Exam Questions Clinical Immunology And Serology. A Laboratory
Perspective 4th Edition Dorresteyn (Ch 1 TO 25)
,TABLES OF CONTENTS
2 Nature of Antigens and the Major histocompatibility. Complex
3 Innate Immunity.
4 Adaptive Immunity.
5 Antibody. Structure and Function
6 Cy.tokines
7 Complement Sy.stem
8 Safety. and Quality. Management
9 Principles of Serological Testing
10 Precipitation and Agglutination Reactions
11 Labeled Immunoassay.s
12 Molecular Diagnostic Techniques
13 Flow Cy.tometry. and Laboratory. Automation
14 hy.persensitivity.
15 Autoimmunity.
16 Transplantation Immunology.
17 Tumor Immunology.
18 Immunoproliferative Diseases
19 Immunodeficiency. Diseases
20 Serological and Molecular Detection of Bacterial Infections
21 Spirochete Diseases
22 Serological and Molecular Diagnosis of Parasitic and Fungal Infections
23 Serology. and Molecular Detection of Viral Infections
24 Laboratory. Diagnosis of hIV Infection
25 Immunization and Vaccines
,Chapter 1. Introduction to Immunity and the Immune Sy.stem
Multiple Choice
1. Eosinophils are involved in the immune response against:
A. viruses.
B. intracellular bacteria.
C. parasites that cannot be phagocy.tized.
D. extracellular
bacteria. ANS: C
2. Which of the following are components of both innate and adaptive immune responses?
A. Immunoglobulins
B. T helper cells
C. Macrophages
D. B cells
ANS: C
3. The process by. which leukocy.tes are attracted to a specific area by. chemical messengers is called:
A. diapedesis.
B. degranulation.
C. chemotaxis.
D. opsonization
. ANS: C
4. Which of the following is a characteristic of natural killer cells?
A. They. mature in the thy.mus.
B. They. are smaller than B and T cells.
C. They. are a ty.pe of ly.mphocy.te.
D. They. are part of the adaptive immune
sy.stem. ANS: C
,5. Which of the following best describes diapedesis?
A. Movement toward increasing concentrations of a cy.tokine
B. Attachment of immunoglobulin to target cells
,C. Movement through blood vessel walls as cells exit the circulation
D. Engulfment of target
cells ANS: C
6. The most effective phagocy.tic and antigen-presenting cell is the:
A. neutrophil.
B. monocy.te.
C. dendritic cell.
D. macrophage
. ANS: C
7. Which of the following is characteristic of natural immunity.?
A. It involves memory..
B. T ly.mphocy.tes play. a major role.
C. It involves specificity..
D. Mechanisms are alway.s present and fully.
functional. ANS: D
8. All of the following cells are considered part of natural immunity. EXCEPT:
A. eosinophils.
B. B ly.mphocy.tes.
C. monocy.tes.
D. neutrophils
. ANS: B
9. Where does the specific immune response to a foreign antigen mainly. occur?
A. Ly.mph nodes
B. Blood
C. Bone marrow
D. Skin
ANS: A
10. Which white cell in the peripheral blood migrates into tissue to become a macrophage?
A. Eosinophil
B. Basophil
,C. Neutrophil
,D. Monocy.t
e ANS: D
11. A white blood cell that is 16 to 18 micrometers in diameter, has a horseshoe-shaped nucleus,
and is capable of phagocy.tosis is a:
A. neutrophil.
B. eosinophil.
C. basophil.
D. monocy.t
e. ANS: D
12. Pasteur's discovery. that older bacterial cultures would not cause disease in chickens but would
protect them from subsequent infection with more virulent strains is an example of:
A. attenuated vaccine.
B. natural immunity..
C. passive immunity..
D. cross-
immunity.. ANS:
A
13. Antibodies are secreted by.:
A. plasma cells.
B. B cells.
C. T cells.
D. dendritic
cells. ANS: A
14. Which of the following is characteristic of mucosal-associated ly.mphoid tissue?
A. It is one of the primary. ly.mphoid organs.
B. It clears pathogens from the bloodstream.
C. It includes the tonsils and the appendix.
D. It includes the liver and
spleen. ANS: C
,15. Acquired (adaptive) immunity. can be characterized as:
A. nonspecifically. activated.
B. immediately. responsive.
,C. neutrophil dependent.
D. involving
memory.. ANS: D
16. Which of the following is NOT a characteristic of neutrophils?
A. Congregate in the marginating pool in blood vessels
B. Capable of diapedesis
C. Granules that become bright orange with Wright stain
D. Segmented
nucleus ANS: C
17. The function of NK cells is to:
A. produce antibody..
B. phagocy.tize bacteria.
C. present antigen to T cells.
D. kill target cells such as tumor and virally. infected
cells. ANS: D
18. All of the following are involved in adaptive immunity. EXCEPT:
A. memory..
B. ly.mphocy.tes.
C. specificity..
D. neutrophils
. ANS: D
19. Which of the following is NOT a characteristic of a ly.mph node?
A. Filters interstitial fluid draining from tissues
B. Colonized with T and B cells
C. Between 1 and 25 mm in size
D. Considered a primary. or central ly.mphoid
organ ANS: D
20. All of the following are considered part of natural immunity. EXCEPT:
A. eosinophils.
B. ly.mphocy.tes.
, C. acute-phase reactants.
