Test bank for Tietz Fundamentals of Clinical Chemistry
and Molecular Diagnostics,
8th Edition by Nader Rifai, PhD
Chapters 1 - 49
,TietzcxFundamentalscxofcxClinicalcxChemistrycxandcxMolecularcxDiagnosticscx8thc x EditioncxTestcxBank
Tablecxofcxcontents:
I.cxPrinciplescxOfcxLaboratorycxMedicine
Chaptercx1.cxClinicalcxChemistry,cxMolecularcxDiagnostics,cxandcxLaboratorycxMedicine
Chaptercx2.cxSelectioncxandcxAnalyticalcxEvaluationcxofcxMethodscx—
cxWithcxStatisticalcxTechniques
Chaptercx3.cxClinicalcxEvaluationcxofcxMethods
Chaptercx4.cxEvidence-BasedcxLaboratorycxMedicine
Chaptercx5.cxEstablishmentcxandcxUsecxofcxReferencecxValues
Chaptercx6.cxSpecimencxCollection,cxProcessing,cxandcxOthercxPreanalyticalcxVariables
Chaptercx7.cxQualitycxManagement
II.cxAnalyticalcxTechniquescxAndcxInstrumentation
Chaptercx8.cxPrinciplescxofcxBasiccxTechniquescxandcxLaboratorycxSafety
Chaptercx9.cxOpticalcxTechniques
Chaptercx10.cxElectrochemistrycxandcxChemicalcxSensors
Chaptercx11.cxElectrophoresis
Chaptercx12.cxChromatography
Chaptercx13.cxMasscxSpectrometry
Chaptercx14.cxEnzymecxandcxRatecxAnalyses
Chaptercx15.cxImmunochemicalcxTechniques
Chaptercx16cxAutomation
Chaptercx17.cxPoint-of-CarecxInstrumentation
III.c x Analytes
Chaptercx18.cxAminocxAcids,cxPeptides,cxandcxProteins
Chaptercx19.cxSerumcxEnzymes
Chaptercx20.cxTumorcxMarkerscxandcxCancercxGenes
Chaptercx21.cxKidneycxFunctioncxTestscx—cxCreatinine,cxGFR,cxUrea,cxandcxUriccxAcid
Chaptercx22.cxCarbohydrates
Chaptercx23.cxLipids,cxLipoproteins,cxApolipoproteins,cxandcxOthercxCardiaccxRiskcxFactors
Chaptercx24.cxElectrolytescxandcxBloodcxGases
Chaptercx25.cxHormones
Chaptercx26.c x CatecholaminescxandcxSerotonin
Chaptercx27.c x Vitamins,cxTracecxElements,cxNutritionalcxAssessment
Chaptercx28.cxHemoglobin,cxIron,cxandcxBilirubin
Chaptercx29.cxPorphyrinscxandcxPorphyrias
Chaptercx30.cxTherapeuticcxDrugscxandcxTheircxManagement
Chaptercx31.cxClinicalcxToxicology
Chaptercx32.c x ToxiccxMetals
IV.c x Pathophysiology
Chaptercx33.cxDiabetes
,Chaptercx34.c x CardiovascularcxDisease
Chaptercx35.cxKidneycxDisease
Chaptercx36.c x PhysiologycxandcxDisorderscxofcxWater,cxElectrolyte,cxandcxAcid-BasecxMetabolism
Chaptercx37.cxcxLivercxDisease
Chaptercx38.c x GastrointestinalcxandcxPancreaticcxDiseases
Chaptercx39.cxcxDisorderscxofcxBonecxandcxMineralcxMetabolism
Chaptercx40.cxcxDisorderscxofcxthecxPituitarycxGland
Chaptercx41.c x DisorderscxofcxthecxAdrenalcxCortex
Chaptercx42.c x ThyroidcxDisorders
Chaptercx43.c x Reproduction-RelatedcxDisorders
Chaptercx44.cxcxPregnancycxandcxPrenatalcxTesting
Chaptercx45.c x NewborncxScreeningcxandcxInborncxErrorscxofcxMetabolism
Chaptercx46.cxPharmacogenetics
V.c x MolecularcxDiagnostics
Chaptercx47.cxPrinciplescxofcxMolecularcxBiology
Chaptercx48.cxNucleiccxAcidcxTechniquescxandcxApplications
Chaptercx49.cxGenomescxandcxNucleiccxAcidcxAlterations
, Chaptercx01:cxClinicalcxChemistry,cxMolecularcxDiagnostics,cxandcxLaboratorycxMedicinec
xTestcB
x ank
MULTIPLEcxCHOICE
1. Ancxindividualcxworkingcxincxacxclinicalcxchemistrycxlaboratorycxiscxmarriedcxtocxacxsalescxreprese
ntativecxwhocxworkscxforcxacxcompanycxthatcxsellscxchemistrycxlaboratorycxsupplies.cxWhencxthecxl
aboratorycxmanagercxrequestscxacxlistcxofcxneededcxsupplies,cxcostcxofcxsupplies,cxandcxvendors,cxth
iscxindividualcxonlycrx ecommendscxthecxspouse’scxcompanycxascxthecxvendor.cxThiscxiscxconsideredc
xtocxbecxa(n):
a. accountingcxissue.
