Self-tolerance and immunoregulation: mechanisms of self-tolerance, mechanisms of autoimmunity and role of genetic factor e.g. MCH in autoimmunity. Transplantation: mechanisms of graft rejection, grafting privilege sites, organ and bone marrow transplant, Immunological diseases: autoimmunity, inflammation, principles of therapy for immune-mediated diseases: anti-inflammatory agents, antagonists against proinflammatory cytokines such as TNF and IL-1, immunosuppressive drugs e.g. cyclosporine A, Vaccines and vaccination, Immunotherapy: application of monoclonal antibodies technology, Tumor: immunodiagnosis, and radiotherapy. Gene therapy, Biosensors, DNA probes, Drug delivery: liposomes and DNA delivery vectors for somatic cell.