Applied Pathophysiology For The Advanced Practice Nurse
2nd Edition 2nd Lucie Dlugasch All Chapters Available
,
,
,World Headquarters
Jones & Bartlett Learning
25 Mall Road
Burlington, MA 01803
978-443-5000
www.jblearning.com
Jones & Bartlett Learning books and products are available through most bookstores and online
booksellers. To contact Jones & Bartlett Learning directly, call 800-832-0034, fax 978-443-8000,
or visit our website, www.jblearning.com.
Substantial discounts on bulk quantities of Jones & Bartlett Learning publications are available
to corporations, professional associations, and other qualified organizations. For details and
specific discount information, contact the special sales department at Jones & Bartlett Learning
via the above contact information or send an email to .
Copyright © 2024 by Jones & Bartlett Learning, LLC, an Ascend Learning Company
All rights reserved. No part of the material protected by this copyright may be reproduced or
utilized in any form, electronic or mechanical, including photocopying, recording, or by any
information storage and retrieval system, without written permission from the copyright owner.
The content, statements, views, and opinions herein are the sole expression of the respective
authors and not that of Jones & Bartlett Learning, LLC. Reference herein to any specific
commercial product, process, or service by trade name, trademark, manufacturer, or otherwise
does not constitute or imply its endorsement or recommendation by Jones & Bartlett Learning,
LLC and such reference shall not be used for advertising or product endorsement purposes. All
trademarks displayed are the trademarks of the parties noted herein. Applied Pathophysiology for
the Advanced Practice Nurse, Second Edition is an independent publication and has not been
authorized, sponsored, or otherwise approved by the owners of the trademarks or service marks
referenced in this product.
There may be images in this book that feature models; these models do not necessarily endorse,
represent, or participate in the activities represented in the images. Any screenshots in this
product are for educational and instructive purposes only. Any individuals and scenarios featured
in the case studies throughout this product may be real or fictitious but are used for instructional
purposes only.
The authors, editor, and publisher have made every effort to provide accurate information.
However, they are not responsible for errors, omissions, or for any outcomes related to the use of
the contents of this book and take no responsibility for the use of the products and procedures
described. Treatments and side effects described in this book may not be applicable to all people;
likewise, some people may require a dose or experience a side effect that is not described herein.
Drugs and medical devices are discussed that may have limited availability controlled by the Food
and Drug Administration (FDA) for use only in a research study or clinical trial. Research, clinical
,practice, and government regulations often change the accepted standard in this field. When
consideration is being given to use of any drug in the clinical setting, the healthcare provider or
reader is responsible for determining FDA status of the drug, reading the package insert, and
reviewing prescribing information for the most up-to-date recommendations on dose, precautions,
and contraindications, and determining the appropriate usage for the product. This is especially
important in the case of drugs that are new or seldom used.
25568-3
Production Credits
Vice President, Product Management: Marisa R. Urbano
Vice President, Content Strategy and Implementation: Christine Emerton
Director, Product Management: Matthew Kane
Product Manager: Tina Chen
Director, Content Management: Donna Gridley
Content Coordinator: Samantha Gillespie
Director, Project Management and Content Services: Karen Scott
Manager, Project Management: Jackie Reynen
Project Manager: Roberta Sherman
Senior Product Marketing Manager: Lindsay White
Content Services Manager: Colleen Lamy
Product Fulfillment Manager: Wendy Kilborn
Composition: S4Carlisle Publishing Services
Cover Design: Michael O’Donnell
Senior Media Development Editor: Troy Liston
Rights & Permissions Manager: John Rusk
Rights Specialist: Maria Leon Maimone
Cover and Title Page Image: © Cavan Images/Getty Images
Printing and Binding: Lakeside Book Company
Library of Congress Cataloging-in-Publication Data
Names: Dlugasch, Lucie, author. | Story, Lachel, author.
Title: Applied pathophysiology for the advanced practice nurse / Lucie Dlugasch, Lachel Story.
Description: Second edition. | Burlington, Massachusetts : Jones & Bartlett Learning, [2024] |
Includes bibliographical references and index.
Identifiers: LCCN 2022032187 | ISBN 9781284255614 (paperback)
Subjects: MESH: Pathology | Physiology | Advanced Practice Nursing | Nurses Instruction
Classification: LCC RB113 | NLM QZ 140 | DDC 616.07--dc23/eng/20221209
LC record available at https://lccn.loc.gov/2022032187
6048
Printed in the United States of America
27 26 25 24 23 10 9 8 7 6 5 4 3 2 1
, © Cavan Images/Getty Images.
Brief Contents
Preface
New to this Edition
Contributors
Acknowledgments
CHAPTER 1 Cellular Function
CHAPTER 2 Immunity
CHAPTER 3 Hematopoietic Function
CHAPTER 4 Cardiovascular Function
CHAPTER 5 Pulmonary Function
CHAPTER 6 Fluid, Electrolyte, and Acid–Base Homeostasis
CHAPTER 7 Urinary Function
CHAPTER 8 Reproductive Function
CHAPTER 9 Gastrointestinal Function
CHAPTER 10 Endocrine Function
CHAPTER 11 Neural Function
,CHAPTER 12 Musculoskeletal Function
CHAPTER 13 Integumentary Function
CHAPTER 14 Sensory Function
Glossary
Index
, © Cavan Images/Getty Images.
