NR 507 ADVANCED PATHOPHYSIOLOGY
MIDTERM PRACTICE SCRIPT 2026 QUESTIONS
WITH SOLUTIONS
◉ Type 1 hypersensitivity reactions are mediated by what. Answer:
IgE
◉ What cells are involved in hypersensitivity type 1. Answer: Mast
cells
◉ symptoms of hypersensitivity type 1. Answer: local: itching,
immediate rash
systemic: wheezing
◉ main treatment for anaphylaxis. Answer: epinephrine
◉ Type 2 hypersensitivity is also known as what kind of reaction?.
Answer: cytoctoxic reaction, tissue specific
◉ what cells are involved in type 2 hypersensitivity reaction?.
Answer: Macrophages
, ◉ what does type 2 hypersensitivity do to tissues?. Answer: can
cause damage or alter function of specific tissues
◉ Examples of hypersensitivity type 2. Answer: graves disease/
hyperthyroidism, blood incompatibility
◉ what is the difference between type 2 and 3 hypersensitivity?.
Answer: type 2 is organ specific; antibody binds to the antigen on
the surface of the cell
type 3 is NOT organ specific; binds outside of the cell surface and is
released into blood/ body fluids and then deposited into tissues
◉ examples of type 3 hypersensitivity. Answer: rheumatoid arthritis
and lupus
◉ autoimmune diseases can be.... Answer: genetic/familial
◉ What is alloimmunity?. Answer: Immune reaction to tissues of
another individual
◉ Examples of alloimmunity. Answer: transplant rejection,
transfusion reactions, Rh incompatibility
MIDTERM PRACTICE SCRIPT 2026 QUESTIONS
WITH SOLUTIONS
◉ Type 1 hypersensitivity reactions are mediated by what. Answer:
IgE
◉ What cells are involved in hypersensitivity type 1. Answer: Mast
cells
◉ symptoms of hypersensitivity type 1. Answer: local: itching,
immediate rash
systemic: wheezing
◉ main treatment for anaphylaxis. Answer: epinephrine
◉ Type 2 hypersensitivity is also known as what kind of reaction?.
Answer: cytoctoxic reaction, tissue specific
◉ what cells are involved in type 2 hypersensitivity reaction?.
Answer: Macrophages
, ◉ what does type 2 hypersensitivity do to tissues?. Answer: can
cause damage or alter function of specific tissues
◉ Examples of hypersensitivity type 2. Answer: graves disease/
hyperthyroidism, blood incompatibility
◉ what is the difference between type 2 and 3 hypersensitivity?.
Answer: type 2 is organ specific; antibody binds to the antigen on
the surface of the cell
type 3 is NOT organ specific; binds outside of the cell surface and is
released into blood/ body fluids and then deposited into tissues
◉ examples of type 3 hypersensitivity. Answer: rheumatoid arthritis
and lupus
◉ autoimmune diseases can be.... Answer: genetic/familial
◉ What is alloimmunity?. Answer: Immune reaction to tissues of
another individual
◉ Examples of alloimmunity. Answer: transplant rejection,
transfusion reactions, Rh incompatibility
