PCB 3233 Exam 3 Study Guide Chapters 5 and 6 Questions With Correct Answers

PCB 3233 Exam 3 Study Guide Chapters 5 and 6 Questions
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With Correct Answers
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1. //BCR //(B //cell //receptor) //and //TCR //(T //cell //receptor), //how //are //they //created //and

wherein //the //body //are //they //created? //- //CORRECT //ANSWERS(S)✔✔BCR

: //created //through //somatic //recombination //creating //variability //in //the //variable

region //domain //of //heavy //and //light //chains, //created //in //the //bone //marrow. //Additions

before //antigen //encounter, //BCRs //use //RNA //splicing //for //IgM //and //IgD //and //after

antigen //encounter, //RNA //splicing //is //used //again //to //secrete //Ig, //somatic //hypermutation

occurs //to //make //antibodies //have //higher //affinity //causing //affinity //maturation //and //C

region //DNA //rearrangement //occurs //through //isotype //switching

TCR

: //created //through //ONLY //somatic //recombination //creating //variability //in //the

variable //region //domain //of //the //heavy //and //light //chains, //created //in //the //bone //marrow

and //sent //out //to //the //thymus //to //mature //to //become //a //T //cell



2. //Structure //of //immunoglobulin //and //T //cell //receptor //(TCR) //- //CORRECT
ANSWERS(S)✔✔Immunoglobulin
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:Variable //and //constant //heavy //and //light //chains, //2 //regions //which

include //the //2 //Fab, //which //is //the //recognition //function //in //the //binding //site, //and //the //Fc

region, //or //the //constant //function, //dictates //the //effector //function //. //Plus, //it //is

secreted //or //membrane //bound

TCR

: //membrane //bound //glycoprotein //resembling //a //single //antigen //binding //arm //of //an

Ig. //TCRs //consist //of //2 //polypeptides //( //and //chain). //These //polypeptide //chains //are //∝ //𝛃

, apart //of //the //innate //immune //system //that //encode //genes. //It //has //one //antigen //binding

site. //It //also //has //a //variable //and //constant //regions



3. //The //T //cell //receptor //(TCR) //type //of //antigen //vs. //Ig //(BCR) //type //of //antigen //- //CORRECT
//ANSWERS(S)✔✔the //internal //environment //(in //all //nucleated //cells, //except //erythrocytes).
//MHC //class //II



samples //from //the //external //environment. //TCRs //can //only //bind //to //linear //peptides //or

proteins

BCR

: //the //BCR //can //bind //to //anything //such //as //proteins, //polysaccharides //and //lipids //and

don't //require //presentation. //Therefore, //they //only //have //a //binary //binding //complex //of

the //epitope //and //binding //site. //They //can //bind //to //accessible //peptides //that //are //linear

or //discontinuous



4. //For //expression //of //the //TCR //at //the //cell //surface //what //is //needed? //(list //all //proteins

and //the //name //given //to //all //the //proteins //and //TCR //when //on //the //surface). //- //CORRECT
//ANSWERS(S)✔✔Since //the //TCR //is //an //and //heterodimer, //it //cannot //be //stable //enough //to
//leave //the //∝ //𝛃



ER. //There //are //4 //"invariant" //membrane //proteins

- //2 //CD3 //complex

- //1st //CD3 //complex //on //chromosome //11 //consisting //of //delta //(δ) //and //epsilon

(ε) //domains

- //2nd //CD3 //complex //on //chromosome //11 //consisting //of //gamma //( //) //and //ˠ

epsilon //(ε)

- //2 //zeta //chains //from //chromosome //1 //) //(helps //with //signaling)(𝛇

Lack //of //these //CD3 //leads //to //low //TCR //expression //and //immunodeficiency