TEST BANK st
Cellular and Molecular Immunology
st st st
Abul Abbas, Andrew Lichtman, and Shiv Pillai
st st st st st st
10th Edition
st
,Table of Contents
st st
Chapter 01 Properties and Overview of Immune Responses
st st st st st st st 1
Chapter 02 Cells and Tissues of the Immune System
st st st st st st st st 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
st st st st st st st 6
Chapter 04 Innate Immunity
st st st 10
Chapter 05 Antibodies and Antigens
st st st st 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
st st st st st st st st st st st
Histocompatibility Complex Molecules st st 20
Chapter 07 Immune Receptors and Signal Transduction
st st st st st st 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
st st st st st st st st 30
Chapter 09 Activation of T Lymphocytes
st st st st st 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
st st st st st st st st st 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
st st st st st st st st st 42
Chapter 12 B Cell Activation and Antibody Production
st st st st st st st 46
Chapter 13 Effector Mechanisms of Humoral Immunity
st st st st st st 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
st st st st st st st st st st st 56
Chapter 15 Immunologic Tolerance and Autoimmunity
st st st st st 62
Chapter 16 Immunity to Microbes
st st st st 67
Chapter 17 Transplantation Immunology
st st st 72
Chapter 18 Tumor Immunology
st st st 77
Chapter 19 Hypersensitivity Disorders
st st st 81
Chapter 20 Allergy
st st 86
Chapter 21 Primary and Acquired Immunodeficiencies
st st st st st 89
,Chapter 01: Properties and Overview of Immune Responses
st st st st st st st
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
st st st st st st st st st
MULTIPLE CHOICE st
1. The principal function of the immune system is:
st st st st st st st
a. Defense against cancer st st
b. Repair of injured tissues st st st
c. Defense against microbial infections st st st
d. Prevention of inflammatory diseases st st st
e. Protection against environmental toxins st st st
ANS: C s t
The immune system has evolved in the setting of selective pressures imposed by microbial infe
st st st st st st st st st st st st st st
ctions. Although immune responses to cancer may occur, the concept that “immunosurveillan
st st st st st st st st st st st
ce” against cancer is a principal function of the immune system is controversial. Repair of inju
st st st st st st st st st st st st st st st
red tissues may be a secondary consequence of the immune responses and inflammation. Alth
st st st st st st st st st st st st st
ough the immune system has regulatory features that are needed to prevent excessive inflamm
st st st st st st st st st st st st st
ation, prevention of inflammatory diseases is not a primary function. The immune system can
st st st st st st st st st st st st st st
protect against microbial toxins, but it generally does not offer protection against toxins of non
st st st st st st st st st st st st st st
biologic origin. st
2. Which of the following infectious diseases was prevented by the first successful va
st st st st st st st st st st st st
ccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C s t
In 1798, Edward Jenner reported the first intentional successful vaccination, which was again
st st st st st st st st st st st st
st smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980, smallpox
st st st st st st st st st st st st st st st st s
was reported to be eradicated worldwide by a vaccination program. Effective vaccines agains
t st st st st st st st st st st st st
t tetanus toxin, rubella virus, and poliovirus were developed in the 20th century and are widely
st st st st st st st st st st st st st st st
used. There is no effective vaccine against Mycobacterium tuberculosis.
st st st st st st st st st
3. Which of the following is a unique property of the adaptive immune system?
st st st st st st st st st st st st
a. Highly diverse repertoire of specificities for antigens st st st st st st
b. Self-nonself discrimination st
c. Recognition of microbial structures byboth cell-associated and soluble receptors st st st st st st st st st
d. Protection against viral infections st st st
e. Responses that have the same kinetics and magnitude on repeated exposure to the sa st st st st st st st st st st st st st
me microbe st
ANS: A s t
, Highly diverse repertoires of specificities for antigens are found only in T and B lymphocytes,
st st st st st st st st st st st st st st
which are the central cellular components of the adaptive immune system. Both the innate and
st st st st st st st st st st st st st st st
the adaptive immune systems use cell-
st st st st st st
associated and soluble receptors to recognize microbes, display some degree of self-
st st st st st st st st st st st
nonself discrimination, and protect against viruses. On repeated exposure to the same microbe
st st st st st st st st st st st st
, the adaptive immune response becomes more rapid and of greater magnitude; this is the mani
st st st st st st st st st st st st st st st
festation of memory. st st
4. Antibodies and T lymphocytes are the respective mediators of which two types of im st st st st st st st st st st st st st
munity?
