Benzyne Study guides, Class notes & Summaries

CHEM 2302 Exam 2 Questions & Answers 2023/2024 nucleophilic aromatic substitution by addition-elimination - ANSWER-aryl halides with electron-withdrawing groups (NO₂) in ortho or para position can react with nucleophiles to substitute a leaving group for nucleophile resonance stabilized anion intermediate rate increases with more electron-withdrawing roups or more electronegative halogen nucleophilic aromatic substitution by elimination-addition - ANSWER-aryl halides without an electro...

Organic Chemistry 202 Synthetic Transformations, Top Exam Questions & answers, Rated A+ reduction of an aldehyde or ketone to an alcohol LiAlH4 or NaBH4 H3O H2O lithium dialkyl cuprate reagent from an alkyl halide 4 Li metal CuI reduction of a nitro group to an amine Zn(Hg) HCl reduction of a benzyl carbonyl H2/Pd or Zn(Hg) HCl NAS (normal condition must be 1 EWG ortho/para to leaving group) nucleophile (–OH, –OR, R3N) benzyne reactions 1) NaOH 2) dilute acid benzyne...

CHEM 1315 Practice Exam Question Set 1 1. (3 points each) Draw the Lewis structure of the following species with proper assignment of formal charge(s). If any of them have resonance structure(s), give all the possible reasonable structures. (a) HNO3 (b) [B(OH)4]– (c) N – (d) O3 2. (6 points each) Most of these are more difficult than you will find on the exam. But if you can answer them, you’re in good shape for these topics. Draw the indicated orbital and answer the que...

Lecture 5 of the Aromatic and Heteroaromatic course at Durham University, hand-written, neat diagrams

3) A major step in “proving” the “benzyne mechanism” was shown in 1953 by John D. Roberts in which isotopically-labeled chlorobenzene was exposed to potassium amide to give a mixture of labelled aniline products (for the full article, see DOI: 10.1021/ja01109a523, or there is an excerpt in Vollhardt-Schore in section 22-4). The product distribution showed that there are two different carbon-14 labelled centers in the product. Provide a mechanism for this transformation, taking care to sh...