PCB 4233 EXAM 3 STUDY GUIDE

PCB 4233 EXAM 3 STUDY GUIDE

Evasion and Subversion of Intracellular Bacteria - Answers -sheltered in macrophages
- block of phagosome lysosome fusion
- escape in cytosol
- resistant to phagolysosome
Elicit type I immune response
- NK cells, TH1
CD8 Ts induced by bacteria escape to cytosol

Evasion by Protozoa Parasites - Answers -Intermediate host
Direct delivery into blood, bypass of barriers
- Sleep sickness
- antigenic variation: variant specific glycoprotein

- Plasmodium: malaria
- antigen variation
- switch host cell types

- Leishmania major
- inhibition of IL-12 production, weak Type I response

Influenza - Answers -Rapid mutation of genome
Neutralize antibodies, Tcs

- Antigenic drift
mutation and mild change

- Antigenic shift
reassortment of segmented genome, major change in HA

HCV - Answers -RNA virus
high mutation rate in immune epitopes

-difficult to generate neutralizing antibodies
- highly glycosylated surface protein
- high mutation rate

USE IFN gamma AS ANTIVIRAL; inhibitors of HCV nonstructural proteins

DNA Virus - Answers -adeno virus, poxvirus, herpesvirus: low mutation rate, large
genome

Herpes:
1) HSV1/2, cold sore, genital herpes