of
bacteria and alcohol was more sterile
The gin craze was a result of: correct answers The Industrial Revolution
There is a higher alcohol consumption by ________ compared to ____________. correct
answers men; women
Potency increases for a type of alcohol as the _____________ ___________ ____________
increases. correct answers carbon chain backbone
Ethanol correct answers Low binding energy:
- Hydrogen bonding at -OH group
- Very weak hydrophobic interactions (-CH2CH3)
,- Low affinity interactions with proteins consistent with in vivo potency of 10-100 mM.
When you drink wine, all the alcohol that's absorbed out of your gut distributes into __________
_______ ___________ correct answers total body water
Absorption is more rapid and blood levels are much greater when alcohol is consumed on an
___________ _______________ - due to more rapid stomach emptying rate correct answers
empty stomach
_____________ _______________ ______________ markedly increased in people who have
developed pharmacokinetic tolerance to alcohol correct answers CYP2E enzyme activity
_____________ involves a single amino acid substitution (E to K) - homozygous individuals
have almost no ALDH2 activity. correct answers ALDH2*2
0.05 gm% correct answers Personality changes
Relief from anxiety
Social lubricant (more talkative, assertive, eloquent)
Disinhibition
0.08 gm% correct answers Significant Disinhibition ("life of the party")
Impaired judgment
Impaired cognition
Impaired motor function
0.15 gm% correct answers Marked ataxia (staggering; slurred speech)
Major motor impairment
Impaired reaction time
Blackouts
, 0.30 gm% correct answers Increased sedation/hypnosis (stuporous but conscious)
Approaching general anesthesia
Approaching coma
0.40 gm% correct answers Lethal dose for 50% of people
Ethanol increases _____________ responding at doses that decrease _______________
responding. correct answers punished; unpunished
______________ _____________ for reducing anxiety in humans is correlated with potency for
increasing punished responding in rats for drugs of different chemical structures. correct answers
Relative potency
Increasing severity of _____________ produces behaviors that are the opposite of increasing
_____________ ______ ________________ correct answers withdrawal; severity of
intoxication
Higher alcohol exposure or multiple withdrawals increase severity of ______________
___________ correct answers withdrawal signs
As the alcohol clears the body (withdrawal) __________ ___________________ is elevated (as
for all drugs of addiction) indicating a negative reward state. correct answers ICSS threshold
Alcohol tolerance is part of the __________ _______ criteria because: correct answers DSM V;
you're having more alcohol to drink than in the past to get the same effect
How long is the alcohol exposure required for development of tolerance? correct answers Hours,
days, months
