NBME CBSE MEDICAL SCIENCES
COMPREHENSIVE PRACTICE QUESTIONS -
VERSION 2026\27 |COMPLETE STUDY
GUIDE.
What is the expected beneficial effect of bisphosphonates in osteoporosis? -
Accurate answer Decreased osteoclast activity
What is the relative risk ratio for hip fractures among elderly women who exercise
regularly? -Accurate answer 1.2 (95% confidence interval of 1.1 to 1.8)
What is the most immediate treatment mechanism of action for chest pain
radiating to the jaw? -Accurate answer Increased nitric oxide concentration
What causes the formation of tissue in a wound from hot grease? -Accurate
answer Increased activity of Vascular Endothelial Growth Factor (VEGF), which
stimulates angiogenesis
What is the effect of desmopressin on urine osmolarity? -Accurate answer
Increases urine osmolarity due to activation of adenylyl cyclase
What is the likely infectious agent in a child with fever, cough, and wheezing who
attends daycare? -Accurate answer An agent that mediates cell entry via a fusion
protein
What pharmacotherapy is most appropriate for a patient with mild wheezing after
a bee sting? -Accurate answer B2-agonist
,What is the diagnosis for a 14-year-old boy with a sore throat, fever, and cervical
lymphadenopathy? -Accurate answer Infectious Mononucleosis
What phase of the cell cycle is defective in a tumor that continues to grow despite
radiation therapy? -Accurate answer G1 phase
What is the diagnosis for a patient with bilateral hydroureter and hydronephrosis,
who lived in sub-Saharan Africa? -Accurate answer Schistosomiasis
What is the expected percentage of offspring with a two-gene deletion from a
couple with a-thalassemia? -Accurate answer 50%
What is the diagnosis for a previously healthy 40-year-old woman with fever,
lethargy, and low platelets? -Accurate answer Thrombotic Thrombocytopenic
Purpura
What is the diagnosis for a 16-year-old boy with a knife wound to the chest
showing air-fluid levels? -Accurate answer Hemopneumothorax
What are the effects of atorvastatin and losartan on HDL and triglycerides? -
Accurate answer HDL increased, triglycerides decreased
What vitamin deficiency is indicated by diffuse weakness and decreased sensation
in a 73-year-old woman? -Accurate answer Vitamin B12 deficiency
(cyanocobalamin)
, What is the underlying cause of acne in a 15-year-old girl? -Accurate answer
Stimulation of sebaceous glands by androgens
What process is indicated by a biopsy of a lesion in the jaw that resembles
Burkitt's lymphoma? -Accurate answer Apoptosis
What lymph nodes should be evaluated first for metastasis in a patient with a
tongue mass? -Accurate answer Submental lymph nodes
What pathogen is indicated by cysts and trophozoites found in a lumbar puncture
of a patient with confusion and agitation? -Accurate answer Naegleria fowleri
What drug is likely ingested by a patient showing hostility and rigidity after being
found with a blank stare? -Accurate answer PCP (Phencyclidine)
What is the likely result of a clinical trial with alpha set at 0.01 instead of 0.05? -
Accurate answer Significant findings can be reported with greater confidence
What is the cause of amenorrhea in a 17-year-old gymnast with a BMI of 15? -
Accurate answer Low body weight leading to hormonal imbalance
What is hypogonadotropic hypogonadism? -Accurate answer A condition
characterized by low levels of sex hormones due to insufficient stimulation from
the pituitary gland.
COMPREHENSIVE PRACTICE QUESTIONS -
VERSION 2026\27 |COMPLETE STUDY
GUIDE.
What is the expected beneficial effect of bisphosphonates in osteoporosis? -
Accurate answer Decreased osteoclast activity
What is the relative risk ratio for hip fractures among elderly women who exercise
regularly? -Accurate answer 1.2 (95% confidence interval of 1.1 to 1.8)
What is the most immediate treatment mechanism of action for chest pain
radiating to the jaw? -Accurate answer Increased nitric oxide concentration
What causes the formation of tissue in a wound from hot grease? -Accurate
answer Increased activity of Vascular Endothelial Growth Factor (VEGF), which
stimulates angiogenesis
What is the effect of desmopressin on urine osmolarity? -Accurate answer
Increases urine osmolarity due to activation of adenylyl cyclase
What is the likely infectious agent in a child with fever, cough, and wheezing who
attends daycare? -Accurate answer An agent that mediates cell entry via a fusion
protein
What pharmacotherapy is most appropriate for a patient with mild wheezing after
a bee sting? -Accurate answer B2-agonist
,What is the diagnosis for a 14-year-old boy with a sore throat, fever, and cervical
lymphadenopathy? -Accurate answer Infectious Mononucleosis
What phase of the cell cycle is defective in a tumor that continues to grow despite
radiation therapy? -Accurate answer G1 phase
What is the diagnosis for a patient with bilateral hydroureter and hydronephrosis,
who lived in sub-Saharan Africa? -Accurate answer Schistosomiasis
What is the expected percentage of offspring with a two-gene deletion from a
couple with a-thalassemia? -Accurate answer 50%
What is the diagnosis for a previously healthy 40-year-old woman with fever,
lethargy, and low platelets? -Accurate answer Thrombotic Thrombocytopenic
Purpura
What is the diagnosis for a 16-year-old boy with a knife wound to the chest
showing air-fluid levels? -Accurate answer Hemopneumothorax
What are the effects of atorvastatin and losartan on HDL and triglycerides? -
Accurate answer HDL increased, triglycerides decreased
What vitamin deficiency is indicated by diffuse weakness and decreased sensation
in a 73-year-old woman? -Accurate answer Vitamin B12 deficiency
(cyanocobalamin)
, What is the underlying cause of acne in a 15-year-old girl? -Accurate answer
Stimulation of sebaceous glands by androgens
What process is indicated by a biopsy of a lesion in the jaw that resembles
Burkitt's lymphoma? -Accurate answer Apoptosis
What lymph nodes should be evaluated first for metastasis in a patient with a
tongue mass? -Accurate answer Submental lymph nodes
What pathogen is indicated by cysts and trophozoites found in a lumbar puncture
of a patient with confusion and agitation? -Accurate answer Naegleria fowleri
What drug is likely ingested by a patient showing hostility and rigidity after being
found with a blank stare? -Accurate answer PCP (Phencyclidine)
What is the likely result of a clinical trial with alpha set at 0.01 instead of 0.05? -
Accurate answer Significant findings can be reported with greater confidence
What is the cause of amenorrhea in a 17-year-old gymnast with a BMI of 15? -
Accurate answer Low body weight leading to hormonal imbalance
What is hypogonadotropic hypogonadism? -Accurate answer A condition
characterized by low levels of sex hormones due to insufficient stimulation from
the pituitary gland.
