Test bankforTietz Fundamentals ofClinical Chemistry and
c c c c c c c c
c Molecular Diagnostics,
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8th Editionby Nader Rifai,PhD
c c c c c c
Chapters 1- 49c c c c
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
c c c c c c c c
c
c c
Table of contents:
c c
I. Principles Of Laboratory Medicine
c c c c
Chapter 1. Clinical Chemistry, Molecular Diagnostics, and LaboratoryMedicine
c c c c c c c c
Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
c c c c c c c c c c c
Chapter 3. Clinical Evaluation of Methods
c c c c c
Chapter 4. Evidence-Based LaboratoryMedicine
c c c c
Chapter 5. Establishment and Use of Reference Values
c c c c c c c
Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
c c c c c c c c
Chapter 7. QualityManagement
c c c
II. Analytical Techniques And Instrumentation
c c c c
Chapter 8. Principles of Basic Techniques and LaboratorySafety
c c c c c c c c
Chapter 9. Optical Techniques
c c c
Chapter 10. Electrochemistryand Chemical Sensors
c c c c c
Chapter 11. Electrophoresis
c c
Chapter 12. Chromatography
c c
Chapter 13. Mass Spectrometry
c c c
Chapter 14. Enzyme and Rate Analyses
c c c c c
Chapter15. Immunochemical Techniques
c c c
Chapter 16 Automationc c
Chapter 17. Point-of-Care Instrumentation
c c c
III. Analytesc
Chapter 18. Amino Acids, Peptides, and Proteins
c c c c c c
Chapter 19. Serum Enzymes
c c c
Chapter 20. Tumor Markers and Cancer Genes
c c c c c c
Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid
c c c c c c c c c c c
Chapter 22. Carbohydrates
c c
Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
c c c c c c c c c
Chapter 24. Electrolytes and Blood Gases
c c c c c
Chapter 25. Hormones c c
Chapter 26. Catecholamines and Serotonin
c c c c
Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
c c c c c c
Chapter 28. Hemoglobin, Iron, and Bilirubin
c c c c c
Chapter 29. Porphyrins and Porphyrias
c c c c
Chapter 30. Therapeutic Drugs and Their Management
c c c c c c
Chapter 31. Clinical Toxicology
c c c
Chapter 32. Toxic Metals
c c c
IV. Pathophysiology
c
Chapter 33. Diabetes c c
,Chapter 34. Cardiovascular Disease
c c c
Chapter 35. KidneyDisease
c c c
Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
c c c c c c c c c c
Chapter 37. Liver Disease
c cc c
Chapter 38. Gastrointestinal and Pancreatic Diseases
c c c c c
Chapter 39. Disorders of Bone and Mineral Metabolism
c cc c c c c c
Chapter 40. Disorders of the PituitaryGland
c cc c c c c
Chapter 41. Disorders of the Adrenal Cortex
c c c c c c
Chapter 42. Thyroid Disorders
c c c
Chapter 43. Reproduction-Related Disorders
c c c
Chapter 44. Pregnancyand Prenatal Testing
c cc c c c
Chapter 45. Newborn Screening and Inborn Errors of Metabolism
c c c c c c c c
Chapter 46. Pharmacogenetics
c c
V. Molecular Diagnostics
c c
Chapter 47. Principles of Molecular Biology
c c c c c
Chapter 48. Nucleic Acid Techniques and Applications
c c c c c c
Chapter 49. Genomes and Nucleic Acid Alterations
c c c c c c
, Chapter01:Clinical Chemistry,Molecular Diagnostics,andLaboratoryMedicine Test
c c c c c c c c c
Bank
c
MULTIPLECHOICE c
1. An individual working in a clinical chemistry laboratory is married to a sales representative who
c c c c c c c c c c c c c c
works for a company that sells chemistry laboratory supplies. When the laboratory manager
c c c c c c c c c c c c c
requests alist of needed supplies, cost of supplies, and vendors, this individual onlyrecommends
c c c c c c c c c c c c c c c
the spouse’s companyas the vendor. This is considered to be a(n):
c c c c c c c c c c c c
a. accountingissue. c
b. possibleconflict of interest. c c c
c. maintenanceof confidentialityissue. c c c
d. problemwith resourceallocation. c c c
ANS: B c
Concernhas been raised overtheinterrelationships betweenpractitioners in themedical fieldand
c c c c c c c c c c c c c
commercial suppliers of drugs, devices, equipment, etc., to themedical profession.