a. Innate and adaptive st st
b. Passive and active st st
c. Specific and nonspecific st st
d. Humoral and cell-mediated st st
e. Adult and neonatal st st
ANS: D s t
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocytes pro
st st st st st st st st st st st st st
duce antibodies, which are the recognition and effector molecules of humoral immune respons
st st st st st st st st st st st st
es to extracellular pathogens. T cells recognize and promote eradication of intracellular pathog
st st st st st st st st st st st st
ens in cell- st st
mediated immunity. Passive and active immunity both can be mediated by either B or T lympho
st st st st st st st st st st st st st st st
cytes. Specific immunity is another term for adaptive immunity. Both B and T lymphocytes part
st st st st st st st st st st st st st st
icipate in adult adaptive immunity but are still developing in the neonatal period.
st st st st st st st st st st st st
5. The two major functional classes of effector T lymphocytes are:
st st st st st st st st st
a. Helper T lymphocytes and cytotoxic T lymphocytes st st st st st st
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes st st st st
c. Memory T cells and effector T cells st st st st st st
d. Helper cells and antigen-presenting cells st st st st
e. Cytotoxic T lymphocytes and target cells st st st st st
ANS: A s t
T cells can be classified into effector subsets that perform different effector functions. Most eff
st st st st st st st st st st st st st st
ector T cells are either helper T lymphocytes, which enhance the responses of other immune c
st st st st st st st st st st st st st st st
ells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes, which direct
st st st st st st st st st st st st st
ly kill infected cells. Natural killer cells are not T lymphocytes.
st st st st st st st st st st
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. st st st st st st st st st st st st st st
6. Which of the following cell types is required for all adaptive humoral immune responses?
st st st st st st st st st st st st st
a. Natural killer cells st st
b. Dendritic cells st
c. Cytolytic T lymphocytes st st
d. B lymphocytes st
e. Helper T lymphocytes st st
ANS: D s t
Humoral immune responses are antibody- st st st st
mediated immune responses, and all antibodies are made by B lymphocytes and no other cel
st st st st st st st st st st st st st st
l type.
st
Cellular and Molecular Immunology
st st st
Abul Abbas, Andrew Lichtman, and Shiv Pillai
st st st st st st
10th Edition
st
,Table of Contents
st st
Chapter 01 Properties and Overview of Immune Responses
st st st st st st st 1
Chapter 02 Cells and Tissues of the Immune System
st st st st st st st st 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
st st st st st st st 6
Chapter 04 Innate Immunity
st st st 10
Chapter 05 Antibodies and Antigens
st st st st 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
st st st st st st st st st st st
Histocompatibility Complex Molecules st st 20
Chapter 07 Immune Receptors and Signal Transduction
st st st st st st 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
st st st st st st st st 30
Chapter 09 Activation of T Lymphocytes
st st st st st 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
st st st st st st st st st 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
st st st st st st st st st 42
Chapter 12 B Cell Activation and Antibody Production
st st st st st st st 46
Chapter 13 Effector Mechanisms of Humoral Immunity
st st st st st st 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
st st st st st st st st st st st 56
Chapter 15 Immunologic Tolerance and Autoimmunity
st st st st st 62
Chapter 16 Immunity to Microbes
st st st st 67
Chapter 17 Transplantation Immunology
st st st 72
Chapter 18 Tumor Immunology
st st st 77
Chapter 19 Hypersensitivity Disorders
st st st 81
Chapter 20 Allergy
st st 86
Chapter 21 Primary and Acquired Immunodeficiencies
st st st st st 89
,Chapter 01: Properties and Overview of Immune Responses
st st st st st st st
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
st st st st st st st st st
MULTIPLE CHOICE st
1. The principal function of the immune system is:
st st st st st st st
a. Defense against cancer st st
b. Repair of injured tissues st st st
c. Defense against microbial infections st st st
d. Prevention of inflammatory diseases st st st
e. Protection against environmental toxins st st st
ANS: C s t
The immune system has evolved in the setting of selective pressures imposed by microbial infe
st st st st st st st st st st st st st st
ctions. Although immune responses to cancer may occur, the concept that “immunosurveillan
st st st st st st st st st st st
ce” against cancer is a principal function of the immune system is controversial. Repair of inju
st st st st st st st st st st st st st st st
red tissues may be a secondary consequence of the immune responses and inflammation. Alth
st st st st st st st st st st st st st
ough the immune system has regulatory features that are needed to prevent excessive inflamm
st st st st st st st st st st st st st
ation, prevention of inflammatory diseases is not a primary function. The immune system can
st st st st st st st st st st st st st st
protect against microbial toxins, but it generally does not offer protection against toxins of non
st st st st st st st st st st st st st st
biologic origin. st
2. Which of the following infectious diseases was prevented by the first successful va
st st st st st st st st st st st st
ccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C s t
In 1798, Edward Jenner reported the first intentional successful vaccination, which was again
st st st st st st st st st st st st
st smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980, smallpox
st st st st st st st st st st st st st st st st s
was reported to be eradicated worldwide by a vaccination program. Effective vaccines agains
t st st st st st st st st st st st st
t tetanus toxin, rubella virus, and poliovirus were developed in the 20th century and are widely
st st st st st st st st st st st st st st st
used. There is no effective vaccine against Mycobacterium tuberculosis.