Diagnostic Links
CHAPTER 1
Osmolality, Osmolarity, and Osmolar Gap
Lactate Levels
Nucleic Acid Amplification Testing (NAAT) and Polymerase Chain
Reaction (PCR)
Methods of Genetic Testing
CHAPTER 2
Acute Phase Reactants
IgG and IgM
Sample Collection for Infection
Evaluating Microorganisms
Specificity and Sensitivity
CHAPTER 4
Echocardiogram
Computed Tomography for Coronary Artery Calcium Scoring
Homocysteine
Point-of-Care Ultrasonography
CHAPTER 5
Pulse Oximetry
End-Tidal Carbon Dioxide Monitoring
,Monospot
Chest X-Ray: Consolidation
Lung Cancer Screening with Computed Tomography Scanning
CHAPTER 6
Urine: Specific Gravity and Urine Osmolality
Pseudohyperkalemia
Vitamin D
Calcium and Albumin Levels
Blood Gases: Arterial and Venous
CHAPTER 7
Estimating GFR
Blood Urea Nitrogen and Serum Creatinine
Urinalysis Components
Urinary Casts
Urine Culture and Sensitivity
Urinary Imaging
Cystoscopy and Ureteroscopy
Hematuria
Prostate-Specific Antigen
Proteinuria vs. Albuminuria
CHAPTER 8
Laboratory Evaluation of Hypogonadism
CHAPTER 9
Liver Injury
Bilirubin Measurement
Liver Function
CHAPTER 10
Serum Hormone Levels
CHAPTER 14
Fluorescein Staining
, © Cavan Images/Getty Images.
Contents
Preface
New to this Edition
Contributors
Acknowledgments
CHAPTER 1 Cellular Function
Basic Cell Function and Structure
Cellular Components
Exchanging Material
Energy Production
Chromosomes, DNA, and Genes
Replication and Differentiation
Cellular Organization
Types of Tissue
Cellular Adaptation and Damage
Cellular Adaptation
Cellular Injury and Death
Genetic and Epigenetic Alterations
Benign and Malignant Neoplasms
Genetic and Congenital Disorders
Patterns of Inheritance
Single-Gene Disorders
Chromosomal Disorders—Number or Structural
Autosomal Aneuploidy
X-Linked Aneuploidy
2nd Edition 2nd Lucie Dlugasch All Chapters Available
,
,
,World Headquarters
Jones & Bartlett Learning
25 Mall Road
Burlington, MA 01803
978-443-5000
www.jblearning.com
Jones & Bartlett Learning books and products are available through most bookstores and online
booksellers. To contact Jones & Bartlett Learning directly, call 800-832-0034, fax 978-443-8000,
or visit our website, www.jblearning.com.
Substantial discounts on bulk quantities of Jones & Bartlett Learning publications are available
to corporations, professional associations, and other qualified organizations. For details and
specific discount information, contact the special sales department at Jones & Bartlett Learning
via the above contact information or send an email to .
Copyright © 2024 by Jones & Bartlett Learning, LLC, an Ascend Learning Company
All rights reserved. No part of the material protected by this copyright may be reproduced or
utilized in any form, electronic or mechanical, including photocopying, recording, or by any
information storage and retrieval system, without written permission from the copyright owner.
The content, statements, views, and opinions herein are the sole expression of the respective
authors and not that of Jones & Bartlett Learning, LLC. Reference herein to any specific
commercial product, process, or service by trade name, trademark, manufacturer, or otherwise
does not constitute or imply its endorsement or recommendation by Jones & Bartlett Learning,
LLC and such reference shall not be used for advertising or product endorsement purposes. All
trademarks displayed are the trademarks of the parties noted herein. Applied Pathophysiology for
the Advanced Practice Nurse, Second Edition is an independent publication and has not been
authorized, sponsored, or otherwise approved by the owners of the trademarks or service marks
referenced in this product.
There may be images in this book that feature models; these models do not necessarily endorse,
represent, or participate in the activities represented in the images. Any screenshots in this
product are for educational and instructive purposes only. Any individuals and scenarios featured
in the case studies throughout this product may be real or fictitious but are used for instructional
purposes only.
The authors, editor, and publisher have made every effort to provide accurate information.
However, they are not responsible for errors, omissions, or for any outcomes related to the use of
the contents of this book and take no responsibility for the use of the products and procedures
described. Treatments and side effects described in this book may not be applicable to all people;
likewise, some people may require a dose or experience a side effect that is not described herein.
Drugs and medical devices are discussed that may have limited availability controlled by the Food
and Drug Administration (FDA) for use only in a research study or clinical trial. Research, clinical
,practice, and government regulations often change the accepted standard in this field. When
consideration is being given to use of any drug in the clinical setting, the healthcare provider or
reader is responsible for determining FDA status of the drug, reading the package insert, and
reviewing prescribing information for the most up-to-date recommendations on dose, precautions,
and contraindications, and determining the appropriate usage for the product. This is especially
important in the case of drugs that are new or seldom used.
