LO1 ·
Define DMARDs
Disease
- Rheumatic drugs
modifying
Y ·
used for rheumatoid arthritis
used to control symptoms · used for other chronic inflammatory diseases
AND slow/stop progression of
the disease
What is rheumatoid arthritis ?
· chronic inflammatory conditions
· common cause of disability (1 in 100 people)
· Autoimmune >
- immune system attacks healthy cells in the
body - persistent inflammation (mainly joints) - joint damage
·
affected joints are swollen , painful , deformed and immobile
Treatment
·
NSAIDs and corticosteroids used mainly for symptom control/relive
· DMARD, - both symptom control and slow/stop progression of the disease
↳ this changed the life of patients and help treat the disease
classes of DMARDs
. Conventional
1 synthetic DMARDs : CSDMARDs
.
2 Biological DMARDS : bDMARDs
LO2 Discuss conventional synthetic DMARDs and give examples
Conventional synthetic DMARDS-CSDMARD,
methotrexate
small synthetic molecules
·
· most
commonly used : methotrexate
, methotrexate
&
stops it
Initially designed to inhibit the enzyme
dihydrofolate reductase
↓ Y
very
de important in
DNA and
involved in folate
RNA
tetrahydrofale
↓ Synthesis
metabolism
less DNA
RNA
synthesis
Cancer > as
-
a consequence inhibits cell proliferation and cell death
that's it
why was used in cancer
it can also inhibit enzyme AICAR
transformylase (ATIC)
antiinflammatory effect
nea
o
concentration inside the cell
which is then transported outside the cell- and activate
a GPCR called adenosine receptor
Y
activation of this will lead
Conventional DMARDs
to the activation
of adenosine
signalling pathways
Y this lower the
· small synthetic molecules
inflammation
· M O A is not
. .
fully understood like methotrexate so uses different strategies to target inflammation
non-specific mechanism of action
↓
* memorize 2SDMARD
the strategies
in the box
you don't need
to know the names
I
inhibit
Y cytokines
can affect
expression
other cells
non-specific
Define DMARDs
Disease
- Rheumatic drugs
modifying
Y ·
used for rheumatoid arthritis
used to control symptoms · used for other chronic inflammatory diseases
AND slow/stop progression of
the disease
What is rheumatoid arthritis ?
· chronic inflammatory conditions
· common cause of disability (1 in 100 people)
· Autoimmune >
- immune system attacks healthy cells in the
body - persistent inflammation (mainly joints) - joint damage
·
affected joints are swollen , painful , deformed and immobile
Treatment
·
NSAIDs and corticosteroids used mainly for symptom control/relive
· DMARD, - both symptom control and slow/stop progression of the disease
↳ this changed the life of patients and help treat the disease
classes of DMARDs
. Conventional
1 synthetic DMARDs : CSDMARDs
.
2 Biological DMARDS : bDMARDs
LO2 Discuss conventional synthetic DMARDs and give examples
Conventional synthetic DMARDS-CSDMARD,
methotrexate
small synthetic molecules
·
· most
commonly used : methotrexate
, methotrexate
&
stops it
Initially designed to inhibit the enzyme
dihydrofolate reductase
↓ Y
very
de important in
DNA and
involved in folate
RNA
tetrahydrofale
↓ Synthesis
metabolism
less DNA
RNA
synthesis
Cancer > as
-
a consequence inhibits cell proliferation and cell death
that's it
why was used in cancer
it can also inhibit enzyme AICAR
transformylase (ATIC)
antiinflammatory effect
nea
o
concentration inside the cell
which is then transported outside the cell- and activate
a GPCR called adenosine receptor
Y
activation of this will lead
Conventional DMARDs
to the activation
of adenosine
signalling pathways
Y this lower the
· small synthetic molecules
inflammation
· M O A is not
. .
fully understood like methotrexate so uses different strategies to target inflammation
non-specific mechanism of action
↓
* memorize 2SDMARD
the strategies
in the box
you don't need
to know the names
I
inhibit
Y cytokines
can affect
expression
other cells
non-specific
