2025 Questions and Answers 100% Pass
Cancer - ✔✔Leading cause of death worldwide
Cancer treatment modalities - ✔✔Surgery, radiation, chemotherapy
Chemotherapy - ✔✔Not highly efficient in killing tumor cells
Pharmacokinetics - ✔✔Study of drug movement within the body
Chemotherapy drugs - ✔✔Poor pharmacokinetics and systemic toxicities
Advantages of nanomedicine - ✔✔Longer circulation time, reduced side effects,
controlled and sustained drug release
EPR effect - ✔✔Enhanced permeability and retention in tumors
Liposome - ✔✔Composed of a phospholipid bilayer
Liposome encapsulation - ✔✔Can encapsulate both hydrophobic and hydrophilic drugs
Polymeric micelle - ✔✔Made up of biosurfactant with hydrophobic tail
Currently approved nanocarriers - ✔✔Use biologically functional materials
Polyethylene glycol (PEG) - ✔✔Not hydrophobic
PEGylation - ✔✔Increases drug size, improves solubility, avoids recognition/binding of
mononuclear phagocyte system
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