NUR 301 EXAM 1 WEEK 1-3 (2025-2026)
QUESTIONS AND ANSWERS GRADED A+
What is an NSAID used for?
mild to moderate pain
What are the NSAIDs we must know?
diclofenac
aspirin
naproxen
ibuprofen
celecoxib
What is the different in mechanism of action between 1st generation and 2nd
generation NSAIDs?
1st generation: inhibits both COX-1 and COX-2
2nd generation: inhibits COX-2 only
General mechanism of action (MOA) for NSAIDs
- inhibits COX-1 and COX-2, which inhibits prostaglandin synthesis centrally and
peripherally
,- antipyretic
- anti-inflammatory
- antihistamine
General side effects of NSAIDs
- GI upset/bleeding
- Renal Toxicity
- Liver Effects (jaundice or hepatitis)
- Hypertension/CVA/MI
- Setven's Johnson Syndrome
- Seizures
- Headache
- Nervousness
General nursing considerations for NSAIDs
- take with food (specifically protein rich in order to coat)
- caution with cardiac patients or patients with high BP
- caution for patients with bleeding risk (ex: if taking warfarin)
- monitor pain level
- do not crush, may give liquid
Additional MOA for aspirin
,- Decrease platelet aggregation
Additional side effects (SE) for aspirin
A - abdominal pain & asthma trigger
S - salicylism
P - Peptic ulcer disease
I - Intestinal bleeding
R - Reye's Syndrome & respiratory distress (Laryngeal edema)
I - Itchy/rash
N - noise (tinnitus)
Additional desired outcome for aspirin
Reduced clotting risk
What kind of route of administration is diclofenac given?
Topical - ex: Voltaren gel
- will be more localized so wont have the same side effects as other NSAIDs
Additional SE for diclofenac
- pruritus
- dry skin
, Additional nursing consideration for diclofenac
- Monitor skin integrity
Specific use for diclofenac
Knee and back pain
What is the 2nd generation NSAID we must know?
celecoxib (Celebrex)
What is celecoxib's MOA?
inhibits COX-2
Additional SE for celecoxib
- lower GI risk (better for long-term use)
- greater risk for MI
What is an example of a non-opioid analgesic?
acetaminophen (Tylenol)
QUESTIONS AND ANSWERS GRADED A+
What is an NSAID used for?
mild to moderate pain
What are the NSAIDs we must know?
diclofenac
aspirin
naproxen
ibuprofen
celecoxib
What is the different in mechanism of action between 1st generation and 2nd
generation NSAIDs?
1st generation: inhibits both COX-1 and COX-2
2nd generation: inhibits COX-2 only
General mechanism of action (MOA) for NSAIDs
- inhibits COX-1 and COX-2, which inhibits prostaglandin synthesis centrally and
peripherally
,- antipyretic
- anti-inflammatory
- antihistamine
General side effects of NSAIDs
- GI upset/bleeding
- Renal Toxicity
- Liver Effects (jaundice or hepatitis)
- Hypertension/CVA/MI
- Setven's Johnson Syndrome
- Seizures
- Headache
- Nervousness
General nursing considerations for NSAIDs
- take with food (specifically protein rich in order to coat)
- caution with cardiac patients or patients with high BP
- caution for patients with bleeding risk (ex: if taking warfarin)
- monitor pain level
- do not crush, may give liquid
Additional MOA for aspirin
,- Decrease platelet aggregation
Additional side effects (SE) for aspirin
A - abdominal pain & asthma trigger
S - salicylism
P - Peptic ulcer disease
I - Intestinal bleeding
R - Reye's Syndrome & respiratory distress (Laryngeal edema)
I - Itchy/rash
N - noise (tinnitus)
Additional desired outcome for aspirin
Reduced clotting risk
What kind of route of administration is diclofenac given?
Topical - ex: Voltaren gel
- will be more localized so wont have the same side effects as other NSAIDs
Additional SE for diclofenac
- pruritus
- dry skin
, Additional nursing consideration for diclofenac
- Monitor skin integrity
Specific use for diclofenac
Knee and back pain
What is the 2nd generation NSAID we must know?
celecoxib (Celebrex)
What is celecoxib's MOA?
inhibits COX-2
Additional SE for celecoxib
- lower GI risk (better for long-term use)
- greater risk for MI
What is an example of a non-opioid analgesic?
acetaminophen (Tylenol)
