UAMS HEMATOLOGY TEST PAPER 5 2026
COMPLETE QUESTIONS AND SOLUTIONS
GRADED A+
●● A patient has a platelet count of 700 x 103 per microliter, with
abnormalities in size, shape, granularity of platelets; a WBC count of 12
x 103 per microliter, and hemoglobin of 11 g/dL. The Philadelphia
chromosome is not present. What is the likely diagnosis?
Answer: Essential Thrombocythemia
●● A patient has a WBC count of 30 x 103 per microliter with the
following differential results:
Segmented Neutrophil: 38%
Bands: 17%
Metamyelocytes: 7%
Myelocytes: 20%
Promyelocytes: 10%
Eosinophils: 3%
Basophils: 5%
Which of the following test results would be helpful in determining
whether the patient has CML?
Answer: Positive for BCR/ABL 1 fusion
,●● The most common mutation found in patients with polycythemia
vera is
Answer: JAK2 V617F
●● Which of the following chromosome abnormalities is associated with
CML?
Answer: t(9:22)
●● The cytochemical stain alpha napthol butyrate is a nonspecific
esterase stain that shows diffuse positivity in cells of which lineage?
Answer: Monocytic
●● Which classification of AML would have diffusely positive staining
patterns in myeloperoxidase, sudan black B, specific esterase and non
specific esterase?
Answer: M4
●● In most cases the diagnosis of lymphoma relies on all of the
following except:
Answer: Peripheral blood examination and a complete blood count
●● Which condition is associated with an accumulation of malignant
plasma cells in the bone marrow presenting as lytic bone lesions, and is
, also associated with excess production of immunoglobulins, which can
be detected in the urine and serum (monoclonal gammopathy)?
Answer: Multiple myeloma
●● Which condition presents as a disseminated disease with widespread
skin involvement associated with Mycosis Fungiodes, lymphadenopathy,
and circulating lymphoma cells with characteristic cerebriform nuclei?
Answer: Sezary syndrome
●● Left shift, dohle bodies and toxic granulation is observed
Answer: Bacterial infection
●● Benign reactive lymphocytes
Answer: Viral infection
●● Adult hemoglobin greater than 19 g/dL; Low erythropoietin
Answer: Polycythemia vera
●● Platelet count usually exceeds one million
Answer: Essential thrombocythemia
●● Increased red cell mass
Answer: Polycythemia vera
COMPLETE QUESTIONS AND SOLUTIONS
GRADED A+
●● A patient has a platelet count of 700 x 103 per microliter, with
abnormalities in size, shape, granularity of platelets; a WBC count of 12
x 103 per microliter, and hemoglobin of 11 g/dL. The Philadelphia
chromosome is not present. What is the likely diagnosis?
Answer: Essential Thrombocythemia
●● A patient has a WBC count of 30 x 103 per microliter with the
following differential results:
Segmented Neutrophil: 38%
Bands: 17%
Metamyelocytes: 7%
Myelocytes: 20%
Promyelocytes: 10%
Eosinophils: 3%
Basophils: 5%
Which of the following test results would be helpful in determining
whether the patient has CML?
Answer: Positive for BCR/ABL 1 fusion
,●● The most common mutation found in patients with polycythemia
vera is
Answer: JAK2 V617F
●● Which of the following chromosome abnormalities is associated with
CML?
Answer: t(9:22)
●● The cytochemical stain alpha napthol butyrate is a nonspecific
esterase stain that shows diffuse positivity in cells of which lineage?
Answer: Monocytic
●● Which classification of AML would have diffusely positive staining
patterns in myeloperoxidase, sudan black B, specific esterase and non
specific esterase?
Answer: M4
●● In most cases the diagnosis of lymphoma relies on all of the
following except:
Answer: Peripheral blood examination and a complete blood count
●● Which condition is associated with an accumulation of malignant
plasma cells in the bone marrow presenting as lytic bone lesions, and is
, also associated with excess production of immunoglobulins, which can
be detected in the urine and serum (monoclonal gammopathy)?
Answer: Multiple myeloma
●● Which condition presents as a disseminated disease with widespread
skin involvement associated with Mycosis Fungiodes, lymphadenopathy,
and circulating lymphoma cells with characteristic cerebriform nuclei?
Answer: Sezary syndrome
●● Left shift, dohle bodies and toxic granulation is observed
Answer: Bacterial infection
●● Benign reactive lymphocytes
Answer: Viral infection
●● Adult hemoglobin greater than 19 g/dL; Low erythropoietin
Answer: Polycythemia vera
●● Platelet count usually exceeds one million
Answer: Essential thrombocythemia
●● Increased red cell mass
Answer: Polycythemia vera
