NR 547 Week 6 SI Questions And
Verified Answers- Chamberlain
University, Illinois
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Genetics AD - Answer: Genes play a strong role- heritability of 58-79% for late onset and over
90% for early onset
WHAT ARE THE TWO HALLMARKS OF AD? - Answer: amyloid plaques and neurofibrillary
tangles -•Responsible for issues with memory and higher-level thinking
Neural networks AD - Answer: Damage to synapses, mitochondrial abnormalities, and
inflammatory processes cause NTM failure and neuronal death
NTM responsible for memory and learning - Answer: ACh
Does AD lead to an increase or decrease in this NTM activity - Answer: Leads to a decrease in
NTM activity
Decreased ACh leads to - Answer: a permanent loss of cholinergic neurons= this causes short
term memory dysfunction
Cholinesterase inhibitors examples - Answer: Donepezil
Rivastigmine
, Galantamine
Cholinesterase inhibitors - Answer: alleviate symptoms, do not stop progression
Increase levels of ACH
Improves cognition which improves memory and thinking
Donepezil (Aricept) - Answer: inhibits centrally active ACH• Higher doses cause higher
incidence of adverse effects
Cholinesterase inhibitors - What happens when added to CYP2D6 or 3A4? - Answer:
possibility of peripheral side effects
•Rivastigmine (Exelon) - Answer: increases efficacy of both acetylcholinesterase and
butyrylcholinesterase
Medications that reduce or inhibit CYP450 metabolism will not affect rivastigmine
metabolism
Galantamine (Razadyne, Razadyne ER) - Answer: elevates ACH in the cerebral cortex to
increase Ach release from existing presynaptic nerve terminals. Also increases Glu and 5HT
Cannot be used concurrently with NSAIDS or medications that slow or decrease HR.
Memantine
N-Methyl-D-Aspartate Receptor Antagonist - Answer: •NMDA receptor antagonist
•Only approved medication to manage moderate- severe AD
•Works by preventing glutamate binding at the receptor site and regulates how much calcium
enters the nerve cell
•Blocking NMDA receptors protects neurons from the effects of too much Glu
Verified Answers- Chamberlain
University, Illinois
Premium Online Exam & Class Management Services
Professional • Confidential • Reliable • Results-Oriented
WHY STUDENTS CHOOSE US
Professional management of online classes
Support for proctored examinations
Assignment and coursework coordination
Quiz, test and assessment assistance
Fast communication and timely updates
Strict confidentiality and privacy
SERVICES OFFERED
✓ Online Class Management
✓ Proctored Exam Handling
✓ Weekly Discussion Participation
✓ Coursework Tracking
✓ Academic Scheduling Support
✓ Exam Preparation Guidance
, CONTACT US TODAY
📧
📧 WhatsApp: +254799356524
🔗 https://wa.me/254799356524
EXCELLENCE • EFFICIENCY • CONFIDENTIALITY
Genetics AD - Answer: Genes play a strong role- heritability of 58-79% for late onset and over
90% for early onset
WHAT ARE THE TWO HALLMARKS OF AD? - Answer: amyloid plaques and neurofibrillary
tangles -•Responsible for issues with memory and higher-level thinking
Neural networks AD - Answer: Damage to synapses, mitochondrial abnormalities, and
inflammatory processes cause NTM failure and neuronal death
NTM responsible for memory and learning - Answer: ACh
Does AD lead to an increase or decrease in this NTM activity - Answer: Leads to a decrease in
NTM activity
Decreased ACh leads to - Answer: a permanent loss of cholinergic neurons= this causes short
term memory dysfunction
Cholinesterase inhibitors examples - Answer: Donepezil
Rivastigmine
, Galantamine
Cholinesterase inhibitors - Answer: alleviate symptoms, do not stop progression
Increase levels of ACH
Improves cognition which improves memory and thinking
Donepezil (Aricept) - Answer: inhibits centrally active ACH• Higher doses cause higher
incidence of adverse effects
Cholinesterase inhibitors - What happens when added to CYP2D6 or 3A4? - Answer:
possibility of peripheral side effects
•Rivastigmine (Exelon) - Answer: increases efficacy of both acetylcholinesterase and
butyrylcholinesterase
Medications that reduce or inhibit CYP450 metabolism will not affect rivastigmine
metabolism
Galantamine (Razadyne, Razadyne ER) - Answer: elevates ACH in the cerebral cortex to
increase Ach release from existing presynaptic nerve terminals. Also increases Glu and 5HT
Cannot be used concurrently with NSAIDS or medications that slow or decrease HR.
Memantine
N-Methyl-D-Aspartate Receptor Antagonist - Answer: •NMDA receptor antagonist
•Only approved medication to manage moderate- severe AD
•Works by preventing glutamate binding at the receptor site and regulates how much calcium
enters the nerve cell
•Blocking NMDA receptors protects neurons from the effects of too much Glu