c c c c c c c c c c c
Similarly, relationships have been scrutinized between clinical laboratorians and manufacturers c c c c c c c c c
and providers of diagnostic equipment and supplies. These concerns led the National Institutes of
c c c c c c c c c c c c c c
Health (NIH) in 1995 to require official institutional review of financial disclosurebyresearchers
c c c c c c c c c c c c c c
and management of situations inwhich disclosureindicates potentialconflicts of interest.
c c c c c c c c c c c c
DIF: 1 REF: Page 4-5 cc c c OBJ: 6 |7 c c c
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce the
c c c c c c c c c c c c c c c
pain followingher recent surgery. A friend of the patient claims that the same painkiller“worked
c c c c c c c c c c c c c c c c
wonders” to reduce her pain after the same surgery. The physician states that the differencein the
c c c c c c c c c c c c c c c c c
effect of thedrugmight be caused by
c c , which is studied in
c c c c c c c c c c
pharmacogenetics.
c
a. epidemiology
b. aninheriteddisease c c
c. aconflictofinterest c c c
d. ageneticvariation in drug-metabolizingenzymes
c c c c c
ANS: D c
Pharmacogenetics is thestudyofthe geneticvariation ofdrugmetabolism between c c c c c c c c c c c
individuals.
c
DIF: 1 REF: Page 3 cc c c OBJ: 1 c
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the name of
c c c c c c c c c c c c c c c c
a close friend printed onthe bar-coded label. Thegenetic test that isordered on thefriend’s sample
c c c c c c c c c c c c c c c c c c
would provide diagnostic information about a disorder that has a poor prognosis, and the test is
c c c c c c c c c c c c c c c c
usually performed by John. He asks a fellow employee to analyzethesample forhim and not
c c c c c c c c c c c c c c c c c
divulge the results. This ethical issue concerns:
c c c c c c c
a. confidentialityofpatient geneticand medical information. c c c c c c
b. aconflict ofinterest. c c c
c. resourceallocation. c
d. diagnosticaccuracy. c
c c c c c c c c
c Molecular Diagnostics,
c c
8th Editionby Nader Rifai,PhD
c c c c c c
Chapters 1- 49c c c c
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
c c c c c c c c
c
c c
Table of contents:
c c
I. Principles Of Laboratory Medicine
c c c c
Chapter 1. Clinical Chemistry, Molecular Diagnostics, and LaboratoryMedicine
c c c c c c c c
Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
c c c c c c c c c c c
Chapter 3. Clinical Evaluation of Methods
c c c c c
Chapter 4. Evidence-Based LaboratoryMedicine
c c c c
Chapter 5. Establishment and Use of Reference Values
c c c c c c c
Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
c c c c c c c c
Chapter 7. QualityManagement
c c c
II. Analytical Techniques And Instrumentation
c c c c
Chapter 8. Principles of Basic Techniques and LaboratorySafety
c c c c c c c c
Chapter 9. Optical Techniques
c c c
Chapter 10. Electrochemistryand Chemical Sensors
c c c c c
Chapter 11. Electrophoresis
c c
Chapter 12. Chromatography
c c
Chapter 13. Mass Spectrometry
c c c
Chapter 14. Enzyme and Rate Analyses
c c c c c
Chapter15. Immunochemical Techniques
c c c
Chapter 16 Automationc c
Chapter 17. Point-of-Care Instrumentation
c c c
III. Analytesc
Chapter 18. Amino Acids, Peptides, and Proteins
c c c c c c
Chapter 19. Serum Enzymes
c c c
Chapter 20. Tumor Markers and Cancer Genes
c c c c c c
Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid
c c c c c c c c c c c
Chapter 22. Carbohydrates
c c
Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
c c c c c c c c c
Chapter 24. Electrolytes and Blood Gases
c c c c c
Chapter 25. Hormones c c
Chapter 26. Catecholamines and Serotonin
c c c c
Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
c c c c c c
Chapter 28. Hemoglobin, Iron, and Bilirubin
c c c c c
Chapter 29. Porphyrins and Porphyrias
c c c c
Chapter 30. Therapeutic Drugs and Their Management
c c c c c c
Chapter 31. Clinical Toxicology
