MOLECULAR REGULATION OF HEALTH AND DISEASE (HAP31806)

Reader lecture notes

This is a summary of the course reader Molecular Regulation Of Health And Disease. All the five themes of this course are summarised, namely: molecular regulation of energy and nutriënt metabolism, microbiota in health and disease, intestinal homeostasis in health and disease, toxicology: epigenetics and endothelial function.

Chapter 5. Endothelial Function 5.1. Introduction 5.2. Endothelial dysfunction 5.3. Atherosclerosis

Chapter 4. Toxiology: Epigenetics 4.1. Epigenetics: An Introduction 4.2. Epigenetics: Mechanisms and Molecular Basis 4.3. Epigenetics in Development 4.4. Cancee Epigenetics

Chapter 3. Intestinal Homeostasis in Health and Disease 3.1. Intestinal Homeostasis - A delicate balancing act 3.2. Basic Anatomy of the Human Gastrointestinal Tract 3.3. The Epithelial Barrier 3.4. Secreted and Membrane Bound Mucins Keep Microbes at a Distance 3.5. Antimicrobial Peptides and Proteins 3.6. Innate Regulation of Mammalian Innate Defense 3.7. Pattern Recognition Receptors and Inflammatory Signaling 3.8. Regulation of Innate Receptor Recognition and Signaling 3.9. Inflammatory Bowe...

Chapter 2. Microbiota in Health and Disease 2.1. Gastrointestinal microbes 2.2. Microbial components influencing host physiology

Chapter 1. Molecular Regulation of Energy and Nutrient Metabolism 1.1. Introduction 1.2. Mitochondria 1.3. Reprogramming of Metabolism 1.4. Regulation of Cellular Metabolic Activity 1.5. Anti Cancer Strategies Targeting Metabolism