ATI MED SURG IMMUNE & INFECTION, ATI MED SURG
ONCOLOGY, ATI MED SURG CARDIOVASCULAR NEWEST
2025/2026 ACTUAL EXAM COMPLETE 200+ QUESTIONS AND
CORRECT DETAILED ANSWERS (VERIFIED ANSWERS)
|ALREADY GRADED A+||BRAND NEW!!
### ATI Med-Surg Practice Set 1: Immune & Infectious Diseases (Most Tested & Difficult Topics)
This set includes **20 challenging questions** focusing on high-yield ATI areas: HIV/AIDS,
sepsis/SIRS, autoimmune disorders (lupus, rheumatoid arthritis), transplant rejection, infection
control, and antimicrobial resistance. Questions emphasize priority actions, complications,
teaching, and pharmacology.
1. A client with HIV has a CD4+ count of 150 cells/mm³ and develops thrush. Which
antiretroviral medication adjustment is priority?
A. Initiate zidovudine (AZT) monotherapy
B. Start highly active antiretroviral therapy (HAART) if not already on it
C. Discontinue all medications due to resistance
D. Add ritonavir only
**Answer-: B**
**Explanation**: CD4+ <200 indicates severe immunosuppression; opportunistic infections
like thrush require HAART initiation or optimization for viral suppression (ATI priority: immune
reconstitution).
,2. A client in septic shock has BP 80/50 mmHg, lactate 5 mmol/L, and urine output 15 mL/hr.
Which intervention is priority per Surviving Sepsis guidelines?
A. Administer broad-spectrum antibiotics after cultures
B. Initiate fluid resuscitation with 30 mL/kg crystalloids
C. Start low-dose corticosteroids
D. Apply vasopressors immediately
**Answer-: B**
**Explanation**: Early goal-directed therapy prioritizes rapid fluid bolus within first hour to
restore perfusion before vasopressors/antibiotics.
3. A client with systemic lupus erythematosus (SLE) reports joint pain, fatigue, and new malar
rash. Labs: ANA positive, anti-dsDNA elevated. Priority nursing action?
A. Teach sun avoidance and sunscreen use
B. Administer high-dose opioids for pain
C. Prepare for immediate dialysis
D. Restrict all physical activity
**Answer-: A**
**Explanation**: Photosensitivity exacerbates SLE flares; client teaching prevents triggers
(most tested immune topic).
4. Select all that apply (SATA): Manifestations of anaphylactic shock.
A. Bronchospasm
B. Stridor
C. Bradycardia
D. Urticaria
E. Hypertension
, **Answer-: A, B, D**
**Explanation**: Type I hypersensitivity causes wheezing, laryngeal edema, hives;
tachycardia and hypotension are cardiovascular signs.
5. A posttransplant client on immunosuppressants develops fever, graft tenderness. Priority
concern?
A. Acute rejection
B. Chronic rejection
C. Infection
D. Medication nonadherence
**Answer-: C**
**Explanation**: Immunosuppression increases infection risk first; rejection presents
differently (ATI emphasizes infection vigilance).
6. Client with MRSA in wound. Appropriate isolation precaution?
A. Droplet
B. Airborne
C. Contact
D. Standard only
**Answer-: C**
**Explanation**: Contact precautions for multidrug-resistant organisms.
7. Client with rheumatoid arthritis on methotrexate develops oral ulcers and fatigue. Priority
lab to monitor?
A. CBC for bone marrow suppression
, B. Serum creatinine
C. Liver enzymes only
D. Rheumatoid factor
**Answer-: A**
**Explanation**: Methotrexate toxicity causes pancytopenia; stomatitis is early sign.
8. HIV client asks about safe sex. Best teaching?
A. Condoms not needed if undetectable viral load
B. Use latex condoms consistently
C. Oral sex is always safe
D. Abstinence only
**Answer-: B**
**Explanation**: Consistent condom use prevents transmission even with U=U
(undetectable=untransmittable), but not 100%.