c c c
Chapter 32. Toxic Metals
c c c
IV. Pathophysiology
c
Chapter 33. Diabetes c c
,Chapter 34. Cardiovascular Disease
c c c
Chapter 35. KidneyDisease
c c c
Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
c c c c c c c c c c
Chapter 37. Liver Disease
c cc c
Chapter 38. Gastrointestinal and Pancreatic Diseases
c c c c c
Chapter 39. Disorders of Bone and Mineral Metabolism
c cc c c c c c
Chapter 40. Disorders of the PituitaryGland
c cc c c c c
Chapter 41. Disorders of the Adrenal Cortex
c c c c c c
Chapter 42. Thyroid Disorders
c c c
Chapter 43. Reproduction-Related Disorders
c c c
Chapter 44. Pregnancyand Prenatal Testing
c cc c c c
Chapter 45. Newborn Screening and Inborn Errors of Metabolism
c c c c c c c c
Chapter 46. Pharmacogenetics
c c
V. Molecular Diagnostics
c c
Chapter 47. Principles of Molecular Biology
c c c c c
Chapter 48. Nucleic Acid Techniques and Applications
c c c c c c
Chapter 49. Genomes and Nucleic Acid Alterations
c c c c c c
, Chapter01:Clinical Chemistry,Molecular Diagnostics,andLaboratoryMedicine Test
c c c c c c c c c
Bank
c
MULTIPLECHOICE c
1. An individual working in a clinical chemistry laboratory is married to a sales representative who
c c c c c c c c c c c c c c
works for a company that sells chemistry laboratory supplies. When the laboratory manager
c c c c c c c c c c c c c
requests alist of needed supplies, cost of supplies, and vendors, this individual onlyrecommends
c c c c c c c c c c c c c c c
the spouse’s companyas the vendor. This is considered to be a(n):
c c c c c c c c c c c c
a. accountingissue. c
b. possibleconflict of interest. c c c
c. maintenanceof confidentialityissue. c c c
d. problemwith resourceallocation. c c c
ANS: B c
Concernhas been raised overtheinterrelationships betweenpractitioners in themedical fieldand
c c c c c c c c c c c c c
commercial suppliers of drugs, devices, equipment, etc., to themedical profession.
c c c c c c c c c c c
Similarly, relationships have been scrutinized between clinical laboratorians and manufacturers c c c c c c c c c
and providers of diagnostic equipment and supplies. These concerns led the National Institutes of
c c c c c c c c c c c c c c
Health (NIH) in 1995 to require official institutional review of financial disclosurebyresearchers
c c c c c c c c c c c c c c
and management of situations inwhich disclosureindicates potentialconflicts of interest.
c c c c c c c c c c c c
DIF: 1 REF: Page 4-5 cc c c OBJ: 6 |7 c c c
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce the
c c c c c c c c c c c c c c c
pain followingher recent surgery. A friend of the patient claims that the same painkiller“worked
c c c c c c c c c c c c c c c c
wonders” to reduce her pain after the same surgery. The physician states that the differencein the
c c c c c c c c c c c c c c c c c
effect of thedrugmight be caused by
c c , which is studied in
c c c c c c c c c c
pharmacogenetics.
c
a. epidemiology
b. aninheriteddisease c c
c. aconflictofinterest c c c
d. ageneticvariation in drug-metabolizingenzymes
c c c c c
ANS: D c
Pharmacogenetics is thestudyofthe geneticvariation ofdrugmetabolism between c c c c c c c c c c c
individuals.
c
DIF: 1 REF: Page 3 cc c c OBJ: 1 c
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the name of
c c c c c c c c c c c c c c c c
a close friend printed onthe bar-coded label. Thegenetic test that isordered on thefriend’s sample
c c c c c c c c c c c c c c c c c c
would provide diagnostic information about a disorder that has a poor prognosis, and the test is
c c c c c c c c c c c c c c c c
usually performed by John. He asks a fellow employee to analyzethesample forhim and not
c c c c c c c c c c c c c c c c c
divulge the results. This ethical issue concerns:
c c c c c c c
a. confidentialityofpatient geneticand medical information. c c c c c c
b. aconflict ofinterest. c c c
c. resourceallocation. c
d. diagnosticaccuracy. c
