MIC 205 exam 3 Daydif ASU/ Arizona State University-
Downtown Phoenix/ Mic 205 Exam 3 Daydiff/ 2 SETS
COMPILED WITH COMPLETE SOLUTION GUARANTEED
SUCCESS NEW EDITION 100% VERIFIED CORRECT
Prion Characteris cs - Ans single protein, two stable ter ary structures, mammals contain
gene, excess PrP produc on or muta ons in Prp gene, cause newly synthesized cellular form to
refold into prion form
Prion diseases - Ans only destroyed by incinera on
Drugs - Ans are used to control the growth of microorganisms in the body/ chemicals that
affect physiology
Controlling microbial growth in the body - Ans incinera on, UV rays from sunlight, Pressure
Chemotherapeu c Agents - Ans drugs that act against diseases; an microbials designed to
treat infec ons
Drug examples - Ans Penicillin (an bacterial); tylenol (pain med); insulin (sugar control); birth
control pills; zanax; viagra; caffiene; THC/Acid
Paul Ehrlich - Ans Salvarsan (arsphenamine) 1910- first modern chemotherapeu c agent;
arsenic compound used to treat syphilis
,Alexander Fleming - Ans Penicillin 1929- not available rou nely un l late 1940's; produced by
penicillium mold
Gerhard Domagk - Ans Sulfanilamide 1932- first widely available and prac cal an microbial
agent; inhibits metabolic synthesis of DNA and RNA nucleo des
Selec ve toxicity - Ans key factor for an microbial ac on in the body; kill the pathogen but not
the host
Inhibi on of cell wall synthesis - Ans prevent cross-linkage of NAM in newly synthesized
bacterial cell walls; no effect on exis ng pep doglycan; growing cells; no effect on plant/animal
cells
Beta lactams - Ans most prominent in this group; func onal of molecules are beta lactam rings
beta lactam rings - Ans binds to enzymes that cross link NAM subunits; cause bacteria to have
weakened cell walls and eventually lyse
Semisynthe c deriva ves of beta-lactams - Ans more stable in acidic environments; more
readily absorbed; less suscep ble to deac va on; more ac ve against more types of bacteria
Inhibi on of Protein synthesis - Ans prokaryo c ribosomes are 70s; selec vely targe ng and
inhibi ng transla on
Protein synthesis examples - Ans streptomycin; tetracyclines; erythromycin;
Disrup on of cytoplasmic membranes - Ans incorporated into the cytoplasmic membrane and
damage its integrity
,Amphotericin B - Ans a=aches to ergosterol found in fungal membranes- an fungal agent
Sulfa drugs - Ans inhibit metabolic pathways used for biosynthesis of DNA and RNA
nulceo des
Broad spectrum drugs - Ans may allow for secondary or superinfec ons to develop (killing of
normal flora reduces microbial antagonism)
External Infec ons: - Ans topical(local)- direct applica on of creams and pastes to the skin
Internal Infec ons: - Ans Oral-simple, but pa ents struggle following direc ons
Intramuscular- direct injec on into muscle ssue
Intravenous- direct administra on into blood stream via needle/catheter; achieves highest
levels of drug in body in shortest amount of me
Toxicity - Ans kidneys, liver, nerves
Tetracylcine - Ans froms calcium complexes that damage teeth and bones
allergies - Ans rare, but can be life threatening
Disrup on of normal flora - Ans yeast infec ons: overgrowth of Candida albicans in the vagina
or mouth
Pseudomembranous coli s: overgrowth of Clastridium difficile in colon due to clindamycin and
cepahlosporin an bio cs
, Development of Resistant Organisms - Ans bacteria acquire drug resistance in two way;
spontaneous muta ons of chromosomal genes/ acquisi on of an bio c resistance plasmids via
transforma on, transduc on, and conjuga on
Bacterial Resistance Mechanisms - Ans produc on of an enzyme that inac vates or destroys
an an bio c, ability to produce beta lactamase enzyme, preven on of drug entry, altera on of
the drugs receptor, altera on of the cells metabolic chemistry, proteins that pump drugs out of
the cell
High concentra on of drug maintained in pa ent for long enough me to kill all sensi ve cells
and inhibit others long enough for the immune system to destroy them - Ans Methods for
retarding resistance
Use an microbial agents in combina on(synergism) - Ans methods for retarding resistance
limit use of an microbials to necessary cases - Ans methods for retarding resistance
development of new varia ons - Ans methods for retarding resistance
Transient Microbiota - Ans remain in the body for only hours to months before disappearing;
cannot persist in the body due to compe on, body defenses, chemical/physical changes
Opportunis c Pathogens - Ans normal flora that can cause disease under certain
circumstances
condi ons that provide opportuni es for pathogens - Ans immune suppression; changes in
the normal flora (changes in rela ve abundance); introduc on of normal flora into unusual site
