Midterm Exam: NR 565 / NR565
(Latest Update )
Advanced Pharmacology
Fundamentals | Questions &
Answers | Grade A | 100% Correct –
Chamberlain
Question:
Opioid Abuse Screening Tool
Answer:
NIDA-Modified ASSIST
Question:
NSAIDs MOA
Answer:
Inhibition of COX-1: protection against MI and stroke; gastric erosion and
ulceration, bleeding tendencies, renal impairment
Inhibition of COX-2: suppression of inflammation, alleviation of pain,
reduction of fever, protection against colorectal cancer; renal impairment,
promotion of MI and stroke secondary to suppressing vasodilation
,Question:
NSAIDs Adverse Effects
Answer:
Gastric ulceration, bleeding renal impairment
MI, stroke (NOT aspirin)
Question:
Aspirin
Answer:
Nonselective inhibitor of cyclooxygenase
Reductions of inflammation, pain, and fever- result from inhibiting COX-2
Can protect against MI and stroke
Question:
Nonacetylated Salicylates
Answer:
Magnesium salicylate, sodium salicylate, salsalate
Inhibit COX-1 and COX-2
Used to treat arthritis, moderate pain, fever
Most common adverse effects are GI disturbances
,Question:
Nonacetylated Salicylates Contraindications
Answer:
Sodium salicylate should be avoided in patients on sodium-restricted diet
(HTN, heart failure)
Magnesium salicylate may accumulate to toxic levels in patients with chronic
renal insufficiency
Should not be given to children with chickenpox or influenza due to
possibility of precipitating Reye syndrome
Question:
Ibuprofen
Answer:
Inhibits cyclooxygenase and has anti inflammatory, analgesic, and antipyretic
actions
Used to treat fever, mild to moderate pain, and arthritis
Superior for dysmenorrhea; good inhibition of cyclooxygenase in uterine
smooth muscle
Rare hypersensitivity reaction is Stevens-Johnson syndrome
, Question:
Celecoxib MOA
Answer:
Selective inhibition of COX-2, the COX isoform whose products mediate
inflammation and pain
At therapeutic doses, celecoxib does not inhibit COX-1, the COX isoform
whose products protect the stomach, help maintain renal function, and
promote platelet aggregation
Question:
NSAID Use in Rheumatoid Arthritis
Answer:
Provide rapid relief of symptoms but do not prevent joint damage and do not
slow disease progression
Safer than DMARDs and glucocorticoids; require less vigorous monitoring
All NSAIDs have essentially equal antirheumatic effects; may be necessary to
try more than one as people will respond differently
(Latest Update )
Advanced Pharmacology
Fundamentals | Questions &
Answers | Grade A | 100% Correct –
Chamberlain
Question:
Opioid Abuse Screening Tool
Answer:
NIDA-Modified ASSIST
Question:
NSAIDs MOA
Answer:
Inhibition of COX-1: protection against MI and stroke; gastric erosion and
ulceration, bleeding tendencies, renal impairment
Inhibition of COX-2: suppression of inflammation, alleviation of pain,
reduction of fever, protection against colorectal cancer; renal impairment,
promotion of MI and stroke secondary to suppressing vasodilation
,Question:
NSAIDs Adverse Effects
Answer:
Gastric ulceration, bleeding renal impairment
MI, stroke (NOT aspirin)
Question:
Aspirin
Answer:
Nonselective inhibitor of cyclooxygenase
Reductions of inflammation, pain, and fever- result from inhibiting COX-2
Can protect against MI and stroke
Question:
Nonacetylated Salicylates
Answer:
Magnesium salicylate, sodium salicylate, salsalate
Inhibit COX-1 and COX-2
Used to treat arthritis, moderate pain, fever
Most common adverse effects are GI disturbances
,Question:
Nonacetylated Salicylates Contraindications
Answer:
Sodium salicylate should be avoided in patients on sodium-restricted diet
(HTN, heart failure)
Magnesium salicylate may accumulate to toxic levels in patients with chronic
renal insufficiency
Should not be given to children with chickenpox or influenza due to
possibility of precipitating Reye syndrome
Question:
Ibuprofen
Answer:
Inhibits cyclooxygenase and has anti inflammatory, analgesic, and antipyretic
actions
Used to treat fever, mild to moderate pain, and arthritis
Superior for dysmenorrhea; good inhibition of cyclooxygenase in uterine
smooth muscle
Rare hypersensitivity reaction is Stevens-Johnson syndrome
, Question:
Celecoxib MOA
Answer:
Selective inhibition of COX-2, the COX isoform whose products mediate
inflammation and pain
At therapeutic doses, celecoxib does not inhibit COX-1, the COX isoform
whose products protect the stomach, help maintain renal function, and
promote platelet aggregation
Question:
NSAID Use in Rheumatoid Arthritis
Answer:
Provide rapid relief of symptoms but do not prevent joint damage and do not
slow disease progression
Safer than DMARDs and glucocorticoids; require less vigorous monitoring
All NSAIDs have essentially equal antirheumatic effects; may be necessary to
try more than one as people will respond differently
