MCB 2050 Quiz University of Guelph exam
questions and Answers
A mutation that changes the reading frame of
RNA via the insertion or deletion of one or more
nucleotides - -Frame shift mutation
-Gene mutation which results in a change in the
way that introns are removed from the primary
RNA transcript - -Splicing mutation
-a mutation which results in a change in the
amino acid sequence of the protein product - -Missense mutation
-A mutation which results in the pre-mature
termination of translation, resulting in a
truncated protein product - -Non-sense mutation
-Autosomal recessive "loss of function" mutation
which results in the misfolding and degradation
of ion channels required for maintaining water
balance in epithelial cells - -Cystic Fibrosis
-Caused by a rare autosomal recessive "loss of
function" mutation which produces a nonfunctional
enzyme leading to the accumulation
of a molecule toxic to immune cells - -ADA-SCID
-Caused by an autosomal dominant "gain of
function" mutation in which an abnormal
number of trinucleotide repeats result in protein
misfolding and aggregate formation - -Huntington's disease
-A foriegn gene that has been introduced into a
cell or organism - -Transgene
-An organism that is composed of cells of
different genotypes - -Mosaic
-An individual with cells from two different
embryos - -Chimera
-The most common mutation to the CFTR gene responsible for the disease cystic fibrosis is
named ΔF508, indicating that
questions and Answers
A mutation that changes the reading frame of
RNA via the insertion or deletion of one or more
nucleotides - -Frame shift mutation
-Gene mutation which results in a change in the
way that introns are removed from the primary
RNA transcript - -Splicing mutation
-a mutation which results in a change in the
amino acid sequence of the protein product - -Missense mutation
-A mutation which results in the pre-mature
termination of translation, resulting in a
truncated protein product - -Non-sense mutation
-Autosomal recessive "loss of function" mutation
which results in the misfolding and degradation
of ion channels required for maintaining water
balance in epithelial cells - -Cystic Fibrosis
-Caused by a rare autosomal recessive "loss of
function" mutation which produces a nonfunctional
enzyme leading to the accumulation
of a molecule toxic to immune cells - -ADA-SCID
-Caused by an autosomal dominant "gain of
function" mutation in which an abnormal
number of trinucleotide repeats result in protein
misfolding and aggregate formation - -Huntington's disease
-A foriegn gene that has been introduced into a
cell or organism - -Transgene
-An organism that is composed of cells of
different genotypes - -Mosaic
-An individual with cells from two different
embryos - -Chimera
-The most common mutation to the CFTR gene responsible for the disease cystic fibrosis is
named ΔF508, indicating that
