ABBAS - CELLULAR AND MOLECULAR IMMUNOLOGY
1. Selectins are...: ...membrane carbohydrate-binding adhesion molecules that mediate the
initial step of low-aflnit adhesion of circulating leukocytes to endothelial cells.
2. Selectins bind...: ... carbohydrate structures in a calcium-dependent manner.
3. Selectins on endothelial cells include...: E- and P-selectins
4. Selectins and selectin ligands on leukocytes include...: 1) Sialylated
carbohydrate groups (including Lewis A and X).
2) P-selectin glycoprotein ligand 1 (PSGL-1)
3) L-selectin (CD62L) -> ensures homing to lymph nodes
5. Integrins are...: 1) ... heterodimeric cell surface proteins combosed of linked
polypeptide chains that mediate adhesion of cells to other cells or the extracellular matrix.
2) Over 30 integrins are known
3) Their cytoplasmic domains bind to cytoskeletal components, including: vinculin, talin, actin, a-actinin,
tropomyosin
4) They attect cell shape, motility and phagocytosis
6. Integrins have important features that include...: 1) ability to quickly
change their aflnity for their ligands
2) this is mediated through chemokine-signaling
3) clustering, which increases their concentrations and hence, their avidity -> tighter binding.
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1. Selectins are...: ...membrane carbohydrate-binding adhesion molecules that mediate the
initial step of low-aflnit adhesion of circulating leukocytes to endothelial cells.
2. Selectins bind...: ... carbohydrate structures in a calcium-dependent manner.
3. Selectins on endothelial cells include...: E- and P-selectins
4. Selectins and selectin ligands on leukocytes include...: 1) Sialylated
carbohydrate groups (including Lewis A and X).
2) P-selectin glycoprotein ligand 1 (PSGL-1)
3) L-selectin (CD62L) -> ensures homing to lymph nodes
5. Integrins are...: 1) ... heterodimeric cell surface proteins combosed of linked
polypeptide chains that mediate adhesion of cells to other cells or the extracellular matrix.
2) Over 30 integrins are known
3) Their cytoplasmic domains bind to cytoskeletal components, including: vinculin, talin, actin, a-actinin,
tropomyosin
4) They attect cell shape, motility and phagocytosis
6. Integrins have important features that include...: 1) ability to quickly
change their aflnity for their ligands
2) this is mediated through chemokine-signaling
3) clustering, which increases their concentrations and hence, their avidity -> tighter binding.
1/
4