b. possiblecxconflictcxofcxinterest.
c. maintenancecxofcxconfidentialitycxissue.
d. problemcxwithcxresourcecxallocation.
ANS:c x B
Concerncxhascxbeencxraisedcxovercxthecxinterrelationshipscxbetweencxpractitionerscxincxthecxmedica
lcxfieldcax ndcxcommercialcxsupplierscxofcxdrugs,cxdevices,cxequipment,cxetc.,cxtocxthecxmedicalcxprof
ession.
Similarly,cxrelationshipscxhavecxbeencxscrutinizedcxbetweencxclinicalcxlaboratorianscxandcxmanufa
cturerscxandcxproviderscxofcxdiagnosticcxequipmentcxandcxsupplies.cxThesecxconcernscxledcxthecxNat
ionalcxInstitutescxofcxHealthcx(NIH)cxincx1995cxtocxrequirecxofficialcxinstitutionalcxreviewcxofcxfinan
cialcxdisclosurecxbycxresearcherscxandcxmanagementcxofcxsituationscxincxwhichcxdisclosurecxindicate
scxpotentialcxconflictscxofcxinterest.
DIF: 1 REF:cxcxcxPagecx4-5 OBJ:c x 6cx|cx7
2. Acxpatientcxvisitscxhercxphysiciancxstatingcxthatcxhercxprescribedcxpainkillercxiscxnotcxworkingcxtoc
xreducecxthecxpaincxfollowingcxhercxrecentcxsurgery.cxAcxfriendcxofcxthecxpatientcxclaimscxthatcxthec
xsamecxpainkillercx“workedcxwonders”cxtocxreducecxhercxpaincxaftercxthecxsamecxsurgery.cxThecxph
ysiciancxstatescxthatcxthecxdifferencecxincxthecxeffectcxofcxthecxdrugcxmightcxbecxcausedcxby
,cxwhichcxiscxstudiedcxincxpharmacogenetics.
a. epidemiology
b. ancxinheritedcxdisease
c. acxconflictcxofcxinterest
d. acxgeneticcxvariationcxincxdrug-metabolizingcxenzymes
ANS:c x D
Pharmacogeneticscxiscxthecxstudycxofcxthecxgeneticcxvariationcxofcxdrugcxmetabolismcxbe
tweencixndividuals.
DIF: 1 REF:cxcxcxPagecx3 OBJ:c x 1
3. Johncxworkscxincxacxmolecularcxdiagnosticscxlaboratorycxandcxreceivescxacxbloodcxsamplecxthatcxh
ascxthecxnamecxofcxacxclosecxfriendcxprintedcxoncxthecxbar-
codedcxlabel.cxThecxgeneticcxtestcxthatcxiscxorderedcxoncxthecfx riend’scxsamplecxwouldcxprovidecxdi
agnosticcxinformationcxaboutcxacxdisordercxthatcxhascxacxpoorcxprognosis,cxandcxthecxtestcxiscxusua
llycxperformedcxbycxJohn.cxHecxaskscxacxfellowcxemployeecxtocxanalyzectxhecxsamplecxforcxhimcxan
dcxnotcxdivulgecxthecxresults.cxThiscxethicalcxissuecxconcerns:
a. confidentialitycxofcxpatientcxgeneticcxandcxmedicalcxinformation.
b. acxconflictcxofcxinterest.
c. resourcecxallocation.
