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Pediatrics Core Review – 2025 | Exam Q&A (200+) | Neonatology, Cardiology, Infectious Disease, GI, Hematology

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This document contains over 200 high-yield pediatric exam questions and fully verified answers, making it a comprehensive review resource for the 2025 academic cycle. It is structured in a fast-paced Q&A format and designed to help medical and allied health students prepare for pediatric shelf exams, USMLE Step 2 CK, and clinical rotations. The content covers a broad spectrum of pediatric topics, with an emphasis on diagnosis, management, and classic clinical presentations. Topics include neonatology (e.g., meconium aspiration, hypoglycemia, neonatal resuscitation), congenital heart defects (e.g., Tetralogy of Fallot, VSD, PDA), and infectious diseases (e.g., TORCH infections, Kawasaki disease, viral exanthems). Gastrointestinal disorders such as Hirschsprung disease, pyloric stenosis, and intussusception are also addressed. Other sections explore pediatric hematology/oncology (e.g., sickle cell disease, ALL), endocrinology (e.g., congenital adrenal hyperplasia, type 1 diabetes), and common pediatric emergencies (e.g., epiglottitis, bronchiolitis, dehydration). With attention to both first-line treatments and diagnostic steps, this review enhances clinical reasoning and prepares students for the most tested topics in pediatrics. Best suited for: Medical students (MD/DO) Physician assistant (PA) students Nursing students in pediatric or family medicine tracks Students preparing for USMLE Step 2 CK or pediatric shelf exams Keywords: pediatrics, neonatology, congenital heart defects, TOF, VSD, PDA, TORCH infections, Kawasaki disease, exanthems, Hirschsprung, pyloric stenosis, intussusception, sickle cell anemia, pediatric oncology, epiglottitis, bronchiolitis, type 1 diabetes, CAH, pediatric emergencies, pediatric USMLE review

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Pediatrics Review - Emma Holliday
Ramahi 2025/2026 Exam Questions and
Answers | 100% Solved



What does the APGAR tell you? - 🧠ANSWER ✔✔General info about how

the newborn tolerated labor (1min) and the newborn's response to

resuscitation (5min)


What does the APGAR not tell you? - 🧠ANSWER ✔✔What to do next (does

not guide therapy)

How the baby will turn out (does NOT predict neurologic outcome)

,PE: When assessing Moro on an LGA newborn, the right arm remains

extended and medially rotated. - 🧠ANSWER ✔✔Erb-Duchenne C5-C6.

(Klumpke is C7-C8 + T1) Refer if not better by 3- 6mo for neuroplasty

PE: When palpating the clavicles on a LGA newborn, you feel crepitus and

discontinuity on the left. - 🧠ANSWER ✔✔Clavicular Fracture.


Will form a callus in 1wk. No tx needed. Can use figure of 8 splint.


"Edema. Crosses suture lines." - 🧠ANSWER ✔✔Caput succedaneum


"Fluctuance. Doesn't cross suture lines." - 🧠ANSWER

✔✔Cephalohematoma


- 🧠ANSWER ✔✔Mongolian Spots


- 🧠ANSWER ✔✔Nevus Simplex (Salmon Patch)


- 🧠ANSWER ✔✔Milia


Appears in up to half of newborns carried to term, usually between day 2-5

after birth. Resolves within first two weeks of life, and frequently individual

lesions will appear and disappear within minutes or hours. It is a benign

condition thought to cause no discomfort to the baby - 🧠ANSWER

✔✔Erythema toxicum

,- 🧠ANSWER ✔✔Strawberry Hemangioma


- 🧠ANSWER ✔✔Neonatal Acne


"an area of alopecia with orange colored nodular skin"

Remove before adolescence b/c it can undergo malignant degeneration. -

🧠ANSWER ✔✔Nevus Sebaceous


"thick, yellow/white oily scale on an inflammatory base".


What to do? Gently clean w/ mild shampoo - 🧠ANSWER ✔✔Seborrheic

Dermatitis

Two disorders screened for in every state because they are disastrous if

not caught early (and happen to be a contraindication to breast feeding...) -

🧠ANSWER ✔✔Phenylketonuria and Galactosemia.


Galactosemia. - 🧠ANSWER ✔✔Deficient G1p-uridyl- transferase. G1p

accum to damage kidney, liver, brain.

• Sxs = MR direct hyperbili & jaundice, ↓glc, cataracts, seizures.

• Predisposed to E. coli sepsis.

• No lactose por vida.



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STATEMENT. ALL RIGHTS RESERVED

, Phenylketonuria. - 🧠ANSWER ✔✔• Deficient Phe hydrolxalase.


• Sxs = MR, vomiting, athetosis, seizures, developmental delay over 1st

few mos

• Signs = fair hair, eyes, skin, musty smell.

• Low Phe diet.

3 days old, bili @ 10, direct is 0.5. Eating & pooping well. - 🧠ANSWER

✔✔Physiologic Jaundice. Gone by 5th DOL.


Liver conjugation not yet mature.

7 days old, bili @ 12, direct is 0.5. dry mucous membranes, not gaining

weight. - 🧠ANSWER ✔✔Breast feeding Jaundice. ↓feeding = dehydration =

retain meconium & re- absorb deconjugated bili.

14 days old, bili @ 12, direct is 0.5. Baby regained birth weight, otherwise

healthy. - 🧠ANSWER ✔✔Breast milk Jaundice. Breast milk has

glucuronidase and de-conj bili.

1 day old, bili @ 14, direct is 0.5. Are you worried? Next best test? If

positive? If negative? - 🧠ANSWER ✔✔Pathologic Jaundice = on 1st DOL,

bili >12, d-bili >2, rate of rise >5/day.

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