st st st st st st st st st
3. Which of the following is a unique property of the adaptive immune system?
st st st st st st st st st st st st
a. Highly diverse repertoire of specificities for antigens st st st st st st
b. Self-nonself discrimination st
c. Recognition of microbial structures byboth cell-associated and soluble receptors st st st st st st st st st
d. Protection against viral infections st st st
e. Responses that have the same kinetics and magnitude on repeated exposure to the sa st st st st st st st st st st st st st
me microbe st
ANS: A s t
, Highly diverse repertoires of specificities for antigens are found only in T and B lymphocytes,
st st st st st st st st st st st st st st
which are the central cellular components of the adaptive immune system. Both the innate and
st st st st st st st st st st st st st st st
the adaptive immune systems use cell-
st st st st st st
associated and soluble receptors to recognize microbes, display some degree of self-
st st st st st st st st st st st
nonself discrimination, and protect against viruses. On repeated exposure to the same microbe
st st st st st st st st st st st st
, the adaptive immune response becomes more rapid and of greater magnitude; this is the mani
st st st st st st st st st st st st st st st
festation of memory. st st
4. Antibodies and T lymphocytes are the respective mediators of which two types of im st st st st st st st st st st st st st
munity?
a. Innate and adaptive st st
b. Passive and active st st
c. Specific and nonspecific st st
d. Humoral and cell-mediated st st
e. Adult and neonatal st st
ANS: D s t
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocytes pro
st st st st st st st st st st st st st
duce antibodies, which are the recognition and effector molecules of humoral immune respons
st st st st st st st st st st st st
es to extracellular pathogens. T cells recognize and promote eradication of intracellular pathog
st st st st st st st st st st st st
ens in cell- st st
mediated immunity. Passive and active immunity both can be mediated by either B or T lympho
st st st st st st st st st st st st st st st
cytes. Specific immunity is another term for adaptive immunity. Both B and T lymphocytes part
st st st st st st st st st st st st st st
icipate in adult adaptive immunity but are still developing in the neonatal period.
st st st st st st st st st st st st
5. The two major functional classes of effector T lymphocytes are:
st st st st st st st st st
a. Helper T lymphocytes and cytotoxic T lymphocytes st st st st st st
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes st st st st
c. Memory T cells and effector T cells st st st st st st
d. Helper cells and antigen-presenting cells st st st st
e. Cytotoxic T lymphocytes and target cells st st st st st
ANS: A s t
T cells can be classified into effector subsets that perform different effector functions. Most eff
st st st st st st st st st st st st st st
ector T cells are either helper T lymphocytes, which enhance the responses of other immune c
st st st st st st st st st st st st st st st
ells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes, which direct
st st st st st st st st st st st st st
ly kill infected cells. Natural killer cells are not T lymphocytes.
st st st st st st st st st st
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. st st st st st st st st st st st st st st
6. Which of the following cell types is required for all adaptive humoral immune responses?
st st st st st st st st st st st st st
a. Natural killer cells st st
b. Dendritic cells st
c. Cytolytic T lymphocytes st st
d. B lymphocytes st
e. Helper T lymphocytes st st
ANS: D s t
Humoral immune responses are antibody- st st st st
mediated immune responses, and all antibodies are made by B lymphocytes and no other cel
st st st st st st st st st st st st st st
l type.
st