Perspective 4th Edition Dorresteyn (Ch 1 TO 25)
,TABLES OF CONTENTS
2 Nature of Antigens and the Major histocompatibility. Complex
3 Innate Immunity.
4 Adaptive Immunity.
5 Antibody. Structure and Function
6 Cy.tokines
7 Complement Sy.stem
8 Safety. and Quality. Management
9 Principles of Serological Testing
10 Precipitation and Agglutination Reactions
11 Labeled Immunoassay.s
12 Molecular Diagnostic Techniques
13 Flow Cy.tometry. and Laboratory. Automation
14 hy.persensitivity.
15 Autoimmunity.
16 Transplantation Immunology.
17 Tumor Immunology.
18 Immunoproliferative Diseases
19 Immunodeficiency. Diseases
20 Serological and Molecular Detection of Bacterial Infections
21 Spirochete Diseases
22 Serological and Molecular Diagnosis of Parasitic and Fungal Infections
23 Serology. and Molecular Detection of Viral Infections
24 Laboratory. Diagnosis of hIV Infection
25 Immunization and Vaccines
,Chapter 1. Introduction to Immunity and the Immune Sy.stem
Multiple Choice
1. Eosinophils are involved in the immune response against:
A. viruses.
B. intracellular bacteria.
C. parasites that cannot be phagocy.tized.
D. extracellular
bacteria. ANS: C
2. Which of the following are components of both innate and adaptive immune responses?
A. Immunoglobulins
B. T helper cells
C. Macrophages
D. B cells
ANS: C
3. The process by. which leukocy.tes are attracted to a specific area by. chemical messengers is called:
A. diapedesis.
B. degranulation.
C. chemotaxis.
D. opsonization
. ANS: C
4. Which of the following is a characteristic of natural killer cells?
A. They. mature in the thy.mus.
B. They. are smaller than B and T cells.
C. They. are a ty.pe of ly.mphocy.te.
D. They. are part of the adaptive immune
sy.stem. ANS: C
,5. Which of the following best describes diapedesis?
A. Movement toward increasing concentrations of a cy.tokine
B. Attachment of immunoglobulin to target cells
,C. Movement through blood vessel walls as cells exit the circulation
D. Engulfment of target
cells ANS: C
6. The most effective phagocy.tic and antigen-presenting cell is the:
A. neutrophil.
B. monocy.te.
C. dendritic cell.
D. macrophage
. ANS: C
7. Which of the following is characteristic of natural immunity.?
A. It involves memory..
B. T ly.mphocy.tes play. a major role.
C. It involves specificity..
D. Mechanisms are alway.s present and fully.
functional. ANS: D
8. All of the following cells are considered part of natural immunity. EXCEPT:
A. eosinophils.
B. B ly.mphocy.tes.
C. monocy.tes.
D. neutrophils
. ANS: B
9. Where does the specific immune response to a foreign antigen mainly. occur?
A. Ly.mph nodes
B. Blood
C. Bone marrow
D. Skin
ANS: A
10. Which white cell in the peripheral blood migrates into tissue to become a macrophage?
A. Eosinophil
B. Basophil
,C. Neutrophil
,D. Monocy.t
e ANS: D
11. A white blood cell that is 16 to 18 micrometers in diameter, has a horseshoe-shaped nucleus,
and is capable of phagocy.tosis is a:
A. neutrophil.
B. eosinophil.
C. basophil.
D. monocy.t
e. ANS: D
12. Pasteur's discovery. that older bacterial cultures would not cause disease in chickens but would
protect them from subsequent infection with more virulent strains is an example of:
A. attenuated vaccine.
B. natural immunity..
C. passive immunity..
D. cross-
immunity.. ANS:
A
13. Antibodies are secreted by.:
A. plasma cells.
B. B cells.
C. T cells.
D. dendritic
cells. ANS: A
14. Which of the following is characteristic of mucosal-associated ly.mphoid tissue?
A. It is one of the primary. ly.mphoid organs.
B. It clears pathogens from the bloodstream.
C. It includes the tonsils and the appendix.
D. It includes the liver and
spleen. ANS: C
,15. Acquired (adaptive) immunity. can be characterized as:
A. nonspecifically. activated.
B. immediately. responsive.
,C. neutrophil dependent.
D. involving
memory.. ANS: D
16. Which of the following is NOT a characteristic of neutrophils?
A. Congregate in the marginating pool in blood vessels
B. Capable of diapedesis
C. Granules that become bright orange with Wright stain
D. Segmented
nucleus ANS: C
17. The function of NK cells is to:
A. produce antibody..
B. phagocy.tize bacteria.
C. present antigen to T cells.
D. kill target cells such as tumor and virally. infected
cells. ANS: D
18. All of the following are involved in adaptive immunity. EXCEPT:
A. memory..
B. ly.mphocy.tes.
C. specificity..
D. neutrophils
. ANS: D
19. Which of the following is NOT a characteristic of a ly.mph node?
A. Filters interstitial fluid draining from tissues
B. Colonized with T and B cells
C. Between 1 and 25 mm in size
D. Considered a primary. or central ly.mphoid
organ ANS: D
20. All of the following are considered part of natural immunity. EXCEPT:
A. eosinophils.
B. ly.mphocy.tes.
, C. acute-phase reactants.
