Tox 300 Final Exam Questions With Correct
Answers
Organophosphates, |carbamate |- |CORRECT |ANSWER✔✔-diazinon, |dichlorovos, |malathion, |
parathion
Organochlorine |- |CORRECT |ANSWER✔✔-DDT, |lindane
Herbicides |- |CORRECT |ANSWER✔✔-2,4-D, |2,4,5-T, |Agent |Orange |(both |of |those |together), |
TCDD< |PCB |(Yusho |Oil |Disease)
Fungicides |- |CORRECT |ANSWER✔✔-Captan, |Griseofulvin
Thalidomide |fetal |abnormalities |- |CORRECT |ANSWER✔✔-phocomelia, |amelia, |radial |aplasia, |
polydactyly, |triphalangia, |atresia, |teratology |of |Fallot, |micro/anopthalmia, |kidney |defects, |ear |
defects, |no |CNS |defects
What |days |of |pregnancy |are |the |biggest |problem |- |CORRECT |ANSWER✔✔-27-40
Days |for |arm |suseptibility |- |CORRECT |ANSWER✔✔-27-30
Days |for |leg |susceptibility |- |CORRECT |ANSWER✔✔-30-33
Days |for |ear |susceptibility |- |CORRECT |ANSWER✔✔-21-27
, thalidomide |mechanisms |of |action |- |CORRECT |ANSWER✔✔-riboflavin |deficiency, |neuronal |
degeneration, |decreased |protein |synthesis
diethylstilbestrol |mechanisms |of |action |- |CORRECT |ANSWER✔✔-altered |cell |differentiation, |
estrogenization, |direct |carcinogen, |2-hit |carcinogen
psychiatric |drugs |- |CORRECT |ANSWER✔✔-lithium, |valium, |librium, |meprobamate
anticonvulsants |- |CORRECT |ANSWER✔✔-diphenylhydantoin, |valproic |acid
antibiotics |- |CORRECT |ANSWER✔✔-tetracyclines, |isoniazid
accutane |teratology |effects |- |CORRECT |ANSWER✔✔-ear |defects
microopthalmia
micrognathia
hydrocephalus
heart |defects
abortion
non-covalent |reaction |- |CORRECT |ANSWER✔✔-most |common/important |
reversible
covalent |reaction |- |CORRECT |ANSWER✔✔-irreversible |
aka |suicide |inhibition |or |mechanism |based |inhibition |
e.g., |epoxides, |grapefruit |juice, |what |happens |in |carcinogenesis
hydrogen |abstraction |reaction |- |CORRECT |ANSWER✔✔-HY |--> |XH |+ |Y.
Answers
Organophosphates, |carbamate |- |CORRECT |ANSWER✔✔-diazinon, |dichlorovos, |malathion, |
parathion
Organochlorine |- |CORRECT |ANSWER✔✔-DDT, |lindane
Herbicides |- |CORRECT |ANSWER✔✔-2,4-D, |2,4,5-T, |Agent |Orange |(both |of |those |together), |
TCDD< |PCB |(Yusho |Oil |Disease)
Fungicides |- |CORRECT |ANSWER✔✔-Captan, |Griseofulvin
Thalidomide |fetal |abnormalities |- |CORRECT |ANSWER✔✔-phocomelia, |amelia, |radial |aplasia, |
polydactyly, |triphalangia, |atresia, |teratology |of |Fallot, |micro/anopthalmia, |kidney |defects, |ear |
defects, |no |CNS |defects
What |days |of |pregnancy |are |the |biggest |problem |- |CORRECT |ANSWER✔✔-27-40
Days |for |arm |suseptibility |- |CORRECT |ANSWER✔✔-27-30
Days |for |leg |susceptibility |- |CORRECT |ANSWER✔✔-30-33
Days |for |ear |susceptibility |- |CORRECT |ANSWER✔✔-21-27
, thalidomide |mechanisms |of |action |- |CORRECT |ANSWER✔✔-riboflavin |deficiency, |neuronal |
degeneration, |decreased |protein |synthesis
diethylstilbestrol |mechanisms |of |action |- |CORRECT |ANSWER✔✔-altered |cell |differentiation, |
estrogenization, |direct |carcinogen, |2-hit |carcinogen
psychiatric |drugs |- |CORRECT |ANSWER✔✔-lithium, |valium, |librium, |meprobamate
anticonvulsants |- |CORRECT |ANSWER✔✔-diphenylhydantoin, |valproic |acid
antibiotics |- |CORRECT |ANSWER✔✔-tetracyclines, |isoniazid
accutane |teratology |effects |- |CORRECT |ANSWER✔✔-ear |defects
microopthalmia
micrognathia
hydrocephalus
heart |defects
abortion
non-covalent |reaction |- |CORRECT |ANSWER✔✔-most |common/important |
reversible
covalent |reaction |- |CORRECT |ANSWER✔✔-irreversible |
aka |suicide |inhibition |or |mechanism |based |inhibition |
e.g., |epoxides, |grapefruit |juice, |what |happens |in |carcinogenesis
hydrogen |abstraction |reaction |- |CORRECT |ANSWER✔✔-HY |--> |XH |+ |Y.
