MASTERY EXAM 2026 2027 EDITION
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Medical Terminology Final Exam (2026–2027 Edition)
1. A 45-year-old male presents to the emergency department
complaining of sharp, sudden pain in his upper right abdominal
quadrant after eating fatty meals. Diagnostic imaging confirms the
presence of several hard deposits obstructing the gallbladder neck.
The physician schedules the patient for a surgical excision of the
gallbladder. Which of the following terms correctly describes this
surgical procedure?
A) Cholecystostomy
B) Choledochotomy
C) Cholecystectomy
D) Cholecystopexy
Correct Answer: C
Rationale: The root cholecyst/ refers to the gallbladder, and the
suffix -ectomy means surgical removal or excision. Therefore, a
cholecystectomy is the surgical removal of the gallbladder. A
cholecystostomy is creating a temporary opening, and a
choledochotomy is an incision into the common bile duct.
2. A patient undergoes a comprehensive neurological evaluation due
to persistent muscle weakness and uncoordinated movement
patterns. The specialist notes that the patient is suffering from a
progressive degeneration of the brain tissue. Which medical term
translates literally to "softening of the brain"?
A) Encephalomalacia
B) Cerebrosclerosis
C) Myel dysplasia
D) Meningocele
, Correct Answer: A
Rationale: The combining form encephal/o means brain, and the
suffix -malacia means pathological softening. Combined,
encephalomalacia means the softening of brain tissue. Sclerosis
means hardening, and myel/o refers to the spinal cord or bone
marrow.
3. A liquid biopsy specimen is sent to the pathology laboratory to
screen for hematologic abnormalities. The automated analyzer
flags a profound drop in the patient's absolute leukocyte count,
rendering them highly susceptible to opportunistic bacterial
infections. Which of the following terms correctly identifies this
condition?
A) Leukocytosis
B) Leukopenia
C) Leukemia
D) Thrombocytopenia
Correct Answer: B
Rationale: The root leuk/o means white or white blood cell, and
the suffix -penia denotes an abnormal reduction, lack, or
deficiency. Thus, leukopenia is a deficiency of white blood cells.
Leukocytosis means an increase in white cells, and
thrombocytopenia is a deficiency of platelets.
4. A 67-year-old female with a long history of poorly controlled
hypertension undergoes a routine echocardiogram. The report
highlights a significant, compensatory abnormal enlargement of
the heart muscle walls, specifically within the left ventricle, to
combat systemic vascular resistance. Which term should the
clinician use to document this structural change?
A) Cardiomyopathy
B) Cardiomegaly
C) Myocarditis
D) Endocardiosis
Correct Answer: B
Rationale: The combining form cardi/o means heart, and the
suffix -megaly means abnormal enlargement. Cardiomegaly is
the clinical term for an enlarged heart. Cardiomyopathy is a
general disease of the heart muscle, and myocarditis is
inflammation of the heart muscle.
,5. A patient presents to the urgent care clinic displaying a severe rash
with deep lesions across the dermis of both lower limbs. The
physician notes that the clinical presentation indicates an active,
widespread inflammation of the skin. Which of the following terms
should be assigned?
A) Dermatosis
B) Dermabrasion
C) Dermatitis
D) Dermatofibroma
Correct Answer: C
Rationale: The root dermat/ means skin, and the suffix -itis
means inflammation. Dermatitis is the correct term for
inflammation of the skin. Dermatosis is a general non-
inflammatory skin disease, and dermabrasion is a scraping
procedure.
6. During a routine clinical workup for suspected
hyperparathyroidism, a physician orders a metabolic panel. The
laboratory results reveal that the patient has an abnormally high
concentration of calcium circulating within the blood plasma.
Which medical term accurately describes this finding?
A) Hypokalemia
B) Hypernatremia
C) Hypercalcemia
D) Hypoglycemia
Correct Answer: C
Rationale: The prefix hyper- means excessive or above normal,
the root calc/ refers to calcium, and the suffix -emia means a
blood condition. Hypercalcemia is an excessive amount of calcium
in the blood. Hypokalemia refers to low potassium, and
hypernatremia refers to high sodium.
7. A patient is rushed to the operating room for an emergency
exploratory procedure after sustaining blunt force trauma to the
abdomen in a motor vehicle accident. The trauma surgeon must
create a surgical incision directly through the abdominal wall to
inspect the internal organs for hidden hemorrhage. What is the
correct term for this procedure?
A) Laparoscopy
B) Laparotomy
C) Abdominocentesis
, D) Colostomy
Correct Answer: B
Rationale: The combining form lapar/o means abdominal wall or
flank, and the suffix -tomy means an incision or cutting into. A
laparotomy is an incision into the abdominal cavity. Laparoscopy
is visual examination using a scope, and abdominocentesis is
surgical puncture to drain fluid.
8. An ENT specialist examines a 12-year-old child who has
experienced recurrent episodes of epistaxis (nosebleeds) and
chronic breathing difficulties. The examination reveals a marked
structural deviation of the internal cartilage partition that
separates the nasal cavities. Which term describes this specific
partition?
A) Nasal septum
B) Nasal turbinate
C) External nares
D) Paranasal sinus
Correct Answer: A
Rationale: The word septum refers to a dividing wall or partition.
The nasal septum is the cartilage and bone structure that
separates the left and right nasal cavities. Turbinates are shell-
like bones inside the nose, and nares are the nostrils.
9. A patient with advanced pulmonary emphysema presents to the
emergency department displaying cyanosis around the lips and
fingertips. Arterial blood gas monitoring demonstrates an
abnormally low level of oxygen saturation circulating throughout
the systemic arterial blood. Which term accurately identifies this
pathological state?
A) Hypoxia
B) Hypoxemia
C) Hypercapnia
D) Apnea
Correct Answer: B
Rationale: The prefix hypo- means below normal or deficient, ox/
refers to oxygen, and the suffix -emia specifies a blood condition.
Hypoxemia is a lack of oxygen in the blood. Hypoxia is a general
lack of oxygen at the tissue level, and hypercapnia is excessive
carbon dioxide.