9. Early sign of sepsis in older adult?
A. Hypotension
B. Altered mental status
C. Fever >101°F
D. Oliguria
**Answer-: B**
**Explanation**: Atypical presentation in elderly; confusion often first.
10. Client with neutropenia (ANC <500) post-chemo. Priority intervention?
ONCOLOGY, ATI MED SURG CARDIOVASCULAR NEWEST
2025/2026 ACTUAL EXAM COMPLETE 200+ QUESTIONS AND
CORRECT DETAILED ANSWERS (VERIFIED ANSWERS)
|ALREADY GRADED A+||BRAND NEW!!
### ATI Med-Surg Practice Set 1: Immune & Infectious Diseases (Most Tested & Difficult Topics)
This set includes **20 challenging questions** focusing on high-yield ATI areas: HIV/AIDS,
sepsis/SIRS, autoimmune disorders (lupus, rheumatoid arthritis), transplant rejection, infection
control, and antimicrobial resistance. Questions emphasize priority actions, complications,
teaching, and pharmacology.
1. A client with HIV has a CD4+ count of 150 cells/mm³ and develops thrush. Which
antiretroviral medication adjustment is priority?
A. Initiate zidovudine (AZT) monotherapy
B. Start highly active antiretroviral therapy (HAART) if not already on it
C. Discontinue all medications due to resistance
D. Add ritonavir only
**Answer-: B**
**Explanation**: CD4+ <200 indicates severe immunosuppression; opportunistic infections
like thrush require HAART initiation or optimization for viral suppression (ATI priority: immune
reconstitution).
,2. A client in septic shock has BP 80/50 mmHg, lactate 5 mmol/L, and urine output 15 mL/hr.
Which intervention is priority per Surviving Sepsis guidelines?
A. Administer broad-spectrum antibiotics after cultures
B. Initiate fluid resuscitation with 30 mL/kg crystalloids
C. Start low-dose corticosteroids
D. Apply vasopressors immediately
**Answer-: B**
**Explanation**: Early goal-directed therapy prioritizes rapid fluid bolus within first hour to
restore perfusion before vasopressors/antibiotics.
3. A client with systemic lupus erythematosus (SLE) reports joint pain, fatigue, and new malar
rash. Labs: ANA positive, anti-dsDNA elevated. Priority nursing action?
A. Teach sun avoidance and sunscreen use
B. Administer high-dose opioids for pain
C. Prepare for immediate dialysis
D. Restrict all physical activity
**Answer-: A**
**Explanation**: Photosensitivity exacerbates SLE flares; client teaching prevents triggers
(most tested immune topic).
4. Select all that apply (SATA): Manifestations of anaphylactic shock.
A. Bronchospasm
B. Stridor
C. Bradycardia
D. Urticaria
E. Hypertension
, **Answer-: A, B, D**
**Explanation**: Type I hypersensitivity causes wheezing, laryngeal edema, hives;
tachycardia and hypotension are cardiovascular signs.
5. A posttransplant client on immunosuppressants develops fever, graft tenderness. Priority
concern?
A. Acute rejection
B. Chronic rejection
C. Infection
D. Medication nonadherence
**Answer-: C**
**Explanation**: Immunosuppression increases infection risk first; rejection presents
differently (ATI emphasizes infection vigilance).
6. Client with MRSA in wound. Appropriate isolation precaution?
A. Droplet
B. Airborne
C. Contact
D. Standard only
**Answer-: C**
**Explanation**: Contact precautions for multidrug-resistant organisms.
7. Client with rheumatoid arthritis on methotrexate develops oral ulcers and fatigue. Priority
lab to monitor?
A. CBC for bone marrow suppression
, B. Serum creatinine
C. Liver enzymes only
D. Rheumatoid factor
**Answer-: A**
**Explanation**: Methotrexate toxicity causes pancytopenia; stomatitis is early sign.
8. HIV client asks about safe sex. Best teaching?
A. Condoms not needed if undetectable viral load
B. Use latex condoms consistently
C. Oral sex is always safe
D. Abstinence only
**Answer-: B**
**Explanation**: Consistent condom use prevents transmission even with U=U
(undetectable=untransmittable), but not 100%.
9. Early sign of sepsis in older adult?
A. Hypotension
B. Altered mental status
C. Fever >101°F
D. Oliguria
**Answer-: B**
**Explanation**: Atypical presentation in elderly; confusion often first.
10. Client with neutropenia (ANC <500) post-chemo. Priority intervention?
