NR 565 Week 1 Quiz Questions And Answers
Latest Update 2026
NR 565: Advanced Pharmacology Fundamentals - Practice Questions
1. When considering pharmacokinetics, which factor is most likely to cause
significant variability in drug serum levels among older adult patients?
A) Receptor sensitivity
B) Hepatic first-pass effect
C) Renal function and glomerular filtration rate (GFR)
,D) Protein binding competition
Correct Answer : C
2. A patient with a history of sustained ventricular tachycardia is prescribed
amiodarone. The provider should prioritize monitoring for which potentially
life-threatening adverse effect?
A) Pulmonary fibrosis
B) Hypothyroidism
C) Blue-grey skin discoloration
D) Corneal microdeposits
Correct Answer : A
3. Which class of antibiotics is associated with the "disulfiram-like reaction"
causing nausea and flushing when combined with alcohol?
A) Macrolides (e.g., azithromycin)
B) Cephalosporins (e.g., cefotetan)
C) Fluoroquinolones (e.g., ciprofloxacin)
D) Tetracyclines (e.g., doxycycline)
Correct Answer : B
4. What is the first-line recommended pharmacologic treatment for generalized
anxiety disorder (GAD) according to current guidelines?
A) Benzodiazepines (e.g., lorazepam)
B) Tricyclic antidepressants (e.g., amitriptyline)
C) SSRIs or SNRIs (e.g., sertraline, venlafaxine)
D) Antipsychotics (e.g., quetiapine)
Correct Answer : C
5. For a patient with Type 2 Diabetes Mellitus and established atherosclerotic
cardiovascular disease (ASCVD), which class of glucose-lowering medication has
proven cardiovascular mortality benefit and is recommended?
A) Sulfonylureas
B) SGLT2 Inhibitors (e.g., empagliflozin)
C) DPP-4 Inhibitors (e.g., sitagliptin)
D) Meglitinides
Correct Answer : B
, 6. Which antimicrobial prescribing principle is critical for combating resistance?
A) Always use broad-spectrum antibiotics first.
B) Use the newest antibiotic available.
C) Target the therapy to the most likely pathogen(s).
D) Extend therapy duration to ensure complete eradication.
Correct Answer : C
7. The major pharmacodynamic concern when prescribing warfarin with
sulfamethoxazole/trimethoprim is:
A) Reduced warfarin absorption.
B) Induction of warfarin metabolism.
C) Displacement from protein binding sites, increasing free warfarin.
D) Additive effects on platelet inhibition.
Correct Answer : C
8. A patient taking clopidogrel for coronary stent prevention should avoid
concurrent use of which medication due to a potent drug-drug interaction?
A) Omeprazole
B) Famotidine
C) Calcium carbonate
D) Metformin
Correct Answer : A
NR565 Week 8 Final Exam - Simulation (Questions 1-40)
1. A 65-year-old male with a history of hypertension and osteoarthritis is started
on celecoxib (Celebrex) for pain. The NP understands that this medication's
cardiovascular risk profile, compared to non-selective NSAIDs like ibuprofen, is
best described as:
A. Having no cardiovascular risk.
B. Having a lower gastrointestinal risk but a similar potential for increasing major
adverse cardiac events (MACE).
C. Having a higher cardiovascular risk due to COX-2 selectivity.
D. Having both lower GI and lower cardiovascular risk.
*Rationale: Celecoxib is a selective COX-2 inhibitor. It offers a lower risk of GI
bleeding compared to non-selective NSAIDs, but does not eliminate the
cardiovascular risk. The PRECISION trial showed it was non-inferior to
Latest Update 2026
NR 565: Advanced Pharmacology Fundamentals - Practice Questions
1. When considering pharmacokinetics, which factor is most likely to cause
significant variability in drug serum levels among older adult patients?
A) Receptor sensitivity
B) Hepatic first-pass effect
C) Renal function and glomerular filtration rate (GFR)
,D) Protein binding competition
Correct Answer : C
2. A patient with a history of sustained ventricular tachycardia is prescribed
amiodarone. The provider should prioritize monitoring for which potentially
life-threatening adverse effect?
A) Pulmonary fibrosis
B) Hypothyroidism
C) Blue-grey skin discoloration
D) Corneal microdeposits
Correct Answer : A
3. Which class of antibiotics is associated with the "disulfiram-like reaction"
causing nausea and flushing when combined with alcohol?
A) Macrolides (e.g., azithromycin)
B) Cephalosporins (e.g., cefotetan)
C) Fluoroquinolones (e.g., ciprofloxacin)
D) Tetracyclines (e.g., doxycycline)
Correct Answer : B
4. What is the first-line recommended pharmacologic treatment for generalized
anxiety disorder (GAD) according to current guidelines?
A) Benzodiazepines (e.g., lorazepam)
B) Tricyclic antidepressants (e.g., amitriptyline)
C) SSRIs or SNRIs (e.g., sertraline, venlafaxine)
D) Antipsychotics (e.g., quetiapine)
Correct Answer : C
5. For a patient with Type 2 Diabetes Mellitus and established atherosclerotic
cardiovascular disease (ASCVD), which class of glucose-lowering medication has
proven cardiovascular mortality benefit and is recommended?
A) Sulfonylureas
B) SGLT2 Inhibitors (e.g., empagliflozin)
C) DPP-4 Inhibitors (e.g., sitagliptin)
D) Meglitinides
Correct Answer : B
, 6. Which antimicrobial prescribing principle is critical for combating resistance?
A) Always use broad-spectrum antibiotics first.
B) Use the newest antibiotic available.
C) Target the therapy to the most likely pathogen(s).
D) Extend therapy duration to ensure complete eradication.
Correct Answer : C
7. The major pharmacodynamic concern when prescribing warfarin with
sulfamethoxazole/trimethoprim is:
A) Reduced warfarin absorption.
B) Induction of warfarin metabolism.
C) Displacement from protein binding sites, increasing free warfarin.
D) Additive effects on platelet inhibition.
Correct Answer : C
8. A patient taking clopidogrel for coronary stent prevention should avoid
concurrent use of which medication due to a potent drug-drug interaction?
A) Omeprazole
B) Famotidine
C) Calcium carbonate
D) Metformin
Correct Answer : A
NR565 Week 8 Final Exam - Simulation (Questions 1-40)
1. A 65-year-old male with a history of hypertension and osteoarthritis is started
on celecoxib (Celebrex) for pain. The NP understands that this medication's
cardiovascular risk profile, compared to non-selective NSAIDs like ibuprofen, is
best described as:
A. Having no cardiovascular risk.
B. Having a lower gastrointestinal risk but a similar potential for increasing major
adverse cardiac events (MACE).
C. Having a higher cardiovascular risk due to COX-2 selectivity.
D. Having both lower GI and lower cardiovascular risk.
*Rationale: Celecoxib is a selective COX-2 inhibitor. It offers a lower risk of GI
bleeding compared to non-selective NSAIDs, but does not eliminate the
cardiovascular risk. The PRECISION trial showed it was non-inferior to