in the body
Downtown Phoenix/ Mic 205 Exam 3 Daydiff/ 2 SETS
COMPILED WITH COMPLETE SOLUTION GUARANTEED
SUCCESS NEW EDITION 100% VERIFIED CORRECT
Prion Characteris cs - Ans single protein, two stable ter ary structures, mammals contain
gene, excess PrP produc on or muta ons in Prp gene, cause newly synthesized cellular form to
refold into prion form
Prion diseases - Ans only destroyed by incinera on
Drugs - Ans are used to control the growth of microorganisms in the body/ chemicals that
affect physiology
Controlling microbial growth in the body - Ans incinera on, UV rays from sunlight, Pressure
Chemotherapeu c Agents - Ans drugs that act against diseases; an microbials designed to
treat infec ons
Drug examples - Ans Penicillin (an bacterial); tylenol (pain med); insulin (sugar control); birth
control pills; zanax; viagra; caffiene; THC/Acid
Paul Ehrlich - Ans Salvarsan (arsphenamine) 1910- first modern chemotherapeu c agent;
arsenic compound used to treat syphilis
,Alexander Fleming - Ans Penicillin 1929- not available rou nely un l late 1940's; produced by
penicillium mold
Gerhard Domagk - Ans Sulfanilamide 1932- first widely available and prac cal an microbial
agent; inhibits metabolic synthesis of DNA and RNA nucleo des
Selec ve toxicity - Ans key factor for an microbial ac on in the body; kill the pathogen but not
the host
Inhibi on of cell wall synthesis - Ans prevent cross-linkage of NAM in newly synthesized
bacterial cell walls; no effect on exis ng pep doglycan; growing cells; no effect on plant/animal
cells
Beta lactams - Ans most prominent in this group; func onal of molecules are beta lactam rings
beta lactam rings - Ans binds to enzymes that cross link NAM subunits; cause bacteria to have
weakened cell walls and eventually lyse
Semisynthe c deriva ves of beta-lactams - Ans more stable in acidic environments; more
readily absorbed; less suscep ble to deac va on; more ac ve against more types of bacteria
Inhibi on of Protein synthesis - Ans prokaryo c ribosomes are 70s; selec vely targe ng and
inhibi ng transla on
Protein synthesis examples - Ans streptomycin; tetracyclines; erythromycin;
Disrup on of cytoplasmic membranes - Ans incorporated into the cytoplasmic membrane and
damage its integrity
,Amphotericin B - Ans a=aches to ergosterol found in fungal membranes- an fungal agent
Sulfa drugs - Ans inhibit metabolic pathways used for biosynthesis of DNA and RNA
nulceo des
Broad spectrum drugs - Ans may allow for secondary or superinfec ons to develop (killing of
normal flora reduces microbial antagonism)
External Infec ons: - Ans topical(local)- direct applica on of creams and pastes to the skin
Internal Infec ons: - Ans Oral-simple, but pa ents struggle following direc ons
Intramuscular- direct injec on into muscle ssue
Intravenous- direct administra on into blood stream via needle/catheter; achieves highest
levels of drug in body in shortest amount of me
Toxicity - Ans kidneys, liver, nerves
Tetracylcine - Ans froms calcium complexes that damage teeth and bones
allergies - Ans rare, but can be life threatening
Disrup on of normal flora - Ans yeast infec ons: overgrowth of Candida albicans in the vagina
or mouth
Pseudomembranous coli s: overgrowth of Clastridium difficile in colon due to clindamycin and
cepahlosporin an bio cs
, Development of Resistant Organisms - Ans bacteria acquire drug resistance in two way;
spontaneous muta ons of chromosomal genes/ acquisi on of an bio c resistance plasmids via
transforma on, transduc on, and conjuga on
Bacterial Resistance Mechanisms - Ans produc on of an enzyme that inac vates or destroys
an an bio c, ability to produce beta lactamase enzyme, preven on of drug entry, altera on of
the drugs receptor, altera on of the cells metabolic chemistry, proteins that pump drugs out of
the cell
High concentra on of drug maintained in pa ent for long enough me to kill all sensi ve cells
and inhibit others long enough for the immune system to destroy them - Ans Methods for
retarding resistance
Use an microbial agents in combina on(synergism) - Ans methods for retarding resistance
limit use of an microbials to necessary cases - Ans methods for retarding resistance
development of new varia ons - Ans methods for retarding resistance
Transient Microbiota - Ans remain in the body for only hours to months before disappearing;
cannot persist in the body due to compe on, body defenses, chemical/physical changes
Opportunis c Pathogens - Ans normal flora that can cause disease under certain
circumstances
condi ons that provide opportuni es for pathogens - Ans immune suppression; changes in
the normal flora (changes in rela ve abundance); introduc on of normal flora into unusual site
in the body
