RN HESI Pharmacology Exam V2 2025
2025/2026 Elite Study Resource | 100 Exam-Style Questions | Accuracy-Verified |
A+ Tier
EXAM OVERVIEW
This 2025/2026 validated resource contains the complete RN HESI Pharmacology
Exam V2 2025 with actual questions and verified answers. The examination measures
analytical reasoning, professional judgment, and practical application through 100
evidence-based scenarios that assess competency in contemporary professional
practice.
EXAM FEATURES
• 100 Evidence-Based Multiple Choice Questions
• Comprehensive Answer Keys with Clinical Rationales
• Critical Analysis and Applied Reasoning Emphasis
• Current 2025 Evidence-Based Practice Standards Integration
• 8 Professional Domains Comprehensively Assessed
• Real-World Application Scenarios with Professional Context
CORE TESTING AREAS
→ Medication Administration & Safety
→ Pharmacokinetics & Pharmacodynamics
→ Autonomic & Cardiovascular Medications
→ Central Nervous System Medications
→ Anti-infective Agents
→ Endocrine Medications
→ Respiratory Medications
→ Gastrointestinal Medications
Page 1
,Question 1
A 58-year-old man has been taking atenolol for two years to control hypertension. His
provider recently switched him to enalapril. He calls the clinic asking how to take the new
medication safely. Which instruction should the nurse prioritize when teaching this client
about enalapril?
A. Take the medication with food to reduce gastrointestinal upset.
B. Monitor blood pressure daily and report any episodes of dizziness or lightheadedness.
C. Discontinue the medication immediately if a dry cough develops without contacting the
provider.
D. Take the dose at bedtime to avoid nocturnal hypotension.
Correct Answer
Monitor blood pressure daily and report any episodes of dizziness or lightheadedness.
Rationale:
Enalapril can cause hypotension; patients should monitor BP and report dizziness, indicating possible
excessive lowering.
Question 2
A 32-year-old female client completed a 5‑day course of amoxicillin for a sinus infection.
She now reports vaginal itching, burning, and a thick white discharge. Which action should
the nurse discuss with the client regarding these new symptoms?
A. Begin an over‑the‑counter fluconazole regimen immediately.
B. Increase fluid intake and monitor for improvement.
C. Contact the health‑care provider because the symptoms suggest a possible yeast
infection requiring prescription treatment.
D. Continue the antibiotic; the symptoms will resolve on their own.
Correct Answer
Contact the health‑care provider because the symptoms suggest a possible yeast
infection requiring prescription treatment.
Rationale:
Antibiotic‑associated candidiasis requires evaluation and possibly prescription antifungal therapy.
Page 2
,Question 3
During a routine round, a 24-year-old client with a history of asthma develops wheezing,
shortness of breath, and a tight chest. The nurse administers a PRN short‑acting
β2‑agonist inhaler. Which of the following client responses is most expected after the
medication is given?
A. A noticeable decrease in heart rate.
B. Mild tremor and a slight increase in heart rate.
C. A significant rise in blood pressure.
D. Worsening bronchoconstriction.
Correct Answer
Mild tremor and a slight increase in heart rate.
Rationale:
β2‑agonists commonly cause peripheral tremor and transient tachycardia due to β2 receptor stimulation.
Question 4
A 66-year-old client on atenolol for hypertension presents with a blood pressure of 120/68
mmHg, a sinus bradycardia of 58 beats/min, and a PR interval of 0.24 seconds on ECG.
What is the most appropriate nursing action?
A. Hold the next dose of atenolol and notify the health‑care provider.
B. Increase the atenolol dose to achieve a lower heart rate.
C. Encourage the client to rise slowly from a seated position.
D. Document the findings and continue the medication as prescribed.
Correct Answer
Hold the next dose of atenolol and notify the health‑care provider.
Rationale:
Bradycardia with a prolonged PR interval suggests excessive β‑blockade; the dose should be held and the
provider notified.
Page 3
, Question 5
A 45-year-old woman has been prescribed lisinopril 10 mg daily for hypertension. She asks
when she can expect the medication's peak antihypertensive effect after a dose.
Approximately how long after administration does lisinopril reach peak effect?
A. Within 30 minutes.
B. Within 1 to 2 hours.
C. Within 4 to 6 hours.
D. Around 12 hours.
Correct Answer
Within 1 to 2 hours.
Rationale:
Lisinopril, an ACE inhibitor, typically reaches peak plasma concentration and effect within 1-2 hours after oral
dosing.
Question 6
A 47-year-old man is admitted for postoperative care after an appendectomy. He is
prescribed subcutaneous regular insulin sliding scale before meals. Before administering
the first dose, the nurse reviews the medication order, checks the patient's identification
band, and confirms the insulin type. Which of the following actions completes the "rights"
of medication administration for this insulin dose?
A. Verify the dose calculation based on blood glucose
B. Administer the insulin in the medication room
C. Document the administration after giving the dose
D. Ask the patient to self‑administer
Correct Answer
Verify the dose calculation based on blood glucose
Rationale:
Ensuring the correct dose is administered fulfills the right dose component of safe medication administration.