d. diagnosticcxaccuracy.
and Molecular Diagnostics,
8th Edition by Nader Rifai, PhD
Chapters 1 - 49
,TietzcxFundamentalscxofcxClinicalcxChemistrycxandcxMolecularcxDiagnosticscx8thc x EditioncxTestcxBank
Tablecxofcxcontents:
I.cxPrinciplescxOfcxLaboratorycxMedicine
Chaptercx1.cxClinicalcxChemistry,cxMolecularcxDiagnostics,cxandcxLaboratorycxMedicine
Chaptercx2.cxSelectioncxandcxAnalyticalcxEvaluationcxofcxMethodscx—
cxWithcxStatisticalcxTechniques
Chaptercx3.cxClinicalcxEvaluationcxofcxMethods
Chaptercx4.cxEvidence-BasedcxLaboratorycxMedicine
Chaptercx5.cxEstablishmentcxandcxUsecxofcxReferencecxValues
Chaptercx6.cxSpecimencxCollection,cxProcessing,cxandcxOthercxPreanalyticalcxVariables
Chaptercx7.cxQualitycxManagement
II.cxAnalyticalcxTechniquescxAndcxInstrumentation
Chaptercx8.cxPrinciplescxofcxBasiccxTechniquescxandcxLaboratorycxSafety
Chaptercx9.cxOpticalcxTechniques
Chaptercx10.cxElectrochemistrycxandcxChemicalcxSensors
Chaptercx11.cxElectrophoresis
Chaptercx12.cxChromatography
Chaptercx13.cxMasscxSpectrometry
Chaptercx14.cxEnzymecxandcxRatecxAnalyses
Chaptercx15.cxImmunochemicalcxTechniques
Chaptercx16cxAutomation
Chaptercx17.cxPoint-of-CarecxInstrumentation
III.c x Analytes
Chaptercx18.cxAminocxAcids,cxPeptides,cxandcxProteins
Chaptercx19.cxSerumcxEnzymes
Chaptercx20.cxTumorcxMarkerscxandcxCancercxGenes
Chaptercx21.cxKidneycxFunctioncxTestscx—cxCreatinine,cxGFR,cxUrea,cxandcxUriccxAcid
Chaptercx22.cxCarbohydrates
Chaptercx23.cxLipids,cxLipoproteins,cxApolipoproteins,cxandcxOthercxCardiaccxRiskcxFactors
Chaptercx24.cxElectrolytescxandcxBloodcxGases
Chaptercx25.cxHormones
Chaptercx26.c x CatecholaminescxandcxSerotonin
Chaptercx27.c x Vitamins,cxTracecxElements,cxNutritionalcxAssessment
Chaptercx28.cxHemoglobin,cxIron,cxandcxBilirubin
Chaptercx29.cxPorphyrinscxandcxPorphyrias
Chaptercx30.cxTherapeuticcxDrugscxandcxTheircxManagement
Chaptercx31.cxClinicalcxToxicology
Chaptercx32.c x ToxiccxMetals
IV.c x Pathophysiology
Chaptercx33.cxDiabetes
,Chaptercx34.c x CardiovascularcxDisease
Chaptercx35.cxKidneycxDisease
Chaptercx36.c x PhysiologycxandcxDisorderscxofcxWater,cxElectrolyte,cxandcxAcid-BasecxMetabolism
Chaptercx37.cxcxLivercxDisease
Chaptercx38.c x GastrointestinalcxandcxPancreaticcxDiseases
Chaptercx39.cxcxDisorderscxofcxBonecxandcxMineralcxMetabolism
Chaptercx40.cxcxDisorderscxofcxthecxPituitarycxGland
Chaptercx41.c x DisorderscxofcxthecxAdrenalcxCortex
Chaptercx42.c x ThyroidcxDisorders
Chaptercx43.c x Reproduction-RelatedcxDisorders
Chaptercx44.cxcxPregnancycxandcxPrenatalcxTesting
Chaptercx45.c x NewborncxScreeningcxandcxInborncxErrorscxofcxMetabolism
Chaptercx46.cxPharmacogenetics
V.c x MolecularcxDiagnostics
Chaptercx47.cxPrinciplescxofcxMolecularcxBiology
Chaptercx48.cxNucleiccxAcidcxTechniquescxandcxApplications
Chaptercx49.cxGenomescxandcxNucleiccxAcidcxAlterations
, Chaptercx01:cxClinicalcxChemistry,cxMolecularcxDiagnostics,cxandcxLaboratorycxMedicinec
xTestcB
x ank
MULTIPLEcxCHOICE
1. Ancxindividualcxworkingcxincxacxclinicalcxchemistrycxlaboratorycxiscxmarriedcxtocxacxsalescxreprese
ntativecxwhocxworkscxforcxacxcompanycxthatcxsellscxchemistrycxlaboratorycxsupplies.cxWhencxthecxl
aboratorycxmanagercxrequestscxacxlistcxofcxneededcxsupplies,cxcostcxofcxsupplies,cxandcxvendors,cxth
iscxindividualcxonlycrx ecommendscxthecxspouse’scxcompanycxascxthecxvendor.cxThiscxiscxconsideredc
xtocxbecxa(n):
a. accountingcxissue.
