Immunity during pregnancy
,Immunologically privileged organs
anatomical sites, which implanted graft under
certain conditions is not rejected (if there is no
vascularization of the graft)
Classic immunologically privileged organs are:
The internal chamber of the eye
The brain
testes
ovary
Hair follicles
Pregnant uterus
, Features of
immunologically privileged organs
▪ Isolation (locally)
Tissue barrier (formed by endothelial, mesothelial
or epithelial cells)
The lack of lymphatic drainage (to the immune
system is not received information about the
antigenic composition of these bodies)
, Features of
immunologically privileged organs
▪ Immunosuppression (at local level):
Lack of antigen-presenting cells
The presence of local immunosuppressive
factors
✔ humoral: cytokines – TGF-β, IL-10, complement
system, hormones and neuropeptides
(somatostatin, calcitonin, ACTH, melanocyte-
stimulating hormone);
✔ cells: a large number of Treg, low APC expressing
MHC class II
,Immunologically privileged organs
anatomical sites, which implanted graft under
certain conditions is not rejected (if there is no
vascularization of the graft)
Classic immunologically privileged organs are:
The internal chamber of the eye
The brain
testes
ovary
Hair follicles
Pregnant uterus
, Features of
immunologically privileged organs
▪ Isolation (locally)
Tissue barrier (formed by endothelial, mesothelial
or epithelial cells)
The lack of lymphatic drainage (to the immune
system is not received information about the
antigenic composition of these bodies)
, Features of
immunologically privileged organs
▪ Immunosuppression (at local level):
Lack of antigen-presenting cells
The presence of local immunosuppressive
factors
✔ humoral: cytokines – TGF-β, IL-10, complement
system, hormones and neuropeptides
(somatostatin, calcitonin, ACTH, melanocyte-
stimulating hormone);
✔ cells: a large number of Treg, low APC expressing
MHC class II
