NCLEX Pharmacology 2026
150+ Drug-Based Questions with Rationales
1. A patient is prescribed insulin. What is the main action?
A. Increase glucose
B. Decrease glucose
C. Increase BP
D. Decrease oxygen
Answer: B
Rationale: Insulin lowers blood glucose levels.
2. A patient on Aspirin reports stomach pain. What is concern?
A. Infection
B. GI irritation
C. Recovery
D. Sleep
Answer: B
Rationale: Aspirin can cause gastric irritation.
3. A patient receives Morphine. What is priority assessment?
A. BP
B. Respiratory rate
C. Temperature
D. Urine output
Answer: B
Rationale: Risk of respiratory depression.
4. A patient is taking Furosemide. What should nurse monitor?
A. Sodium
B. Potassium
C. Glucose
D. Calcium
, Answer: B
Rationale: Causes potassium loss.
5. A patient is on Digoxin. What is toxicity sign?
A. Vision changes
B. Fever
C. Dry skin
D. Calmness
Answer: A
Rationale: Yellow vision is classic sign.
6. A patient takes Warfarin. What lab is monitored?
A. BP
B. INR
C. Glucose
D. Pulse
Answer: B
Rationale: Measures clotting time.
7. A patient is on Metformin. What is side effect?
A. Hypoglycemia
B. Lactic acidosis
C. Hypertension
D. Fever
Answer: B
Rationale: Rare but serious effect.
8. A patient receives Paracetamol. What should be monitored?
A. Kidney
B. Liver
C. Heart
D. Lungs
Answer: B
Rationale: Hepatotoxic in high doses.
,9. A patient takes Heparin. What is antidote?
A. Vitamin K
B. Protamine sulfate
C. Insulin
D. Glucose
Answer: B
Rationale: Reverses heparin effect.
10. A patient is on Amoxicillin. What is common side effect?
A. Rash
B. Hair loss
C. Sleep
D. Calmness
Answer: A
Rationale: Allergic reactions possible.
11. A patient takes Atorvastatin. What is risk?
A. Muscle pain
B. Fever
C. Dry skin
D. Sleep
Answer: A
Rationale: Risk of myopathy.
12. A patient is on Lisinopril. What is side effect?
A. Dry cough
B. Fever
C. Rash
D. Sleep
Answer: A
Rationale: ACE inhibitors cause cough.
13. A patient receives Salbutamol. What is effect?
A. Constrict airway
B. Dilate airway
, C. Reduce BP
D. Increase glucose
Answer: B
Rationale: Opens airways.
14. A patient takes Omeprazole. What is use?
A. Reduce acid
B. Increase acid
C. Pain relief
D. Sleep
Answer: A
Rationale: Treats GERD.
15. A patient is on Diazepam. What is effect?
A. Anxiety relief
B. Fever
C. Infection
D. BP increase
Answer: A
Rationale: Sedative and anxiolytic.
16. A patient takes Hydrochlorothiazide. What should be monitored?
A. Potassium
B. Glucose
C. Calcium
D. Oxygen
Answer: A
Rationale: Causes potassium loss.
17. A patient receives Ceftriaxone. What is use?
A. Viral infection
B. Bacterial infection
C. Pain
D. Sleep
150+ Drug-Based Questions with Rationales
1. A patient is prescribed insulin. What is the main action?
A. Increase glucose
B. Decrease glucose
C. Increase BP
D. Decrease oxygen
Answer: B
Rationale: Insulin lowers blood glucose levels.
2. A patient on Aspirin reports stomach pain. What is concern?
A. Infection
B. GI irritation
C. Recovery
D. Sleep
Answer: B
Rationale: Aspirin can cause gastric irritation.
3. A patient receives Morphine. What is priority assessment?
A. BP
B. Respiratory rate
C. Temperature
D. Urine output
Answer: B
Rationale: Risk of respiratory depression.
4. A patient is taking Furosemide. What should nurse monitor?
A. Sodium
B. Potassium
C. Glucose
D. Calcium
, Answer: B
Rationale: Causes potassium loss.
5. A patient is on Digoxin. What is toxicity sign?
A. Vision changes
B. Fever
C. Dry skin
D. Calmness
Answer: A
Rationale: Yellow vision is classic sign.
6. A patient takes Warfarin. What lab is monitored?
A. BP
B. INR
C. Glucose
D. Pulse
Answer: B
Rationale: Measures clotting time.
7. A patient is on Metformin. What is side effect?
A. Hypoglycemia
B. Lactic acidosis
C. Hypertension
D. Fever
Answer: B
Rationale: Rare but serious effect.
8. A patient receives Paracetamol. What should be monitored?
A. Kidney
B. Liver
C. Heart
D. Lungs
Answer: B
Rationale: Hepatotoxic in high doses.
,9. A patient takes Heparin. What is antidote?
A. Vitamin K
B. Protamine sulfate
C. Insulin
D. Glucose
Answer: B
Rationale: Reverses heparin effect.
10. A patient is on Amoxicillin. What is common side effect?
A. Rash
B. Hair loss
C. Sleep
D. Calmness
Answer: A
Rationale: Allergic reactions possible.
11. A patient takes Atorvastatin. What is risk?
A. Muscle pain
B. Fever
C. Dry skin
D. Sleep
Answer: A
Rationale: Risk of myopathy.
12. A patient is on Lisinopril. What is side effect?
A. Dry cough
B. Fever
C. Rash
D. Sleep
Answer: A
Rationale: ACE inhibitors cause cough.
13. A patient receives Salbutamol. What is effect?
A. Constrict airway
B. Dilate airway
, C. Reduce BP
D. Increase glucose
Answer: B
Rationale: Opens airways.
14. A patient takes Omeprazole. What is use?
A. Reduce acid
B. Increase acid
C. Pain relief
D. Sleep
Answer: A
Rationale: Treats GERD.
15. A patient is on Diazepam. What is effect?
A. Anxiety relief
B. Fever
C. Infection
D. BP increase
Answer: A
Rationale: Sedative and anxiolytic.
16. A patient takes Hydrochlorothiazide. What should be monitored?
A. Potassium
B. Glucose
C. Calcium
D. Oxygen
Answer: A
Rationale: Causes potassium loss.
17. A patient receives Ceftriaxone. What is use?
A. Viral infection
B. Bacterial infection
C. Pain
D. Sleep
