TEST BANK
, Chapter 1: Principles of Pharmacology
Multiple Choice
1. refer(s) to specific molecular changes that occur when a drug binds to a
particular target site or receptor, while are the resulting widespread alterations in
function.
a. Drug action; therapeutic effects
b. Side effects; drug effects
c. Therapeutic effects; side effects
d. Drug action; drug effects
Answer: d
Textbook Reference: Pharmacology: The Science of Drug Action
2. After drug administration has occurred, the amount of drug in the blood that is free to
bind at specific target sites is referred to as a. the therapeutic dose.
b. first-pass effects.
c. bioavailability.
d. ED50. Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
3. The specific molecular changes that occur when a drug binds to a particular target
site or receptor are referred to as a. drug effects.
b. drug action.
c. side effects.
d. placebo effects.
Answer: b
Textbook Reference: Pharmacology: The Science of Drug Action
4. Which of the following is not a possible explanation for placebo effects?
a. Pavlovian conditioning
b. Genetic variation
c. Drug competition
d. Expectation of outcome
Answer: c
Textbook Reference: Pharmacology: The Science of Drug Action
, Page 1 of 247
5. The administration of oxytocin has been proposed as a treatment for autism. a.
intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
6. Which factor does not affect the pharmacokinetics of a drug?
a. Route of administration
b. Lipid solubility
c. Depot binding
d. Drug action
Answer: d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
7. First-pass metabolism occurs when drugs are taken
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
8. The area postrema is one area in the brain where the is not complete.
a. cerebrospinal fluid
b. blood–brain barrier
c. choroid plexus
d. phospholipid membrane
Answer: b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
9. First-pass metabolism occurs with orally administered drugs because
a. their absorption is slowed by food.
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way to general
circulation.
Page 2 of 247
, c. drugs must first survive the acidic environment of the stomach.
d. salivary enzymes in the mouth begin the process of metabolism.
Answer: b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
10. Toxic substances in the blood trigger a vomiting response by activating the
a. blood–brain barrier.
b. choroid plexus.
c. area postrema.
d. median eminence.
Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
11. Drugs radministered r_ r have rthe rmost rrapid ronset rof raction.
ra. rsubcutaneously r
b. intramuscularly r
c. orally r
d. intravenously r
Answer: rd r
Textbook rReference: rPharmacokinetic rFactors rDetermining rDrug rAction r
r
12. rIonization rof ra rdrug rdepends ron rthe r of rthe rsolution rand rthe r of rthe
rdrug. r
a. pH; rpKa r
b. pKa; rpH r
c. concentration; rlipid rsolubility r
d. pH; rconcentration r
Answer: ra r
Textbook rReference: rPharmacokinetic rFactors rDetermining rDrug rAction r
r
13. rThe rabsorption rof ra rdrug rdepends ron rall rof rthe rfollowing
rexcept ra. rlipid rsolubility. r
b. ionization. r
c. body rtemperature. r
d. the rconcentration rof rthe rdrug. r
Answer: rc r
Textbook rReference: rPharmacokinetic rFactors rDetermining rDrug rAction r
r
14. rDrugs rthat rare r should rbe ravoided rby rwomen rof rchildbearing
rage. ra. rteratogenic r
b. able rto rcross rthe rplacental rbarrier r
c. psychoactive r
d. highly rlipid-soluble r
Answer: ra r
Textbook rReference: rPharmacokinetic rFactors rDetermining rDrug rAction r
r
, Chapter 1: Principles of Pharmacology
Multiple Choice
1. refer(s) to specific molecular changes that occur when a drug binds to a
particular target site or receptor, while are the resulting widespread alterations in
function.
a. Drug action; therapeutic effects
b. Side effects; drug effects
c. Therapeutic effects; side effects
d. Drug action; drug effects
Answer: d
Textbook Reference: Pharmacology: The Science of Drug Action
2. After drug administration has occurred, the amount of drug in the blood that is free to
bind at specific target sites is referred to as a. the therapeutic dose.
b. first-pass effects.
c. bioavailability.
d. ED50. Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
3. The specific molecular changes that occur when a drug binds to a particular target
site or receptor are referred to as a. drug effects.
b. drug action.
c. side effects.
d. placebo effects.
Answer: b
Textbook Reference: Pharmacology: The Science of Drug Action
4. Which of the following is not a possible explanation for placebo effects?
a. Pavlovian conditioning
b. Genetic variation
c. Drug competition
d. Expectation of outcome
Answer: c
Textbook Reference: Pharmacology: The Science of Drug Action
, Page 1 of 247
5. The administration of oxytocin has been proposed as a treatment for autism. a.
intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
6. Which factor does not affect the pharmacokinetics of a drug?
a. Route of administration
b. Lipid solubility
c. Depot binding
d. Drug action
Answer: d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
7. First-pass metabolism occurs when drugs are taken
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
8. The area postrema is one area in the brain where the is not complete.
a. cerebrospinal fluid
b. blood–brain barrier
c. choroid plexus
d. phospholipid membrane
Answer: b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
9. First-pass metabolism occurs with orally administered drugs because
a. their absorption is slowed by food.
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way to general
circulation.
Page 2 of 247
, c. drugs must first survive the acidic environment of the stomach.
d. salivary enzymes in the mouth begin the process of metabolism.
Answer: b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
10. Toxic substances in the blood trigger a vomiting response by activating the
a. blood–brain barrier.
b. choroid plexus.
c. area postrema.
d. median eminence.
Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
11. Drugs radministered r_ r have rthe rmost rrapid ronset rof raction.
ra. rsubcutaneously r
b. intramuscularly r
c. orally r
d. intravenously r
Answer: rd r
Textbook rReference: rPharmacokinetic rFactors rDetermining rDrug rAction r
r
12. rIonization rof ra rdrug rdepends ron rthe r of rthe rsolution rand rthe r of rthe
rdrug. r
a. pH; rpKa r
b. pKa; rpH r
c. concentration; rlipid rsolubility r
d. pH; rconcentration r
Answer: ra r
Textbook rReference: rPharmacokinetic rFactors rDetermining rDrug rAction r
r
13. rThe rabsorption rof ra rdrug rdepends ron rall rof rthe rfollowing
rexcept ra. rlipid rsolubility. r
b. ionization. r
c. body rtemperature. r
d. the rconcentration rof rthe rdrug. r
Answer: rc r
Textbook rReference: rPharmacokinetic rFactors rDetermining rDrug rAction r
r
14. rDrugs rthat rare r should rbe ravoided rby rwomen rof rchildbearing
rage. ra. rteratogenic r
b. able rto rcross rthe rplacental rbarrier r
c. psychoactive r
d. highly rlipid-soluble r
Answer: ra r
Textbook rReference: rPharmacokinetic rFactors rDetermining rDrug rAction r
r