25568-3
Production Credits
Vice President, Product Management: Marisa R. Urbano
Vice President, Content Strategy and Implementation: Christine Emerton
Director, Product Management: Matthew Kane
Product Manager: Tina Chen
Director, Content Management: Donna Gridley
Content Coordinator: Samantha Gillespie
Director, Project Management and Content Services: Karen Scott
Manager, Project Management: Jackie Reynen
Project Manager: Roberta Sherman
Senior Product Marketing Manager: Lindsay White
Content Services Manager: Colleen Lamy
Product Fulfillment Manager: Wendy Kilborn
Composition: S4Carlisle Publishing Services
Cover Design: Michael O’Donnell
Senior Media Development Editor: Troy Liston
Rights & Permissions Manager: John Rusk
Rights Specialist: Maria Leon Maimone
Cover and Title Page Image: © Cavan Images/Getty Images
Printing and Binding: Lakeside Book Company
Library of Congress Cataloging-in-Publication Data
Names: Dlugasch, Lucie, author. | Story, Lachel, author.
Title: Applied pathophysiology for the advanced practice nurse / Lucie Dlugasch, Lachel Story.
Description: Second edition. | Burlington, Massachusetts : Jones & Bartlett Learning, [2024] |
Includes bibliographical references and index.
Identifiers: LCCN 2022032187 | ISBN 9781284255614 (paperback)
Subjects: MESH: Pathology | Physiology | Advanced Practice Nursing | Nurses Instruction
Classification: LCC RB113 | NLM QZ 140 | DDC 616.07--dc23/eng/20221209
LC record available at https://lccn.loc.gov/2022032187
6048
Printed in the United States of America
27 26 25 24 23 10 9 8 7 6 5 4 3 2 1
, © Cavan Images/Getty Images.
Brief Contents
Preface
New to this Edition
Contributors
Acknowledgments
CHAPTER 1 Cellular Function
CHAPTER 2 Immunity
CHAPTER 3 Hematopoietic Function
CHAPTER 4 Cardiovascular Function
CHAPTER 5 Pulmonary Function
CHAPTER 6 Fluid, Electrolyte, and Acid–Base Homeostasis
CHAPTER 7 Urinary Function
CHAPTER 8 Reproductive Function
CHAPTER 9 Gastrointestinal Function
CHAPTER 10 Endocrine Function
CHAPTER 11 Neural Function
,CHAPTER 12 Musculoskeletal Function
CHAPTER 13 Integumentary Function
CHAPTER 14 Sensory Function
Glossary
Index
, © Cavan Images/Getty Images.
Diagnostic Links
CHAPTER 1
Osmolality, Osmolarity, and Osmolar Gap
Lactate Levels
Nucleic Acid Amplification Testing (NAAT) and Polymerase Chain
Reaction (PCR)
Methods of Genetic Testing
CHAPTER 2
Acute Phase Reactants
IgG and IgM
Sample Collection for Infection
Evaluating Microorganisms
Specificity and Sensitivity
CHAPTER 4
Echocardiogram
Computed Tomography for Coronary Artery Calcium Scoring
Homocysteine
Point-of-Care Ultrasonography
CHAPTER 5
Pulse Oximetry
End-Tidal Carbon Dioxide Monitoring
,Monospot
Chest X-Ray: Consolidation
Lung Cancer Screening with Computed Tomography Scanning
CHAPTER 6
Urine: Specific Gravity and Urine Osmolality
Pseudohyperkalemia
Vitamin D
Calcium and Albumin Levels
Blood Gases: Arterial and Venous
CHAPTER 7
Estimating GFR
Blood Urea Nitrogen and Serum Creatinine
Urinalysis Components
Urinary Casts
Urine Culture and Sensitivity
Urinary Imaging
Cystoscopy and Ureteroscopy
Hematuria
Prostate-Specific Antigen
Proteinuria vs. Albuminuria
CHAPTER 8
Laboratory Evaluation of Hypogonadism
CHAPTER 9
Liver Injury
Bilirubin Measurement
Liver Function
CHAPTER 10
Serum Hormone Levels
CHAPTER 14
Fluorescein Staining
, © Cavan Images/Getty Images.
Contents
Preface
New to this Edition
Contributors
Acknowledgments
CHAPTER 1 Cellular Function
Basic Cell Function and Structure
Cellular Components
Exchanging Material
Energy Production
Chromosomes, DNA, and Genes
Replication and Differentiation
Cellular Organization
Types of Tissue
Cellular Adaptation and Damage
Cellular Adaptation
Cellular Injury and Death
Genetic and Epigenetic Alterations
Benign and Malignant Neoplasms
Genetic and Congenital Disorders
Patterns of Inheritance
Single-Gene Disorders
Chromosomal Disorders—Number or Structural
Autosomal Aneuploidy
X-Linked Aneuploidy
