EXAM 400 QUESTIONS AND CORRECT DETAILED
ANSWERS WITH RATIONALES (VERIFIED ANSWERS) |
ALREADY GRADED A+
volume of blood in adult - ANSWER: 4-6 L
pH of blood - ANSWER: 7.35-7.45
make up of whole blood - ANSWER: 55% plasma
45% erythrocytes
<1 % buffy coat
contains fibrinogen - ANSWER: plasma
RBC production 1-2 months fetal - ANSWER: yolk sac
RBC production 3-7 months fetal - ANSWER: liver and spleen
RBC production adults - ANSWER: bone marrow
At what stage of mitosis does the RBC leave the bone marrow? - ANSWER: G0: non
dividing
CFU-GEMM - ANSWER: colony forming unit (CFU) for myeloid cells
Do lymphatic stem cells self replicate? - ANSWER: no
rHuG-CSF - ANSWER: granulocyte stimulating factor, for AIDS patients
rHuEPO - ANSWER: increases RBC production, treatment of anemia
Erythropoietin - ANSWER: A hormone produced and released by the kidney that
stimulates the production of RBCs by the bone marrow.
Does RNA production in maturing RBCs increase or decrease? - ANSWER: decrease
Pronormoblast - ANSWER: Rubriblast
Basophilic normoblast - ANSWER: Prorubricyte
Polychromatophilic normoblast - ANSWER: Rubricyte
Orthochromic normoblast - ANSWER: Metarubricyte
, Polychromatophilic erythrocyte - ANSWER: reticulocyte
Polychromatophilic normoblast - ANSWER: clumping of nucleus
Necessary things for a RBC - ANSWER: normal membrane
Hgb
RBC metabolic pathways
Glycophorin - ANSWER: gives net - charge (zeta potential) to RBCs so they repel one
another
Spectrin - ANSWER: rod-like molecule to maintain integrity of RBC
What are RBCs easily permeable to? - ANSWER: H20, Cl-, HCO3-
What lipids are found on membrane of RBC? - ANSWER: cholesterol, choline
phospholipids, glycolipids, amino phospholipids
Form of iron used by heme - ANSWER: Ferrous
builds up with Pb poisoning - ANSWER: Delta-aminolevulinate
builds up with Pb poisoning - ANSWER: Coproporphyrinogen III
Transferin - ANSWER: transports Fe+3 to membrane of RBC precursors, inserts Fe+2
into protoporphyrin ring in mitochondria
Chromosome 16 - ANSWER: zeta, alpha
Chromosome 11 - ANSWER: epsilon, gamma, beta
Hgb Gower 1 - ANSWER: 2 zeta, 2 epsilon
Hgb Gower 2 - ANSWER: 2 alpha, 2 epsilon
Hgb Portland - ANSWER: 2 zeta, 2 gamma
Hgb A - ANSWER: 2 alpha, 2 beta
Hgb A1C - ANSWER: glycosylated hgb A
Hgb A2 - ANSWER: 2 alpha, 2 delta
Hgb F - ANSWER: 2 alpha, 2 gamma
alpha chains - ANSWER: 141 amino acids