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NSG530 / NSG 530 Exam 1 (Latest 2024 / 2025): Advanced Pathophysiology | Questions and Verified Answers | 100% Correct | Grade A - Wilkes $10.49
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NSG530 / NSG 530 Exam 1 (Latest 2024 / 2025): Advanced Pathophysiology | Questions and Verified Answers | 100% Correct | Grade A - Wilkes

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Exam 1: NSG530 / NSG 530 (Latest 2024 / 2025) - Advanced Pathophysiology Exam | Questions and Verified Answers | 100% Correct | Grade A - Wilkes Q: When antibodies are formed against red blood cell antigens of the Rh system, how are the blood cells destroyed? a. Complement-mediated cell lysis b. Ph...

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NSG 530 - Advanced Pathophysiology


Exam 1



Question:
When antibodies are formed against red blood cell antigens of the Rh
system, how are the blood cells destroyed?
a. Complement-mediated cell lysis
b. Phagocytosis by macrophages
c. Phagocytosis in the spleen
d. Neutrophil granules and toxic oxygen products
ANSWER: C
Antibodies against platelet-specific antigens or against red blood cell
antigens of the Rh system coat those cells at low density, resulting in their
preferential removal by phagocytosis in the spleen, rather than by
complement-mediated lysis. These blood cells are not destroyed by
complement-mediated cell lysis, phagocytosis by macrophages, neutrophil
granules, or toxic oxygen products.




Question:
When soluble antigens from infectious agents enter circulation, what is
tissue damage a result of?
a. Complement-mediated cell lysis

,b. Phagocytosis by macrophages
c. Phagocytosis in the spleen
d. Neutrophil granules and toxic oxygen products
ANSWER: D
Of the options available, only the components of neutrophil granules as well
as the several toxic oxygen products produced by these cells, damage the
tissue.


Question:
How are target cells destroyed in a type II hypersensitivity reaction?
a. Complement-mediated cell lysis
b. Phagocytosis by macrophages
c. Neutrophil granules and toxic oxygen products
d. Natural killer cells
ANSWER: D




The mechanism that results in a type II hypersensitivity reaction involves a
subpopulation of cytotoxic cells that are not antigen specific (natural killer
[NK] cells). Antibody on the target cell is recognized by Fc receptors on the
NK cells, which releases toxic substances that destroy the target cell. The
other options do not cause the destruction of target cells related to a type II
hypersensitivity reaction.

,Question:
Graves’ disease (hyperthyroidism) is an example of which type II
hypersensitivity reaction?
a. Modulation
b. Antibody-dependent cell-mediated cytotoxicity
c. Neutrophil-mediated damage
d. Complement-mediated lysis
ANSWER: A
The antibody reacts with the receptors on the target cell surface and
modulates the function of the receptor by preventing interactions with their
normal ligands, replacing the ligand and inappropriately stimulating the
receptor or destroying the receptor. For example, in the hyperthyroidism
(excessive thyroid activity) of Graves disease, autoantibody binds to and
activates receptors for thyroid-stimulating hormone (TSH) (a pituitary
hormone that controls the production of the hormone thyroxine by the
thyroid). Graves disease is not a result of cell-mediated cytotoxicity,
neutrophil-mediated damage, or complement-mediated lysis.




Question:
Type III hypersensitivity reactions are a result of which of these?
a. Antibodies coating mast cells by binding to receptors that signal its
degranulation, followed by the discharge of preformed mediators
b. Antibodies binding to soluble antigens that were released into body fluids
and the immune complexes being deposited in the tissues
c. Tc cells or lymphokine-producing Th1 cells directly attacking and
destroying cellular targets
d. Antibodies binding to the antigen on the cell surface

, ANSWER: B
Antigen-antibody (immune) complexes that are formed in the circulation
and then deposited later in vessel walls or extravascular tissues cause most
type III hypersensitivity diseases. Type III hypersensitivity reactions are not
the result of antibodies coating mast cells to signal their degranulation,
immune cells directly attacking and destroying targets, or antibodies binding
to the antigen on the cell surface.




Question:
A type IV hypersensitivity reaction causes which result?
a. Antibodies coating mast cells by binding to receptors that signal its
degranulation, followed by the discharge of preformed mediators
b. Antibodies binding to soluble antigens that were released into body fluids
and the immune complexes being deposited in the tissues
c. Lymphokine-producing Th1 cells directly attacking and destroying cellular
targets
d. Antibodies binding to the antigen on the cell surface
ANSWER: C
Type I, II, and III hypersensitivity reactions are mediated by antibody, type
IV reactions are mediated by T lymphocytes and do not involve antibody.
Type IV mechanisms occur through either Tc cells or lymphokine-producing
Th1 cells. Tc cells directly attack and destroy cellular targets.

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