Medical-Surgical Nursing MCQ Study Guide & Practice Test Bank

Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank




Covered

PART 1: Foundations of Clinical Medicine

PART 2: Cardinal Symptoms & Clinical Presentations

PART 3: Clinical Pharmacology

PART 4: Oncology & Hematology

PART 5: Infectious Diseases

PART 6: Cardiovascular Disorders

PART 7: Respiratory Disorders

PART 8: Critical Care Medicine

PART 9: Kidney & Urinary Tract Disorders

PART 10: Gastrointestinal & Hepatobiliary Disorders

,PART 11: Immune-Mediated & Rheumatologic Disorders

PART 12: Endocrinology & Metabolism

PART 13: Neurologic & Psychiatric Disorders

PART 14: Toxicology & Environmental Injury

PART 15: Environmental & Occupational Medicine

PART 16: Genetics, Precision & Systems Medicine

PART 17–20: Special & Emerging Topics




Harrison’s Principles of Internal Medicine, 22nd ed.
Chapters 1–13 | Integrated Test Bank (20 MCQs Total)


1. Which principle best defines evidence-based medical
practice?
A. Reliance on expert opinion
B. Use of randomized trials only
C. Integration of best evidence with clinical expertise and
patient values
D. Application of population data to all patients
Correct Answer: C
Rationale: Harrison’s emphasizes evidence-based medicine as
the integration of high-quality research evidence, clinician

,expertise, and patient preferences—not evidence alone.
Citation: Harrison’s 22nd ed., Ch. 1 – The Practice of Medicine


2. The strongest predictor of preventable morbidity in modern
health systems is:
A. Genetic predisposition
B. Limited diagnostic technology
C. Behavioral and social determinants of health
D. Physician knowledge deficits
Correct Answer: C
Rationale: Harrison’s highlights social, economic, and
behavioral determinants as major contributors to preventable
disease burden.
Citation: Harrison’s 22nd ed., Ch. 2 – Promoting Good Health


3. Vaccine hesitancy is most accurately described as:
A. Complete refusal of all vaccines
B. A result of misinformation alone
C. A spectrum of attitudes ranging from delay to refusal
D. A legally defined medical objection
Correct Answer: C
Rationale: Harrison’s defines vaccine hesitancy as a continuum,
influenced by trust, risk perception, and sociocultural factors.

, Citation: Harrison’s 22nd ed., Ch. 3 – Vaccine Opposition and
Hesitancy


4. A nurse supporting shared decision-making should prioritize
which action?
A. Presenting the clinician’s preferred option
B. Avoiding discussion of uncertainty
C. Eliciting patient goals and values
D. Limiting patient involvement to consent
Correct Answer: C
Rationale: Shared decision-making centers on patient values,
particularly when multiple reasonable options exist.
Citation: Harrison’s 22nd ed., Ch. 4 – Decision-Making in Clinical
Medicine


5. Precision medicine primarily seeks to:
A. Replace population-based guidelines
B. Use genomic and molecular data to individualize care
C. Eliminate environmental health factors
D. Standardize treatment across populations
Correct Answer: B
Rationale: Precision medicine integrates genetic, molecular, and
environmental data to tailor prevention and treatment
strategies.