NURS 660 EXAM 1 ANTIPSYCHOTIC
MEDICATIONS COMPREHENSIVE
EXAM REVIEW GUIDE WITH SOLVED
QUESTIONS
⩥ What is the treatment for akathisia? Answer:Beta blockers,
anticholinergics or lorazepam
⩥ What labs are monitored with clozapine? Answer:ANC, CBC, lipids,
glucose, weight
⩥ What is the main side effect of risperidone?
Answer:Hyperprolactinemia
⩥ What is the treatment when someone develops
hyperprolactinemia/galactorrhea from risperidone? Answer:Switch to
aripiprazole
⩥ Antagonism of which receptor site by atypical antipsychotics causes
weight gain? Answer:H1
⩥ Which antipsychotic causes the most weight gain?
Answer:Olanzepine
,⩥ What region of the brain is responsible for negative symptoms?
Answer:Mesocortical pathway
⩥ What is the function of the thalamus pathway? Answer:Sleep and
arousal
⩥ What is the function of the tuberoinfundibular pathway?
Answer:Controls prolactin release
⩥ How do you switch from Abilify to Zyprexa? Answer:Stop Abilify
immediately, taper Zyprexa up over two weeks
⩥ What symptoms occur when there is decreased dopamine in the
nigrostriatal pathway? Answer:EPS, TD, parkinsonism
⩥ What lab do you check before starting risperidone? Answer:Prolactin
⩥ What medication do you give for dystonia? Answer:Benztropine
⩥ What percentage of D2 occupancy is needed for atypical efficacy?
Answer:60%
, ⩥ What serotonin receptor is responsible for reducing EPS in atypical
antipsychotics? Answer:5HT2A
⩥ Which part of the brain is responsible for aggressive symptoms?
Answer:Orbitofrontal and amygdala
⩥ Are NMDA receptors hypo or hyper functioning in schizophrenia?
Answer:Hypo functioning
⩥ Schizophrenia DSM5 Answer:Delusions
Hallucination
Disorganized speech
Catatonic behavior
Negative symptoms
⩥ What symptoms originate from the dorsolateral prefrontal cortex?
Answer:Cognitive symptoms
⩥ What symptoms originate from the nucleus accumbens?
Answer:Negative stmptoms
⩥ What symptoms originate from the substantia ganglia? Answer:Motor
function and movement
MEDICATIONS COMPREHENSIVE
EXAM REVIEW GUIDE WITH SOLVED
QUESTIONS
⩥ What is the treatment for akathisia? Answer:Beta blockers,
anticholinergics or lorazepam
⩥ What labs are monitored with clozapine? Answer:ANC, CBC, lipids,
glucose, weight
⩥ What is the main side effect of risperidone?
Answer:Hyperprolactinemia
⩥ What is the treatment when someone develops
hyperprolactinemia/galactorrhea from risperidone? Answer:Switch to
aripiprazole
⩥ Antagonism of which receptor site by atypical antipsychotics causes
weight gain? Answer:H1
⩥ Which antipsychotic causes the most weight gain?
Answer:Olanzepine
,⩥ What region of the brain is responsible for negative symptoms?
Answer:Mesocortical pathway
⩥ What is the function of the thalamus pathway? Answer:Sleep and
arousal
⩥ What is the function of the tuberoinfundibular pathway?
Answer:Controls prolactin release
⩥ How do you switch from Abilify to Zyprexa? Answer:Stop Abilify
immediately, taper Zyprexa up over two weeks
⩥ What symptoms occur when there is decreased dopamine in the
nigrostriatal pathway? Answer:EPS, TD, parkinsonism
⩥ What lab do you check before starting risperidone? Answer:Prolactin
⩥ What medication do you give for dystonia? Answer:Benztropine
⩥ What percentage of D2 occupancy is needed for atypical efficacy?
Answer:60%
, ⩥ What serotonin receptor is responsible for reducing EPS in atypical
antipsychotics? Answer:5HT2A
⩥ Which part of the brain is responsible for aggressive symptoms?
Answer:Orbitofrontal and amygdala
⩥ Are NMDA receptors hypo or hyper functioning in schizophrenia?
Answer:Hypo functioning
⩥ Schizophrenia DSM5 Answer:Delusions
Hallucination
Disorganized speech
Catatonic behavior
Negative symptoms
⩥ What symptoms originate from the dorsolateral prefrontal cortex?
Answer:Cognitive symptoms
⩥ What symptoms originate from the nucleus accumbens?
Answer:Negative stmptoms
⩥ What symptoms originate from the substantia ganglia? Answer:Motor
function and movement
