NURS 660 EXAM 1 ANTIPSYCHOTIC
MEDICATIONS ELITE REVIEW FULLY
SOLVED EDITION 2026
⩥What is a major side effect of 1st generation antipsychotics?.
Answer:Galactorrhea and amenorrhea
⩥What causes Galactorrhea?. Answer:Dopamine 2 antagonism
⩥What lab should be checked when taking a 1st generation
antipsychotic?. Answer:Prolactin
⩥Why do typical antipsychotics raise prolactin?. Answer:They block
dopamine D2 receptors in the pituitary gland which typically prevents
prolactin secretion
⩥Which generation of antipsychotics are at a higher risk for NMS?.
Answer:1st generation
⩥What is NMS?. Answer:Characterized by muscle rigidity, altered
mental status and high fever
⩥Haloperidol MOA. Answer:High potency D2 receptor antagonist
,⩥Haloperidol indications. Answer:Acute agitation, Tourette's and
delirium
⩥Haloperidol side effects. Answer:EPS
TD
Galactorrhea
Amenorrhea
Prolonged QT with IV use
⩥Chlorpromazine (Thorazine) MOA. Answer:Low potency D2
antagonist
⩥Chlorpromazine indications. Answer:Acute psychosis
Hiccups
⩥Chlorpromazine side effects. Answer:ANTICHOLINERGIC!
Corneal deposits
Skin and eye color changes
⩥Perphenazine (Trilafon) indications. Answer:Schizophrenia
N/V
, ⩥Perphenazine drug interactions. Answer:CYP2D6
FDA recommends genetic testing
⩥2nd generation antipsychotics (atypical). Answer:Aripiprazole
(Abilify)
Brexpiprazole (Rexulti)
Clozapine (Clozaril)
Lurasidone (Latuda)
Lumateperone (Caplyta)
Olanzapine (Zyprexa)
Paliperidone (Invega)
Quetiapine (Seroquel)
Risperidone (Risperdal)
⩥2nd generation antipsychotic MOA. Answer:Work by antagonizing
5HT2A
⩥What are the most common side effects in 2nd generation
antipsychotics?. Answer:Weight gain
Increased triglycerides
Diabetes
MEDICATIONS ELITE REVIEW FULLY
SOLVED EDITION 2026
⩥What is a major side effect of 1st generation antipsychotics?.
Answer:Galactorrhea and amenorrhea
⩥What causes Galactorrhea?. Answer:Dopamine 2 antagonism
⩥What lab should be checked when taking a 1st generation
antipsychotic?. Answer:Prolactin
⩥Why do typical antipsychotics raise prolactin?. Answer:They block
dopamine D2 receptors in the pituitary gland which typically prevents
prolactin secretion
⩥Which generation of antipsychotics are at a higher risk for NMS?.
Answer:1st generation
⩥What is NMS?. Answer:Characterized by muscle rigidity, altered
mental status and high fever
⩥Haloperidol MOA. Answer:High potency D2 receptor antagonist
,⩥Haloperidol indications. Answer:Acute agitation, Tourette's and
delirium
⩥Haloperidol side effects. Answer:EPS
TD
Galactorrhea
Amenorrhea
Prolonged QT with IV use
⩥Chlorpromazine (Thorazine) MOA. Answer:Low potency D2
antagonist
⩥Chlorpromazine indications. Answer:Acute psychosis
Hiccups
⩥Chlorpromazine side effects. Answer:ANTICHOLINERGIC!
Corneal deposits
Skin and eye color changes
⩥Perphenazine (Trilafon) indications. Answer:Schizophrenia
N/V
, ⩥Perphenazine drug interactions. Answer:CYP2D6
FDA recommends genetic testing
⩥2nd generation antipsychotics (atypical). Answer:Aripiprazole
(Abilify)
Brexpiprazole (Rexulti)
Clozapine (Clozaril)
Lurasidone (Latuda)
Lumateperone (Caplyta)
Olanzapine (Zyprexa)
Paliperidone (Invega)
Quetiapine (Seroquel)
Risperidone (Risperdal)
⩥2nd generation antipsychotic MOA. Answer:Work by antagonizing
5HT2A
⩥What are the most common side effects in 2nd generation
antipsychotics?. Answer:Weight gain
Increased triglycerides
Diabetes