b. possiblecxconflictcxofcxinterest.
c. maintenancecxofcxconfidentialitycxissue.
d. problemcxwithcxresourcecxallocation.
ANS:c x B
Concerncxhascxbeencxraisedcxovercxthecxinterrelationshipscxbetweencxpractitionerscxincxthecxmedica
lcxfieldcax ndcxcommercialcxsupplierscxofcxdrugs,cxdevices,cxequipment,cxetc.,cxtocxthecxmedicalcxprof
ession.
Similarly,cxrelationshipscxhavecxbeencxscrutinizedcxbetweencxclinicalcxlaboratorianscxandcxmanufa
cturerscxandcxproviderscxofcxdiagnosticcxequipmentcxandcxsupplies.cxThesecxconcernscxledcxthecxNat
ionalcxInstitutescxofcxHealthcx(NIH)cxincx1995cxtocxrequirecxofficialcxinstitutionalcxreviewcxofcxfinan
cialcxdisclosurecxbycxresearcherscxandcxmanagementcxofcxsituationscxincxwhichcxdisclosurecxindicate
scxpotentialcxconflictscxofcxinterest.
DIF: 1 REF:cxcxcxPagecx4-5 OBJ:c x 6cx|cx7
2. Acxpatientcxvisitscxhercxphysiciancxstatingcxthatcxhercxprescribedcxpainkillercxiscxnotcxworkingcxtoc
xreducecxthecxpaincxfollowingcxhercxrecentcxsurgery.cxAcxfriendcxofcxthecxpatientcxclaimscxthatcxthec
xsamecxpainkillercx“workedcxwonders”cxtocxreducecxhercxpaincxaftercxthecxsamecxsurgery.cxThecxph
ysiciancxstatescxthatcxthecxdifferencecxincxthecxeffectcxofcxthecxdrugcxmightcxbecxcausedcxby
,cxwhichcxiscxstudiedcxincxpharmacogenetics.
a. epidemiology
b. ancxinheritedcxdisease
c. acxconflictcxofcxinterest
d. acxgeneticcxvariationcxincxdrug-metabolizingcxenzymes
ANS:c x D
Pharmacogeneticscxiscxthecxstudycxofcxthecxgeneticcxvariationcxofcxdrugcxmetabolismcxbe
tweencixndividuals.
DIF: 1 REF:cxcxcxPagecx3 OBJ:c x 1
3. Johncxworkscxincxacxmolecularcxdiagnosticscxlaboratorycxandcxreceivescxacxbloodcxsamplecxthatcxh
ascxthecxnamecxofcxacxclosecxfriendcxprintedcxoncxthecxbar-
codedcxlabel.cxThecxgeneticcxtestcxthatcxiscxorderedcxoncxthecfx riend’scxsamplecxwouldcxprovidecxdi
agnosticcxinformationcxaboutcxacxdisordercxthatcxhascxacxpoorcxprognosis,cxandcxthecxtestcxiscxusua
llycxperformedcxbycxJohn.cxHecxaskscxacxfellowcxemployeecxtocxanalyzectxhecxsamplecxforcxhimcxan
dcxnotcxdivulgecxthecxresults.cxThiscxethicalcxissuecxconcerns:
a. confidentialitycxofcxpatientcxgeneticcxandcxmedicalcxinformation.
b. acxconflictcxofcxinterest.
c. resourcecxallocation.
d. diagnosticcxaccuracy.