Page 4
2025/2026 Elite Study Resource | 100 Exam-Style Questions | Accuracy-Verified |
A+ Tier
EXAM OVERVIEW
This 2025/2026 validated resource contains the complete RN HESI Pharmacology
Exam V2 2025 with actual questions and verified answers. The examination measures
analytical reasoning, professional judgment, and practical application through 100
evidence-based scenarios that assess competency in contemporary professional
practice.
EXAM FEATURES
• 100 Evidence-Based Multiple Choice Questions
• Comprehensive Answer Keys with Clinical Rationales
• Critical Analysis and Applied Reasoning Emphasis
• Current 2025 Evidence-Based Practice Standards Integration
• 8 Professional Domains Comprehensively Assessed
• Real-World Application Scenarios with Professional Context
CORE TESTING AREAS
→ Medication Administration & Safety
→ Pharmacokinetics & Pharmacodynamics
→ Autonomic & Cardiovascular Medications
→ Central Nervous System Medications
→ Anti-infective Agents
→ Endocrine Medications
→ Respiratory Medications
→ Gastrointestinal Medications
Page 1
,Question 1
A 58-year-old man has been taking atenolol for two years to control hypertension. His
provider recently switched him to enalapril. He calls the clinic asking how to take the new
medication safely. Which instruction should the nurse prioritize when teaching this client
about enalapril?
A. Take the medication with food to reduce gastrointestinal upset.
B. Monitor blood pressure daily and report any episodes of dizziness or lightheadedness.
C. Discontinue the medication immediately if a dry cough develops without contacting the
provider.
D. Take the dose at bedtime to avoid nocturnal hypotension.
Correct Answer
Monitor blood pressure daily and report any episodes of dizziness or lightheadedness.
Rationale:
Enalapril can cause hypotension; patients should monitor BP and report dizziness, indicating possible
excessive lowering.
Question 2
A 32-year-old female client completed a 5‑day course of amoxicillin for a sinus infection.
She now reports vaginal itching, burning, and a thick white discharge. Which action should
the nurse discuss with the client regarding these new symptoms?
A. Begin an over‑the‑counter fluconazole regimen immediately.
B. Increase fluid intake and monitor for improvement.
C. Contact the health‑care provider because the symptoms suggest a possible yeast
infection requiring prescription treatment.
D. Continue the antibiotic; the symptoms will resolve on their own.
Correct Answer
Contact the health‑care provider because the symptoms suggest a possible yeast
infection requiring prescription treatment.
Rationale:
Antibiotic‑associated candidiasis requires evaluation and possibly prescription antifungal therapy.
Page 2
,Question 3
During a routine round, a 24-year-old client with a history of asthma develops wheezing,
shortness of breath, and a tight chest. The nurse administers a PRN short‑acting
β2‑agonist inhaler. Which of the following client responses is most expected after the
medication is given?
A. A noticeable decrease in heart rate.
B. Mild tremor and a slight increase in heart rate.
C. A significant rise in blood pressure.
D. Worsening bronchoconstriction.
Correct Answer
Mild tremor and a slight increase in heart rate.
Rationale:
β2‑agonists commonly cause peripheral tremor and transient tachycardia due to β2 receptor stimulation.
Question 4
A 66-year-old client on atenolol for hypertension presents with a blood pressure of 120/68
mmHg, a sinus bradycardia of 58 beats/min, and a PR interval of 0.24 seconds on ECG.
What is the most appropriate nursing action?
A. Hold the next dose of atenolol and notify the health‑care provider.
B. Increase the atenolol dose to achieve a lower heart rate.
C. Encourage the client to rise slowly from a seated position.
D. Document the findings and continue the medication as prescribed.
Correct Answer
Hold the next dose of atenolol and notify the health‑care provider.
Rationale:
Bradycardia with a prolonged PR interval suggests excessive β‑blockade; the dose should be held and the
provider notified.
Page 3
, Question 5
A 45-year-old woman has been prescribed lisinopril 10 mg daily for hypertension. She asks
when she can expect the medication's peak antihypertensive effect after a dose.
Approximately how long after administration does lisinopril reach peak effect?
A. Within 30 minutes.
B. Within 1 to 2 hours.
C. Within 4 to 6 hours.
D. Around 12 hours.
Correct Answer
Within 1 to 2 hours.
Rationale:
Lisinopril, an ACE inhibitor, typically reaches peak plasma concentration and effect within 1-2 hours after oral
dosing.
Question 6
A 47-year-old man is admitted for postoperative care after an appendectomy. He is
prescribed subcutaneous regular insulin sliding scale before meals. Before administering
the first dose, the nurse reviews the medication order, checks the patient's identification
band, and confirms the insulin type. Which of the following actions completes the "rights"
of medication administration for this insulin dose?
A. Verify the dose calculation based on blood glucose
B. Administer the insulin in the medication room
C. Document the administration after giving the dose
D. Ask the patient to self‑administer
Correct Answer
Verify the dose calculation based on blood glucose
Rationale:
Ensuring the correct dose is administered fulfills the right dose component of safe medication administration.
Page 4
